I am interested in potential long term negative effects. I am 56 and have had a sleep analysis -- no sleep apnea. Lorazepam used in small dosage are used to treat sleep disorders. This medication can become addicting is used over a long period of time but can be easily stopped by the proper tapering dose to eliminate any side effects from stopping this medication. Do not just stop taking with out first talking with your Health Care Provider.
Used in small dosages, Lorazepam works quite well in treating sleep disorders, such as insomnia. Lorazepam can become addicting over a long period of time; however, it can easily be stopped by properly tapering down the dosage without any serious side effects. Do not abruptly stop the taking Lorazepam. Only use this medications they way you have been instructed by your health care provider. Do not increase dosage without talking to your health care provider first, if you feel you are not getting the same results after using this medication for a period of time.
I have been taking this drug for a couple of years but only at this small dosage. Could this lend to a small weight gain? Also, my stomach is bloated and hard lately. I do suffer from symtomatic diverticulosis.
Extension of the treatment period should not take place without reevaluation of the need for continued therapy. Continuous long-term use of product is not recommended. Abrupt discontinuation of product should be avoided and a gradual dosage-tapering schedule followed after extended therapy. Abrupt termination of treatment may be accompanied by withdrawal symptoms.
There is evidence that tolerance develops to the sedative effects of benzodiazepines. Lorazepam should be used with caution in patients with compromised respiratory function e. COPD , sleep apnea syndrome. Elderly or debilitated patients may be more susceptible to the sedative effects of lorazepam. What form s does this medication come in? This medication does not contain gluten or tartrazine. Who should NOT take this medication?
Do not take lorazepam if you: Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. There have been cases of marked sedation when Ativan was given to patients taking the tranquilizer loxapine Loxitane ; it is unclear if there is a drug interaction, but caution should be used if Ativan and loxapine are used together.
Is Ativan lorazepam safe to use during pregnancy or while breastfeeding? Ativan and other benzodiazepines have been associated with fetal damage, including congenital malformations , when taken by pregnant women in their first trimester. Ativan is best avoided if at all possible in the first trimester and probably throughout pregnancy. Also, one must ascertain whether other substances were also ingested.
Signs of overdose range through mental confusion, dysarthria , paradoxical reactions , drowsiness , hypotonia , ataxia , hypotension , hypnotic state , coma , cardiovascular depression, respiratory depression , and death. Early management of alert patients includes emetics , gastric lavage , and activated charcoal.
Otherwise, management is by observation, including of vital signs, support and, only if necessary, considering the hazards of doing so, giving intravenous flumazenil. Patients are ideally nursed in a kind, frustrating environment, since, when given or taken in high doses, benzodiazepines are more likely to cause paradoxical reactions. If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues.
Detection in body fluids[ edit ] Lorazepam may be quantitated in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence of an impaired driving arrest or to assist in a medicolegal death investigation. This contrasts with the highly lipid-soluble diazepam , which, although rapidly absorbed orally or rectally, soon redistributes from the serum to other parts of the body, in particular, body fat.
This explains why one lorazepam dose, despite its shorter serum half-life, has more prolonged peak effects than an equivalent diazepam dose. Lorazepam glucuronide has no demonstrable CNS activity in animals.
The plasma levels of lorazepam are proportional to the dose given. There is no evidence of accumulation of lorazepam on administration up to six months. On regular administration, diazepam will accumulate, since it has a longer half-life and active metabolites, these metabolites also have long half-lives.
Diazepam has long been a drug of choice for status epilepticus ; its high lipid solubility means it gets absorbed with equal speed whether given orally, or rectally nonintravenous routes are convenient in outside hospital settings , but diazepam's high lipid solubility also means it does not remain in the vascular space, but soon redistributes into other body tissues. So, it may be necessary to repeat diazepam doses to maintain peak anticonvulsant effects, resulting in excess body accumulation.
Lorazepam is a different case; its low lipid solubility makes it relatively slowly absorbed by any route other than intravenously, but once injected, it will not get significantly redistributed beyond the vascular space. Therefore, lorazepam's anticonvulsant effects are more durable, thus reducing the need for repeated doses.
Although lorazepam is not necessarily better than diazepam at initially terminating seizures, [78] lorazepam is, nevertheless, replacing diazepam as the intravenous agent of choice in status epilepticus. Longer-term use, up to six months, does not result in further accumulation. Lorazepam is metabolized in the liver by conjugation into inactive lorazepam-glucuronide. This metabolism does not involve hepatic oxidation, so is relatively unaffected by reduced liver function.
Lorazepam-glucuronide is more water-soluble than its precursor, so gets more widely distributed in the body, leading to a longer half-life than lorazepam. Lorazepam-glucuronide is eventually excreted by the kidneys, [75] and, because of its tissue accumulation, it remains detectable, particularly in the urine, for substantially longer than lorazepam.
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