Zidovudine Single mg doses and multiple mg or mg doses of azithromycin had little effect on the plasma pharmacokinetics or urinary excretion of zidovudine or its glucuronide metabolite.

However, administration of azithromycin increased the concentrations of phosphorylated zidovudine, the clinically active metabolite, in peripheral blood mononuclear cells. The clinical significance of this finding is unclear, but it may be of benefit to patients. Azithromycin does not interact significantly with the hepatic cytochrome P system. It is not believed to undergo the pharmacokinetic drug interactions as seen with erythromycin and other macrolides. Hepatic cytochrome P induction or inactivation via cytochrome-metabolite complex does not occur with azithromycin.

Ergot Due to the theoretical possibility of ergotism, the concurrent use of azithromycin with ergot derivatives is not recommended see Section 4. Pharmacokinetic studies have been conducted between azithromycin and the following drugs known to undergo significant cytochrome P mediated metabolism.

Due to the theoretical possibility of ergotism, the concurrent use of azithromycin with ergot derivatives is not recommended see section 4. Astemizole, alfentanil There are no known data on interactions with astemizole or alfentanil. Caution is advised in the co-administration of these medicines with Azithromycin because of the known enhancing effect of these medicines when used concurrently with the macrolid antibiotic erythromycin.

Atorvastatin Coadministration of atorvastatin 10 mg daily and azithromycin mg daily did not alter the plasma concentrations of atorvastatin based on a HMG CoA-reductase inhibition assay.

However, post-marketing cases of rhabdomyolysis in patients receiving azithromycin with statins have been reported. Carbamazepine In a pharmacokinetic interaction study in healthy volunteers, no significant effect was observed on the plasma levels of carbamazepine or its active metabolite in patients receiving concomitant azithromycin. Because macrolides inhibit this enzyme, concomitant administration of cisapride may cause the increase of QT interval prolongation, ventricular arrhythmias and torsades de pointes.

Cimetidine In a pharmacokinetic study investigating the effects of a single dose of cimetidine, given 2 hours before azithromycin, on the pharmacokinetics of azithromycin, no alteration of azithromycin pharmacokinetics was seen.

Coumarin-Type Oral Anticoagulants In a pharmacokinetic interaction study, azithromycin did not alter the anticoagulant effect of a single 15 mg dose of warfarin administered to healthy volunteers. There have been reports received in the post-marketing period of potentiated anticoagulation subsequent to coadministration of azithromycin and coumarin-type oral anticoagulants.

Although a causal relationship has not been established, consideration should be given to the frequency of monitoring prothrombin time when azithromycin is used in patients receiving coumarin-type oral anticoagulants.

Consequently, caution should be exercised before considering concurrent administration of these drugs. If coadministration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.

Efavirenz Coadministration of a mg single dose of azithromycin and mg efavirenz daily for 7 days did not result in any clinically significant pharmacokinetic interactions. Fluconazole Coadministration of a single dose of mg azithromycin did not alter the pharmacokinetics of a single dose of mg fluconazole.

Indinavir Coadministration of a single dose of mg azithromycin had no statistically significant effect on the pharmacokinetics of indinavir administered as mg three times daily for 5 days. Methylprednisolone In a pharmacokinetic interaction study in healthy volunteers, azithromycin had no significant effect on the pharmacokinetics of methylprednisolone. Nelfinavir Coadministration of azithromycin mg and nelfinavir at steady state mg three times daily resulted in increased azithromycin concentrations.

No clinically significant adverse effects were observed and no dose adjustment is required. Rifabutin Coadministration of azithromycin and rifabutin did not affect the serum concentrations of either drug.

Neutropenia was observed in subjects receiving concomitant treatment of azithromycin and rifabutin. Although neutropenia has been associated with the use of rifabutin, a causal relationship to combination with azithromycin has not been established see Section 4. Consult your doctor before breast -feeding. What should I know regarding pregnancy, nursing and administering Clarithromycin to children or the elderly? Interactions Drug interactions may change how your medications work or increase your risk for serious side effects.

This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: Many drugs besides clarithromycin may affect the heart rhythm QT prolongation , including amiodarone , dofetilide , pimozide , procainamide , quinidine , sotalol , among others.

Other medications can affect the removal of clarithromycin from your body, which may affect how clarithromycin works. Examples include rifamycins such as rifabutin , efavirenz , nevirapine , among others. Clarithromycin can slow down the removal of other medications from your body, which may affect how they work.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics such as rifampin , rifabutin can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control , ask your doctor or pharmacist for more details. Does Clarithromycin interact with other medications?

Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call Otherwise, call a poison control center right away. US residents can call their local poison control center at Canada residents can call a provincial poison control center.

Notes Do not share this medication with others. This medication has been prescribed for your current condition only.

Do not use it later for another infection unless your doctor directs you to do so. A different medication may be necessary in that case. Consult your doctor for more details. Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Do not double the dose to catch up. Storage Store at room temperature away from light and moisture.

Do not store in the bathroom. Keep all medications away from children and pets. There have been reports of infantile hypertrophic pyloric stenosis IHPS occurring in infants following erythromycin therapy. Since erythromycin may be used in the treatment of conditions in infants which are associated with significant mortality or morbidity such as pertussis or chlamydia , the benefit of erythromycin therapy needs to be weighed against the potential risk of developing IHPS.

Parents should be informed to contact their physician if vomiting or irritability with feeding occurs. QT Prolongation Erythromycin has been associated with prolongation of the QT interval and infrequent cases of arrhythmia. Cases of torsades de pointes have been spontaneously reported during post marketing surveillance in patients receiving erythromycin. Fatalities have been reported. Erythromycin should be avoided in patients with known prolongation of the QT interval, patients with ongoing proarrhythmic conditions such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and in patients receiving Class IA quinidine, procainamide or Class III dofetilide, amiodarone, sotalol antiarrhythmic agents.

Elderly patients may be more susceptible to drug-associated effects on the QT interval see section 4. Patients receiving erythromycin concurrently with drugs which can cause prolongation of the QT interval should be carefully monitored.

The concomitant use of erythromycin with some of these drugs is contraindicated see sections 4.

Azithromycin 250 mg film-coated tablet

Schedule Update Mar 1, In situations where the concomitant use of erythromycin with statins cannot be avoided, it is recommended to prescribe azithromycin lowest registered dose of the statin. For the best effect, take this antibiotic at evenly spaced times. Methylprednisolone In a pharmacokinetic interaction study in healthy volunteers, azithromycin had no significant effect on the pharmacokinetics of methylprednisolone. Lactation Azithromycin has been reported to be secreted into human breast milk, but there are no adequate and well-controlled clinical studies in nursing women that have characterized the pharmacokinetics of azithromycin excretion into human breast milk, azithromycin 500mg ulotka. Ulotka In normal healthy male volunteers, there was no evidence of an effect of azithromycin mg daily for 3 days on the AUC and Cmax of sildenafil or its major circulating metabolite. QT Prolongation Erythromycin has been associated with ulotka of the QT interval and infrequent cases azithromycin arrhythmia. Careful medical history is necessary since CDAD has been reported to occur over 500mg months after 500mg administration of antibacterial agents. Consult your doctor for more details. Tell your doctor if you develop signs of infection such as fever or night sweats.

Azithromycin Warning

Azithromycin 200mg/5ml Powder for Oral Suspension

The frequency grouping is defined using the following convention: If you notice other effects not listed above, azithromycin 500mg ulotka, contact your 500mg or pharmacist. However, administration of azithromycin increased the concentrations of phosphorylated zidovudine, the clinically active metabolite, in peripheral blood mononuclear ulotka. Precautions Before taking clarithromycintell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics such as azithromycinazithromycin ; or if you azithromycin any other allergies. Qualitative and quantitative composition Azithromycin mg film-coated tablet ulotka film-coated tablet contains: Claritromicina - Wikipedia Clarithromycin g. 500mg not double the dose to catch up. Children 500mg tablets should only be administered to children weighing more than 45 kg when normal adult dose should be used. Consequently, caution should be exercised before considering concurrent administration of these drugs. The frequency grouping is defined using the following convention: Lactation Azithromycin has been reported to be secreted into human breast milk, but there are no adequate and well-controlled clinical studies in nursing women that have characterized the pharmacokinetics of azithromycin excretion into human breast milk. Name of the medicinal product Azithromycin mg film-coated ulotka 2, azithromycin 500mg ulotka.

Antibiotic Azithromycin

Clarithromycin 250 mg ulotka

This condition may occur during treatment or weeks to months after treatment has stopped. Triazolam In 14 500mg volunteers, coadministration of azithromycin mg on Day 1 and mg on Azithromycin 2 with 0, azithromycin 500mg ulotka. For children under 45 kg other pharmaceutical forms of azithromycin, e. Klacid, mg, tabletki powlekane Ulotka doczona do opakowania: Azithromycin mg film-coated tablet may be taken with food. Azithromycin administration should be stopped if liver dysfunction has emerged. Erythromycin is contraindicated in patients receiving the HmG-CoA reductase inhibitors lovastatin and simvastatin see section 4. However, administration of azithromycin increased the concentrations of phosphorylated zidovudine, the clinically active metabolite, in peripheral blood mononuclear cells. It is not believed to undergo the pharmacokinetic drug interactions as seen with erythromycin and other macrolides. There have been rare cases reported where the possibility of such an interaction could not be entirely excluded; however there was no specific evidence that such an interaction had occurred. Indinavir Coadministration of a single dose of mg azithromycin had no statistically significant effect on the pharmacokinetics of indinavir azithromycin as mg three times daily for 5 days. Before using this medicationtell your doctor or pharmacist your medical history, especially of: Clarithromycin Klacid granules for oral liquid change of strength. Properly discard this 500mg when it is expired ulotka no longer needed. There have been reports suggesting erythromycin does not reach the foetus in adequate concentrations to prevent congenital syphilis. Methylprednisolone In a pharmacokinetic interaction study in healthy volunteers, azithromycin had no significant effect on the ulotka of methylprednisolone. There are no data concerning the possibility of an interaction between ergot and azithromycin.

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