Positive direct Coombs' tests have been reported during treatment with the cephalosporin antibiotics. It should be recognized that a positive Coombs' test may be due to the drug, e. Cefaclor should be administered with caution in the presence of markedly impaired renal function.
Since the half-life of Cefaclor in anuria is 2. Clinical experience with Cefaclor under such conditions is limited; therefore, careful clinical observation and laboratory studies should be made.
Antibiotics, including cephalosporins, should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Information for Patients Patients should be counseled that antibacterial drugs including Cefaclor for Oral Suspension should only be used to treat bacterial infections.
They do not treat viral infections e. When Cefaclor for Oral Suspension is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping dose or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by Cefaclor for Oral Suspension or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued.
Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. There have been reports of increased anticoagulant effect when Cefaclor and oral anticoagulants were administered concomitantly.
Carcinogenesis, Mutagenesis, Impairment of Fertility Studies have not been performed to determine potential for carcinogenicity, mutagenicity, or impairment of fertility. Pregnancy Teratogenic Effects Pregnancy Category B Reproduction studies have been performed in mice and rats at doses up to 12 times the human dose and in ferrets given 3 times the maximum human dose and have revealed no harm to the fetus due to Cefaclor.
There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Labor and Delivery The effect of Cefaclor on labor and delivery is unknown. Nursing Mothers Small amounts of Cefaclor have been detected in mother's milk following administration of single mg doses.
Average levels were 0. Trace amounts were detected at 1 hour. The effect on nursing infants is not known. Caution should be exercised when Cefaclor is administered to a nursing woman. Pediatric Use Safety and effectiveness of this product for use in infants less than 1 month of age have not been established.
Geriatric Use Of the 3, patients in clinical studies of Cefaclor, No overall differences in safety or effectiveness were observed between these subjects and younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
Adverse Reactions Adverse effects considered to be related to therapy with Cefaclor are listed below: Antibiotics, including cefaclor, should be administered cautiously to any patient who has demonstrated some form of allergy , particularly to drugs. Clostridium difficile associated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including Cefaclor for Oral Suspension, USP, and may range in severity from mild diarrhea to fatal colitis.
Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. Hypertoxin-producing strains of C. CDAD must be considered in all patients who present with diarrhea following antibiotic use.
Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. Prolonged use of cefaclor may result in the overgrowth of nonsusceptible organisms.
Careful observation of the patient is essential. If superinfection occurs during therapy, appropriate measures should be taken. Extended-release cefaclor has been associated with increased BUN 0. Cephalosporins as a class have been associated with toxic nephropathy, reversible interstitial nephritis, and renal dysfunction.
Extended-release cefaclor the active ingredient contained in Ceclor CD has been associated with increased eosinophils 0. Cephalosporins as a class have been associated with hemorrhage and pancytopenia.
Extended-release cefaclor the active ingredient contained in Ceclor CD has been associated with vaginitis 2. Cephalosporins as a class have been associated with false-positive tests for urine glucose. Extended release cefaclor the active ingredient contained in Ceclor CD has been associated with headache in 4.
Some cephalosporins have been associated with seizures, primarily when dosages were not reduced in renally impaired patients.
Tags: cozaar generic price oxycodone retail price buy prilosec online canada
© Copyright 2017 Ceclor 12 h suspensión pediátrica 375mg *** morbidevoci.ch.