Pregnancy and Fluconazole In general, it's not recommended that pregnant women take this medication. Fluconazole can harm the fetus and should only be taken in situations when there are no other safer options available. Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication. Fluconazole has been found to pass into breast milk, so alert your physician if you are breastfeeding or plan to breastfeed.
Other side effects include: Segera setelah itu, interval dosis harus dilipatgandakan sampai dengan 48 jam dengan kata lain, dosis dikurangi setengahnya. Ruam pada kulit bisa terjadi tapi jarang. Flukonazol bisa menyebabkan kerusakan hati pada kasus jarang. Fungsi hati harus dimonitor setelah beberapa hari penggunaan obat. Fluconazole adalah jenis obat yang dapat ditoleransi dengan baik. Elevasi asimptomatik transient tingkat transaminase serum relatif biasa terjadi pada pasien penderita AIDS, dan pengobatan harus dihentikan pada pasien penderita hepatitis simptomatik atau penderita gangguan fungsi hati.
Pasien penderita kanker atau AIDS memiliki kemungkinan untuk mengidap sindrom Stevens-Johnson fatal exfoliative skin rashes , namun hubungan sebab akibat penyakit ini dengan fluconazole belumlah jelas, terutama jika penanganan dilakukan secara terus-menerus dengan obat-obatan jenis lain.
Ada baiknya untuk menghentikan konsumsi fluconazole pada pasien penderita infeksi jamur superficial, di mana pasien tersebut mengalami pengelupasan kulit. Berbeda dengan ketoconazole, fluconazole tidak menghambat metabolisme adrenal maupun steroid testicular manusia. Syaratnya, obat ini dikonsumsi dengan dosis yang tepat.
Fluconazole mg was administered daily from days 9 through Fluconazole did not affect terfenadine plasma concentrations. There was no change in cardiac repolarization as measured by Holter QTc intervals. Another study at a mg and mg daily dose of fluconazole demonstrated that fluconazole taken in doses of mg per day or greater significantly increases plasma levels of terfenadine when taken concomitantly.
Oral Hypoglycemics The effects of fluconazole on the pharmacokinetics of the sulfonylurea oral hypoglycemic agents tolbutamide, glipizide, and glyburide were evaluated in three placebo-controlled studies in normal volunteers.
All subjects received the sulfonylurea alone as a single dose and again as a single dose following the administration of fluconazole mg daily for 7 days. Tolbutamide In 13 normal male volunteers, there was significant increase in tolbutamide mg single dose AUC and Cmax following the administration of fluconazole.
Glyburide The AUC and Cmax of glyburide 5 mg single dose were significantly increased following the administration of fluconazole in 20 normal male volunteers.
Five subjects required oral glucose following the ingestion of glyburide after 7 days of fluconazole administration. Rifabutin There have been published reports that an interaction exists when fluconazole is administered concomitantly with rifabutin, leading to increased serum levels of rifabutin.
Tacrolimus There have been published reports that an interaction exists when fluconazole is administered concomitantly with tacrolimus, leading to increased serum levels of tacrolimus.
Cisapride A placebo-controlled, randomized, multiple-dose study examined the potential interaction of fluconazole with cisapride. Two groups of 10 normal subjects were administered fluconazole tablets mg daily or placebo.
Cisapride 20 mg four times daily was started after 7 days of fluconazole or placebo dosing. Fluconazole significantly increased the QTc interval in subjects receiving cisapride 20 mg four times daily for 5 days.
Midazolam The effect of fluconazole on the pharmacokinetics and pharmacodynamics of midazolam was examined in a randomized, cross-over study in 12 volunteers. In the study, subjects ingested placebo or mg fluconazole on Day 1 followed by mg daily from Day 2 to Day 6. In addition, a 7. The psychomotor effects of midazolam were significantly increased after oral administration of midazolam but not significantly affected following intravenous midazolam.
A second randomized, double-dummy, placebo-controlled, cross-over study in three phases was performed to determine the effect of route of administration of fluconazole on the interaction between fluconazole and midazolam. In each phase the subjects were given oral fluconazole tablets mg and intravenous saline; oral placebo and intravenous fluconazole mg; and oral placebo and IV saline.
Fluconazole telah terbukti bermanfaat untuk perawatan prophylaktat terhadap penyakit candidosis yang diderita oleh pasien pengidap neutropenik.
Fluconazole tidak tidak efektif untuk mengobati aspergillosis dan mucormycosis. Fluconazole merupakan jenis obat-obatan yang ampuh untuk mengatasi meningitis cryptococcal, tetapi tidak boleh dijadikan prioritas utama untuk pasien pengidap AIDS kecuali jika terdapat alasan-alasan tertentu.
Fluconazole terbukti lebih efektif dan lebih dapat ditoleransi dibandingkan amphotericin B untuk mengobati atau mencegah terjadinya cryptococcosis pada pasien penderita AIDS. Fluconazole saat ini menjadi jenis obat yang menjadi pilihan banyak dokter untuk mengobati pasien penderita meningitis coccidioidal. Syaratnya, pasien tersebut harus tetap mengkonsumsi fluconazole selama hidupnya agar mencegah munculnya kembali penyakit yang sama. Dosis tunggal mg.
Modifikasi dosis perlu dilakukan pada pasien dengan gangguan ginjal.. Fluconazole merangsang terjadinya absorpsi secara sempurna pada saat dilakukan pengobatan secara oral, sehingga jenis pengobatan oral menjadi prioritas utama. Namun demikian, sejumlah praktisi klinik telah menggunakan dosis yang lebih tinggi lagi untuk mengatasi infeksi-infeksi yang membahayakan nyawa pasien.
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