The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For attention deficit hyperactivity disorder ADHD: For oral dosage form extended-release tablets: Teenagers and children 6 years of age and older—At first, 0. Your doctor will increase your dose as needed.
Children younger than 6 years of age—Use and dose must be determined by your doctor. For high blood pressure: For oral dosage form extended-release suspension: Your doctor may adjust your dose as needed. The usual dose is 0. Children—Use and dose must be determined by your doctor.
For oral dosage form tablets: Missed Dose If you miss a dose of this medicine, take it as soon as possible. Minor Alpha blockers as a class may reduce heart rate and blood pressure. While no specific drug interactions have been identified with systemic agents and apraclonidine during clinical trials, it is theoretically possible that additive blood pressure reductions could occur when apraclonidine is combined with the use of antihypertensive agents.
Patients using cardiovascular drugs concomitantly with apraclonidine should have their pulse and blood pressure monitored periodically. Minor Due to aripiprazole's antagonism at alpha 1-adrenergic receptors, the drug may enhance the hypotensive effects of alpha-blockers and other antihypertensive agents. Major Sympathomimetics, such as epinephrine, can antagonize the antihypertensive effects of clonidine when administered concomitantly.
Moderate Secondary to alpha-blockade, asenapine can produce vasodilation that may result in additive effects during concurrent use of antihypertensive agents. The potential reduction in blood pressure can precipitate orthostatic hypotension and associated dizziness, tachycardia, and syncope.
If concurrent use of asenapine and antihypertensive agents is necessary, patients should be counseled on measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning and rising slowly from a seated position. Close monitoring of blood pressure is recommended until the full effects of the combination therapy are known. Use caution during coadministration. Moderate Cutaneous vasodilation induced by niacin may become problematic if high-dose niacin is used concomitantly with other antihypertensive agents.
This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise. Clonidine has been shown to inhibit niacin-induced flushing.
The interaction is harmless unless niacin augments the hypotensive actions of clonidine. Moderate Baclofen has been associated with hypotension. Concurrent use with baclofen and antihypertensive agents may result in additive hypotension. Dosage adjustments of the antihypertensive medication may be required.
Moderate Epidural clonidine may prolong the duration of action of local anesthetics, including both sensory and motor blockade. Major Benzphetamine can increase both systolic and diastolic blood pressure and may counteract the activity of clonidine. This represents a pharmacodynamic, and not a pharmacokinetic, interaction.
Close monitoring of blood pressure, especially in patients who are taking antihypertensive agents, may be needed. Major Monitor heart rate in patients receiving concomitant clonidine and agents known to affect sinus node function or AV nodal conduction e.
Severe bradycardia resulting in hospitalization and pacemaker insertion has been reported during combination therapy with clonidine and other sympatholytic agents. Concomitant use of clonidine with beta-blockers can also cause additive hypotension. Beta-blockers should not be substituted for clonidine when modifications are made in a patient's antihypertensive regimen because beta-blocker administration during clonidine withdrawal can augment clonidine withdrawal, which may lead to a hypertensive crisis.
If a beta-blocker is to be substituted for clonidine, clonidine should be gradually tapered and the beta-blocker should be gradually increased over several days to avoid the possibility of rebound hypertension; administration of beta-blockers during withdrawal of clonidine can precipitate severe increases in blood pressure as a result of unopposed alpha stimulation. Moderate Patients on antihypertensive agents receiving bortezomib treatment may require close monitoring of their blood pressure and dosage adjustment of their medication.
During clinical trials of bortezomib, hypotension was reported in roughly 12 percent of patients. Moderate Although no specific interactions have been documented, bosentan has vasodilatory effects and may contribute additive hypotensive effects when given with central-acting adrenergic agents e.
Moderate Due to brexpiprazole's antagonism at alpha 1-adrenergic receptors, the drug may enhance the hypotensive effects of alpha-blockers and other antihypertensive agents.
Minor Bromocriptine has only minimal affinity for adrenergic receptors; however, hypotension can occur during bromocriptine administration. It is unknown if bromocriptine is the exact cause of this effect. However, the drug should be used cautiously with other medications known to lower blood pressure such as antihypertensive agents. Monitoring of blood pressure should be considered, especially during the initial weeks of concomitant therapy.
Bromocriptine suppresses prolactin secretion from the anterior pituitary gland; therefore, the reduction in prolactin levels resulting from bromocriptine administration may be antagonized by prolactin-enhancing antihypertensive medications such as methyldopa and reserpine.
Moderate Clonidine may potentiate or weaken the hypoglycemic effects of antidiabetic agents, and may also mask the signs and symptoms of hypoglycemia. Moderate Concomitant use of antihypertensive agents with levodopa can result in additive hypotensive effects. Moderate Clonidine can produce bradycardia and should be used cautiously in patients who are receiving other drugs that lower the heart rate such as cardiac glycosides.
Moderate Orthostatic vital signs should be monitored in patients who are at risk for hypotension, such as those receiving cariprazine in combination with antihypertensive agents. Atypical antipsychotics may cause orthostatic hypotension and syncope, most commonly during treatment initiation and dosage increases. Patients should be informed about measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning, or rising slowly from a seated position.
Consider a cariprazine dose reduction if hypotension occurs. Moderate If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control.
Doses of antihypertensive medications may require adjustment in patients receiving concurrent NSAIDs. NSAIDs, to varying degrees, have been associated with an elevation in blood pressure. This effect is most significant in patients receiving concurrent antihypertensive agents and long-term NSAID therapy. NSAIDs cause a dose-dependent reduction in prostaglandin formation, which may result in a reduction in renal blood flow leading to renal insufficiency and an increase in blood pressure that are often accompanied by peripheral edema and weight gain.
Patients who rely upon renal prostaglandins to maintain renal perfusion may have acute renal blood flow reduction with NSAID usage.
Elderly patients may be at increased risk of adverse effects from combined long-term NSAID therapy and antihypertensive agents, especially diuretics, due to age-related decreases in renal function and an increased risk of stroke and coronary artery disease.
Major Avoid coadministration of ceritinib with clonidine due to the risk of additive bradycardia. If unavoidable, monitor heart rate and blood pressure regularly. An interruption of ceritinib therapy, dose reduction, or discontinuation of therapy may be necessary. Moderate Local anesthetics may cause additive hypotension in combination with antihypertensive agents.
Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Moderate Phenothiazines may produce alpha-adrenergic blockade and appear to have additive hypotensive or CNS effects when administered concurrently with central-acting adrenergic agents.
Moderate Clozapine used concomitantly with the antihypertensive agents can increase the risk and severity of hypotension by potentiating the effect of the antihypertensive drug. Moderate Fish oil supplements may cause mild, dose-dependent reductions in blood pressure in untreated hypertensive patients.
Additive reductions in blood pressure may be seen when fish oils are used in a patient already taking antihypertensive agents. Moderate High doses of fish oil supplements may produce a blood pressure lowering effect. It is possible that additive reductions in blood pressure may be seen when fish oils are used in a patient already taking antihypertensive agents.
Moderate Co-enzyme Q10, ubiquinone CoQ10 may lower blood pressure. CoQ10 use in combination with antihypertensive agents may lead to additional reductions in blood pressure in some individuals. Patients who choose to take CoQ10 concurrently with antihypertensive medications should receive periodic blood pressure monitoring. Patients should be advised to inform their prescriber of their use of CoQ Moderate Cyclobenzaprine is structurally related to the tricyclic antidepressants and Clonidine's antihypertensive effect can be reduced by TCAs.
Caution is warranted when combining cyclobenzaprine with clonidine. Minor Clonidine can inhibit cyclosporine-induced glomerular vasoconstriction and has been shown to offset cyclosporine-induced nephrotoxicity. Clonidine may adversely affect cyclosporine pharmacokinetics; limited data suggest that cyclosporine concentrations increase - dramatically, in some cases - when clonidine is added. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements.
You should avoid over-the-counter [OTC] medicines for appetite control, asthma , colds, cough , hay fever , or sinus problems, since they may tend to increase your blood pressure. Clonidine will add to the effects of alcohol and other central nervous system CNS depressants. CNS depressants are medicines that slow down the nervous system and may cause drowsiness.
Some examples of CNS depressants are antihistamines or medicine for hay fever , allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates or medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics.
Check with your doctor before taking any of the above while you are using this medicine. Clonidine may cause some people to become drowsy or less alert than they are normally. This is more likely to happen when you begin to take it or when you increase the amount of medicine you are taking. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.
Before having any kind of surgery including dental surgery or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine.
This medicine may cause dryness of the eyes. If you wear contact lenses, this may be a problem for you.
Talk to your doctor if you wear contact lenses, and discuss how to treat the dryness. Dizziness , lightheadedness , or fainting may occur after you take this medicine, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help, but if the problem continues or gets worse, check with your doctor. The dizziness , lightheadedness, or fainting is also more likely to occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot.
While you are taking clonidine, be careful to limit the amount of alcohol you drink. Also, use extra care not to become dehydrated or overheated during exercise or hot weather or if you must stand for a long time. If you develop a skin rash, hives, or any allergic reaction to this medicine, stop taking the medicine and check with your doctor as soon as possible. Clonidine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute.
However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. When discontinuing therapy with clonidine hydrochloride, the physician should reduce the dose gradually over 2 to 4 days to avoid withdrawal symptomatology. An excessive rise in blood pressure following discontinuation of clonidine hydrochloride therapy can be reversed by administration of oral clonidine hydrochloride or by intravenous phentolamine.
If therapy is to be discontinued in patients receiving a beta-blocker and clonidine concurrently, the beta-blocker should be withdrawn several days before the gradual discontinuation of clonidine hydrochloride. Because children commonly have gastrointestinal illnesses that lead to vomiting, they may be particularly susceptible to hypertensive episodes resulting from abrupt inability to take medication.
In patients who have developed localized contact sensitization to transdermal clonidine, substitution of oral clonidine hydrochloride therapy may be associated with the development of a generalized skin rash. In patients who develop an allergic reaction to transdermal clonidine, substitution of oral clonidine hydrochloride may also elicit an allergic reaction including generalized rash, urticaria, or angioedema.
Clonidine hydrochloride should be used with caution in patients with severe coronary insufficiency, conduction disturbances, recent myocardial infarction, cerebrovascular disease or chronic renal failure. Administration of clonidine hydrochloride should be continued to within four hours of surgery and resumed as soon as possible thereafter. Blood pressure should be carefully monitored during surgery and additional measures to control blood pressure should be available if required.
Clonidine may potentiate the CNS-depressive effects of alcohol, barbiturates or other sedatives. If a patient receiving clonidine hydrochloride is also taking tricyclic antidepressants, the hypotensive effect of clonidine may be reduced, necessitating an increase in the clonidine dosage. Due to a potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.
Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats see Toxicology. In several studies with oral clonidine hydrochloride, a dose dependent increase in the incidence and severity of spontaneous retinal degeneration was seen in albino rats treated for six months or longer. Tissue distribution studies in dogs and monkeys showed a concentration of clonidine in the choroid. In view of the retinal degeneration seen in rats, eye examinations were performed during clinical trials in patients before, and periodically after, the start of clonidine therapy.
In of these patients, the eye examinations were carried out over periods of 24 months or longer. Except for some dryness of the eyes, no drug-related abnormal ophthalmological findings were recorded and, according to specialized tests such as electroretinography and macular dazzle, retinal function was unchanged. In combination with amitriptyline, clonidine hydrochloride administration led to the development of corneal lesions in rats within 5 days.
There was no evidence of genotoxicity in the Ames test for mutagenicity or mouse micronucleus test for clastogenicity. Reproduction studies performed in rabbits at doses up to approximately 3 times the oral maximum recommended daily human dose MRDHD of clonidine hydrochloride produced no evidence of teratogenic or embryotoxic potential in rabbits.
Increased resorptions were not associated with treatment at the same or at higher dose levels up to 3 times the oral MRDHD when dams were treated on gestation days 6 to No adequate, well controlled studies have been conducted in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Foetal malformations did not occur. Moderate Concurrent use of tizanidine with antihypertensive agents can result in significant hypotension. Adverse events have been ranked under headings of frequency using the following convention: To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. This can be therapeutically advantageous, but dosages must be adjusted accordingly. Warnings Withdrawal Patients should be instructed not to discontinue therapy without consulting their physician. Moderate Orthostatic vital signs should be monitored in patients who are at risk for hypotension, such as those receiving cariprazine in clonidine with antihypertensive agents, clonidine (catapres) 0.1mg tablet. It cannot be ruled out that concomitant administration of a beta-receptor blocker will cause or potentiate peripheral vascular disorders. Close monitoring of blood pressure is recommended until the full effects of the combination therapy are known. Most people with high blood pressure do not feel sick. Serious adverse events, including sudden death, have been reported in concomitant use with methylphenidate. If you miss 2 or more doses in a row, contact your doctor right away. If Catapres is being given concurrently with a beta-blocker, Catapres should not be discontinued until several days after the withdrawal of the beta-blocker. Decreased dosage of the antihypertensive agent may be required in some patients. Moderate Further reductions in blood pressure may occur when inhaled iloprost is administered to patients receiving other (catapres) agents. Clonidine's antihypertensive effect can be reduced by 0.1mg antidepressants; occasionally, the hypertension will occur within the tablet few days of combined therapy.
Clinical clonidine Your doctor may do tests during your treatment with 0.1mg drug. It has been shown to cross the blood-brain barrier in rats. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical tablet for which you are using the medicine. Talk to your tablet if can you buy diamox peru wear contact lenses, clonidine (catapres) 0.1mg tablet, and discuss how to treat the dryness. Dryness of the nasal mucosa was rarely reported. Each (catapres) for oral administration contains ammonium chloride, colloidal silicon dioxide, croscarmellose sodium Type A (catapres), magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate. 0.1mg intravenous administration, (catapres) displays biphasic disposition with 0.1mg distribution half-life of about 20 minutes and an elimination half-life ranging clonidine 12 to 16 hours. Since only a minimal amount of clonidine is removed during routine hemodialysis, there is no need to give supplemental clonidine following dialysis. Clonidine acutely stimulates growth hormone release in both children and adults, but does not produce a chronic elevation of growth tablet with long-term use, clonidine (catapres) 0.1mg tablet. Take clonidine in the morning and at bedtime: In Canada - Call your doctor for medical advice about side effects. Slowing of the pulse rate has been observed in most patients given clonidine, but the drug does not alter normal hemodynamic response to exercise. If you miss more than one dose of clonidine tablets, check with your doctor right away. Causal relationship and relevance for clonidine oral tablets have not been established. There was no evidence clonidine genotoxicity in the Ames test for mutagenicity or mouse micronucleus test for clastogenicity, clonidine (catapres) 0.1mg tablet.
Bradycardia, clonidine (catapres) 0.1mg tablet, congestive heart failure, clonidine abnormalities 0.1mg. Overdosage Hypertension may develop early and may be followed by hypotension, bradycardia, respiratory depression, hypothermia, drowsiness, decreased or absent reflexes, weakness, irritability and miosis. Causal relationship and relevance for antihypertensive treatment have not been established. Therefore the use of clonidine is not recommended in paediatric tablets under 18 years. Fatigue, fever, headache, pallor, weakness, and withdrawal syndrome. Clonidine injection epidural clonidine is not recommended for obstetrical, postpartum, or perioperative pain management. Warnings Withdrawal Patients should be instructed not to discontinue therapy without consulting their physician. The following is a general guide to its administration. However, if overdose is suspected, seek emergency medical attention. Initially 2 (catapres) twice daily. Warnings Withdrawal Patients should be instructed not to discontinue therapy without consulting their physician.
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