The dosage can be increased every 7 to 14 days until the maximum dosage of mg per day is reached. Dosage for chronic stable angina Adult dosage ages 18—64 years The starting dose is 30 mg or 60 mg by mouth once per day. Special considerations If you have liver disease, body may have trouble clearing nifedipine from your blood.
This may cause the amount of nifedipine in your blood to be too high. Your doctor may adjust your dose to keep the amount of nifedipine in your body at a safe level. Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice.
Always to speak with your doctor or pharmacist about dosages that are right for you. Advertisement Take as directed Take as directed Nifedipine oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you take this drug to treat high blood pressure, your blood pressure may increase. This can raise your risk of health problems such as heart attack or stroke. If you take this drug to treat angina, your chest pain may get worse.
Your medication may not work as well or may stop working completely. The increased peripheral vascular resistance that is an underlying cause of hypertension results from an increase in active tension in the vascular smooth muscle. Studies have demonstrated that the increase in active tension reflects an increase in cytosolic free calcium.
Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. Stores of intracellular calcium in vascular smooth muscle are limited and thus dependent upon the influx of extracellular calcium for contraction to occur.
The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. Pharmacokinetics and Metabolism Nifedipine is completely absorbed after oral administration. Plasma drug concentrations rise at a gradual, controlled rate after a Nifedipine Extended-release Tablet dose and reach a plateau at approximately six hours after the first dose.
For subsequent doses, relatively constant plasma concentrations at this plateau are maintained with minimal fluctuations over the hour dosing interval. About a fourfold higher fluctuation index ratio of peak to trough plasma concentration was observed with the conventional immediate-release nifedipine capsule at t.
Administration of the Nifedipine Extended-release Tablet in the presence of food slightly alters the early rate of drug absorption, but does not influence the extent of drug bioavailability. Markedly reduced GI retention time over prolonged periods i. Pharmacokinetics of Nifedipine Extended-release Tablets are linear over the dose range of 30 to mg in that plasma drug concentrations are proportional to dose administered.
There was no evidence of dose dumping either in the presence or absence of food for over subjects in pharmacokinetic studies. All the savings accrued through various measures translates to the cheaper price of prescription drugs at Rx 2 Go Pharmacy. You can also get additional price benefits by taking advantage of the volume discounts we offer. Related products Buy Metoprolol Tartr Metoprolol Tartrate blocks selectively beta 1 receptors.
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Tell your doctor if your condition worsens for example, your chest pain worsens or is more frequent. What conditions does Nifedipine treat? If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To reduce dizziness and lightheadedness , get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: Tell your doctor right away if any of these rare but very serious side effects occur: Although this medication is effective in preventing chest pain angina , some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose.
Get medical help right away if you experience: A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at List Nifedipine side effects by likelihood and severity.
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