Human Experience In clinical trials and in postmarketing experience, adverse reactions of deliberate or accidental overdosage with oral Abilify have been reported worldwide. These include overdoses with oral Abilify alone and in combination with other substances. No fatality was reported with Abilify alone. Other clinically important signs and symptoms observed in one or more patients with Abilify overdoses alone or with other substances include acidosis, aggression, aspartate aminotransferase increased, atrial fibrillation, bradycardia, coma, confusional state, convulsion, blood creatine phosphokinase increased, depressed level of consciousness, hypertension, hypokalemia, hypotension, lethargy, loss of consciousness, QRS complex prolonged, QT prolonged, pneumonia aspiration, respiratory arrest, status epilepticus, and tachycardia.

Management of Overdosage No specific information is available on the treatment of overdose with Abilify. An electrocardiogram should be obtained in case of overdosage and if QT interval prolongation is present, cardiac monitoring should be instituted.

Otherwise, management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms. Close medical supervision and monitoring should continue until the patient recovers. In the event of an overdose of Abilify, an early charcoal administration may be useful in partially preventing the absorption of aripiprazole.

Although there is no information on the effect of hemodialysis in treating an overdose with Abilify, hemodialysis is unlikely to be useful in overdose management since aripiprazole is highly bound to plasma proteins. Aripiprazole is 7-[4-[4- 2,3-dichlorophenyl piperazinyl]butoxy]-3,4-dihydrocarbostyril. The chemical structure is: Inactive ingredients include cornstarch, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. The inactive ingredients for this solution include disodium edetate, fructose, glycerin, dl-lactic acid, methylparaben, propylene glycol, propylparaben, sodium hydroxide, sucrose, and purified water.

The oral solution is flavored with natural orange cream and other natural flavors. Abilify Injection is available in single-dose vials as a ready-to-use, 9.

Inactive ingredients for this solution include Abilify - Clinical Pharmacology Mechanism of Action The mechanism of action of aripiprazole in schizophrenia or bipolar mania, is unknown. However, the efficacy of aripiprazole could be mediated through a combination of partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors. The mean elimination half-lives are about 75 hours and 94 hours for aripiprazole and dehydro-aripiprazole, respectively.

Steady-state concentrations are attained within 14 days of dosing for both active moieties. Aripiprazole accumulation is predictable from single-dose pharmacokinetics.

At steady-state, the pharmacokinetics of aripiprazole is dose-proportional. For CYP2D6 poor metabolizers, the mean elimination half-life for aripiprazole is about hours. Abilify can be administered with or without food. Aripiprazole is well absorbed when administered orally as the solution. At equivalent doses, the plasma concentrations of aripiprazole from the solution were higher than that from the tablet formulation.

Distribution The steady-state volume of distribution of aripiprazole following intravenous administration is high L or 4. In healthy human volunteers administered 0. Metabolism and Elimination Aripiprazole is metabolized primarily by three biotransformation pathways: Aripiprazole is the predominant drug moiety in the systemic circulation.

Drug Interaction Studies Effects of other drugs on the exposures of aripiprazole and dehydro-aripiprazole are summarized in Figure 1 and Figure 2, respectively. Based on simulation, a 4. The effects of other drugs on aripiprazole pharmacokinetics Figure 2: To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

The manufacturer directs to swallow this medication whole. Follow your doctor's direction on how to take this medication.

Do not use a household spoon because you may not get the correct dose. Do not increase your dose or use this drug more often or for longer than prescribed.

Your condition will not improve any faster, and your risk of side effects will increase. It may take several weeks before you get the full benefit of this drug. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor.

Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased. Tell your doctor if your condition does not improve or if it worsens. Side Effects See also Warning section. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Dizziness and lightheadedness can increase the risk of falling. Get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: This medication may rarely make your blood sugar rise, which can cause or worsen diabetes.

If you already have diabetes , check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program , or diet.

This medication may rarely cause a condition called tardive dyskinesia. In some cases, this condition may be permanent. Tell your doctor right away if you develop any unusual uncontrolled movements especially of the face, mouth , tongue , arms, or legs. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome NMS. Get medical help right away if you have any of the following symptoms: A very serious allergic reaction to this drug is rare.

However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects. Food and Drug Administration by visiting www. Jennifer Carey, PharmD Q: What are the side effects of Abilify, particularly long term? Is tardive dyskinesia prominent? What are the effects of Geodon, particularly long term? The long-term effects of using Abilify have not effectively been quantified; one reason is that many patients are taking more than one medication for their symptoms.

Secondly, this medication has not been used sufficiently long enough to collect enough data in this area. I did find one study that revealed tardive dyskinesia with the use of Abilify.

However, due to the specificity of Abilify, it is my understanding that it is one of the safer medications out currently, given its scope of treatment. As you can see by reading the article, after being switched to Seroquel quetiapine the symptoms of the TD disappeared. What over-the-counter cold medications can someone take who is also taking Abilify? There are many over-the-counter OTC cold medicines, and they often contain several active ingredients to combat cold symptoms.

The following is a list of common active ingredients in cold remedies. OTC decongestants include phenylephrine and pseudoephedrine. In some states, you may need to ask the pharmacist for pseudoephedrine, but you do not need a prescription from your doctor. These drugs work to reduce swelling in your nose by constricting blood vessels, making it is easier for you to breath.

The common side effects of these medications are nervousness, dizziness, and an inability to sleep; heart palpitations and high blood pressure are also possible. These drugs are generally used during the day, but they can make some people feel jittery and restless. Antihistamines are commonly used in cold remedies because they work to prevent part of the allergic response that causes itching, sneezing, runny nose, and watery eyes.

There are two types of antihistamines. First-generation older antihistamines include brompheniramine, chlorpheniramine, dimenhydrinate, diphenhydramine, and doxylamine. These drugs can make you feel sleepy and make it difficult for you to think clearly.

They can also cause dry mouth and abdominal pain. Second-generation newer antihistamines include loratadine and cetirizine, and they are much less likely to cause side effects, including drowsiness. Cough medicines include dextromethorphan, a cough suppressant that works to block the cough reflex, and guaifenesin, an expectorant that thins mucous to help you cough it up and out of your airway. Side effects are uncommon with these medicines in healthy individuals.

Lastly, pain relievers, such as aspirin, acetaminophen, and ibuprofen, are used to relieve headache and reduce fever. When taken occasionally for pain or fever, side effects are rare.

Ibuprofen can irritate your stomach, so it should be taken with food. A review of package inserts and medical literature showed that antihistamines have the potential to interact with Abilify aripiprazole. Antihistamines have anti-cholinergic activity and this activity can increase the risk of some side effects of drugs like Abilify.

The combination of an antihistamine and Abilify can cause the following: It is recommended that patients who use these medications in combination avoid activities requiring mental alertness until they know how these agents affect them. There is no information to suggest an interaction occurs between Abilify and decongestants, cough medicines, aspirin, acetaminophen, or ibuprofen. If you are concerned about using cold medicine with your prescription Abilify, please contact your healthcare provider.

For help picking an appropriate cold medicine, speak with your local pharmacist. Abilify is indicated for schizophrenia and bipolar disorder. Abilify also can be used for mood disorder such as mood swings, temper tantrums and aggression. Side effects of Abilify include dizziness, drowsiness, headache, and weight gain. Other side effects reported with Abilify include musculoskeletal stiffness and muscle spasms. Drugs can cause weight gain in several different ways.

Some can increase appetite or make you crave certain types of foods like those high in carbohydrates or fat. Other medications may slow down metabolism or cause fluid retention. However, the effect of prescription drugs on body weight is complex. Some drugs have no effect on weight, while others cause weight gain or weight loss. Also, the same medications can cause weight gain in certain individuals and weight loss in others.

There are also drugs that initially cause weight loss and then lead to weight gain with long-term use. Most prescription medications associated with changes in body weight affect the central nervous system. Mood stabilizers lithium, valproic acid , antipsychotics, and anticonvulsants have also been linked with weight gain. Other drugs that have been reported to cause weight gain include diabetes medications insulin, sulfonylureas, and thiazolidinediones , antihypertensive drugs, certain hormonal contraceptives, corticosteroids, antihistamines, some chemotherapy regimens, and antiretroviral protease inhibitors.

If you think a drug you are taking is causing weight gain, tell your health care provider. Do not stop any medication or change the dose without first talking to your provider. Kimberly Hotz, PharmD Q: Does coming off Abilify have any side effects? Abilify aripiprazole is a medication that is used to treat various mental conditions, including bipolar disorder, depression, and schizophrenia. It is not recommended that you stop Abilify without your health care provider's approval.

Although Abilify is not addicting, the brain may need time to adjust after you stop taking Abilify. According to the prescribing information on Abilify, withdrawal symptoms can include: These side effects may not decrease over time due to the fact that they are symptoms of the underlying condition. Your health care provider may decide to wean you off Abilify slowly to avoid severe withdrawal symptoms.

Even if you are switching to another medication, your health care provider may still recommend stopping Abilify slowly. You should consult with your physician before stopping Abilify and let him or her know any side effects you may be experiencing while stopping the medication. Is there a generic substitute for Abilify? Or something else I could take for depression as a result of bipolar disorder? I take lithium for mania, which works well.

I stopped Lamictal because it gave me a severe rash. Brand-name prescription drugs are protected under patent. When the patent expires, other drug companies can start manufacturing and selling a generic form of the drug. The patent for Abilify aripiprazole won't expire until , so no generic form is currently available. Other medications are available to help manage bipolar disorder, but the choice of medication will depend on your individual circumstances.

Consult your physician or health care provider for recommendations specific to your situation. Sarah Lewis, PharmD Q: I have been taking Abilify for about three years and am still gaining weight. I get a lot of questions regarding people gaining weight on Abilify aripiprazole.

There are some physicians that have recommended that patients start taking Glucophage metformin in addition to this medication to help control the weight gain and in some cases reduce it. Some other lifestyle changes such as these may be helpful: Get to bed earlier at night, cut soda out of your diet for good, have fiber with every meal, go for a short walk after each meal, get at least 15 to 20 minutes of sunlight every day, learn to meditate, even if it's only for five minutes a day, drink a cup of green tea daily if okay with prescriber , start supplementation of omega-3 fatty acids, watch sodium content in foods because a decrease in sodium will decrease water retention.

What are the side effects of Abilify? Abilify aripiprazole is an antipsychotic medication which affects chemicals in the brain. Abilify is used for managing the symptoms of bipolar disorder, schizophrenia, and major depression in combination with antidepressants. Abilify is also used to treat symptoms of autism, such as irritability, aggression, mood swings, temper tantrums, and self-injury.

Common side effects of Abilify include weight gain, constipation, nausea, vomiting, dizziness, weakness, drowsiness, tiredness, headache, tremor, insomnia, blurred vision, and anxiety.

More serious side effects are possible. Contact your doctor right away if you experience any muscle difficulties, stiff muscles, jerky movements, uncontrollable movements, weakness, difficulty talking or swallowing, or loss of balance or coordination. This is not a complete list of risks or side effects associated with Abilify.

For more specific information consult with your healthcare provider. What is the least expensive equivalent of Abillify? Abilify aripiprazole is an antipsychotic medication that is used to treat schizophrenia, bipolar disorder, and major depressive disorder. Abilify may also be used to treat irritability, aggression, and mood swings.

Unfortunately, there is no generic for Abilify at this time. Thus, there is no other alternative that contains the same ingredient as Abilify. If Abilify is too costly, it would be best for you to speak with your doctor to see if they would be willing to switch Abilify to another medication which may have a generic available. Megan Uehara, PharmD Q: My boyfriend just started taking Abilify yesterday. Last night he didn't sleep. He took another pill tonight and again he can't sleep.

Can he take a sleep aid that contains 25 mg of diphenhydramine? Abilify aripiprazole is an atypical antipsychotic agent which is used to treat schizophrenia and bipolar disorder.

Insomnia difficulty sleeping is a potential side effect of Abilify. Other common side effects of Abilify may include headache, drowsiness, dizziness, fatigue, tremor, extrapyramidal symptoms involuntary movements , agitation, nausea, vomiting and constipation.

Easy to qualify for our Prescription Assistance program if you.

Offer void where prohibited by law, taxed, or restricted. Call your healthcare provider right away if you have any of these symptoms. No dosage adjustment of omeprazole is required when administered concomitantly with aripiprazole. The recommended starting dose for treating major depression when used along with an antidepressant in adults is 2 mg to 5 mg once daily. By decreasing these chemicals, 25mg abilify, Abilify works to control the symptoms associated with schizophrenia and bipolar disorder. General Disorders and Administration Site Conditions: 25mg neonates recovered within hours or days without specific treatment; others required prolonged hospitalization. Liquid preparations of this product may contain sugar. Abilify is also used abilify or combined with other medications to treat mania or mania and depression in people who have bipolar disorder. Lori Poulin, PharmD Q:

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