The manufacturer's leaflet will give you more information about the brand you have been given. It will also contain a full list of the side-effects which you may experience from taking promethazine. Take promethazine exactly as your doctor or pharmacist has told you to. You may be asked to take one or more doses during a day, depending upon the reason why you are taking it.
If you are taking promethazine to prevent travel sickness, it is usually recommended that you take the first dose at bedtime on the evening before you are due to travel.
You can then take a further dose on the morning of your travel if needed. You can take promethazine before or after meals. Some people find it helps to swallow the tablets with a drink of water.
If you are giving promethazine liquid medicine to a child, make sure you follow the dosing instructions on the bottle carefully so that you measure out the correct dose for the age of your child.
Most people only need to take an antihistamine for a short while when they have symptoms. You should stop taking promethazine once your symptoms have eased. Do not take promethazine for more than a few days for sleeping problems. Getting the most from your treatment Promethazine may cause drowsiness and blurred vision. If this happens to you, do not drive and do not use tools or machines. Alcohol will make the drowsiness worse, so it is best not to drink alcohol while you are on promethazine.
If you are having an operation or any treatment particularly if it is to test for an allergy , tell the person carrying out the treatment that you are taking promethazine. Do not increase your dose or take this medication more often than directed.
Tell your doctor if your condition does not improve or if it worsens. What conditions does Hydroxyzine Hcl treat? Side Effects Drowsiness, dizziness , blurred vision , constipation , or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To relieve dry mouth , suck sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: Get medical help right away if you have any very serious side effects, including: A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects.
If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at List Hydroxyzine Hcl side effects by likelihood and severity. When concurrent use cannot be avoided, monitor the patient for reduced donepezil efficacy. Moderate Concomitant use of dronabinol with promethazine can potentiate the effects of dronabinol on respiratory depression.
In addition, additive tachycardia and drowsiness may occur, which may be pronounced. Severe Dronedarone administration is associated with a dose-related increase in the QTc interval.
Although there are no studies examining the effects of dronedarone in patients receiving other QT prolonging drugs, coadministration of such drugs may result in additive QT prolongation.
The concomitant use of dronedarone with other drugs that prolong the QTc may induce Torsade de Pointes TdP and is contraindicated. Major Droperidol should be administered with extreme caution to patients receiving other agents that may prolong the QT interval. Droperidol administration is associated with an established risk for QT prolongation and torsades de pointes TdP.
In December , the FDA issued a black box warning regarding the use of droperidol and its association with QT prolongation and potential for cardiac arrhythmias based on post-marketing surveillance data. Any drug with known potential to prolong the QT interval should not be coadministered with droperidol.
Drugs with a potential risk for QT prolongation that should be used cautiously and with close monitoring with droperidol include promethazine. In addition, promethazine has sedating actions and may have additive or potentiating sedative and other CNS effects with droperidol. Moderate Use caution when administering tamsulosin with a moderate CYP2D6 inhibitor such as promethazine. Tamsulosin is extensively metabolized by CYP2D6 hepatic enzymes. In clinical evaluation, concomitant treatment with a strong CYP2D6 inhibitor resulted in increases in tamsulosin exposure; interactions with moderate CYP2D6 inhibitors have not been evaluated.
If concomitant use in necessary, monitor patient closely for increased side effects. Major Although data are limited, coadministration of efavirenz and promethazine may increase the risk for QT prolongation and torsade de pointes TdP. QT prolongation has also been observed with use of efavirenz. Major Coadministration of promethazine and eliglustat may result in increased concentrations of the phenothiazine and an increased risk of QT prolongation.
If coadministration is necessary, use great caution and monitor closely. Consider reducing the dosage of promethazine and titrating to clinical effect. Emtricitabine; Rilpivirine; Tenofovir alafenamide: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include rilpivirine.
Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include eribulin. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include erythromycin.
Moderate Escitalopram may cause dose-dependent QT interval prolongation. Use caution in combining escitalopram with other drugs that may cause QT prolongation.
Major Alcohol is associated with CNS depression. The combined use of alcohol and CNS depressants can lead to additive CNS depression, which could be dangerous in tasks requiring mental alertness and fatal in overdose. Alcohol taken with other CNS depressants can lead to additive respiratory depression, hypotension, profound sedation, or coma.
Consider the patient's use of alcohol or illicit drugs when prescribing CNS depressant medications. In many cases, the patient should receive a lower dose of the CNS depressant initially if the patient is not likely to be compliant with avoiding alcohol.
Moderate The combination of anticonvulsants e. The phenothiazines are known to lower seizure threshold, and this may be a particular risk for patients receiving anticonvulsants.
Additive CNS depression may also occur. Major Coadministration may result in additive effects on the QT interval. Both ezogabine and promethazine have been associated with QT prolongation.
In addition, ezogabine has caused urinary retention requiring catheterization in some cases. The anticholinergic effects of promethazine on the urinary tract may be additive. Additive sedation or other CNS effects may also occur. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include fingolimod. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include flecainide.
Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include fluconazole. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include fluoxetine. Moderate The use of promethazine, a phenothiazine antiemetic, with atypical antipsychotics such as olanzapine should be avoided when possible.
Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Promethazine has also been reported to cause QT prolongation.
Moderate The use of promethazine, a phenothiazine antiemetic, with phenothiazine antipsychotics such as fluphenazine should be avoided if possible. Co-administration of promethazine and antipsychotics may increase the risk of adverse effects such as drowsiness, dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures. In addition, promethazine is associated with QT prolongation and fluphenazine is associated with a possible risk of QT prolongation.
Concomitant administration would increase the risk of QT prolongation. Moderate There may be an increased risk for QT prolongation and torsade de pointes TdP during concurrent use of fluvoxamine and promethazine. QT prolongation and TdP have been reported during postmarketing use of fluvoxamine. Major It is recommended that patients avoid the use of marijuana, by any route, if they are treated for a psychiatric history, including psychosis and bipolar disorder, as the cannabinoids the psychoactive ingredients, such as THC in marijuana can produce psychotoxic effects and may exacerbate psychiatric disorders.
A high frequency of use and use of products with high-potency of THC are potential risk factors for psychiatric effects. Clinical studies suggest that cannabis use may reduce the efficacy of some antipsychotic drugs. In addition, several cannabinoids in marijuana appear to influence the activity of CYP enzymes and P-glycoprotein, which may alter the concentrations of antipsychotics and influence either safety or efficacy, For example, the smoking of marijuana influences the metabolism of some medications in a manner similar to tobacco by inducing CYP1A2.
Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as promethazine. Foscarnet has been associated with postmarketing reports of both QT prolongation and torsade de pointes TdP. If these drugs are administered together, obtain an electrocardiogram and electrolyte concentrations before and periodically during treatment.
Moderate Promethazine exhibits anticholinergic properties that could potentially interfere with the cholinesterase inhibitor activity of galantamine. When concurrent use cannot be avoided, monitor the patient for reduced galantamine efficacy.
Major Monitor for an increased incidence of gefitinib-related adverse effects if gefitinib and promethazine are used concomitantly. Coadministration may decrease the metabolism of gefitinib and increase gefitinib concentrations.
While the manufacturer has provided no guidance regarding the use of gefitinib with CYP2D6 inhibitors, in patients with poor CYP2D6 metabolism, the mean exposure to gefitinib was 2-fold higher when compared to extensive metabolizers; the contribution of drugs that inhibit CYP2D6 on gefitinib exposure has not been evaluated.
Additionally, at high concentrations, gefitinib is an inhibitor of CYP2D6, which is the primary isoenzyme responsible for the metabolism of promethazine.
Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include gemifloxacin. Moderate Use gemtuzumab ozogamicin and promethazine together with caution due to the potential for additive QT interval prolongation and risk of torsade de pointes TdP.
If these agents are used together, obtain an ECG and serum electrolytes prior to the start of gemtuzumab and as needed during treatment. Although QT interval prolongation has not been reported with gemtuzumab, it has been reported with other drugs that contain calicheamicin. Promethazine, a phenothiazine, is also associated with a possible risk for QT prolongation.
Moderate Androgen deprivation therapy e. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with goserelin include promethazine.
Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include granisetron. Moderate Halogenated anesthetics carry a possible risk for QT prolongation and torsade de pointes TdP.
Promethazine carries a possible risk of QT prolongation and should be used cautiously with these anesthetics, with proper blood pressure and heart rate monitoring. Due to the risk of additive QT prolongation and potential for serious arrhythmias, promethazine should be used with caution in patients receiving haloperidol.
In addition, co-administration of promethazine with haloperidol may increase the risk of adverse effects such as drowsiness, dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures.
Major Avoid coadministration of hydroxychloroquine and promethazine. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. Ventricular arrhythmias and torsade de pointes have been reported with the use of hydroxychloroquine. Promethazine is associated with a possible risk for QT prolongation.
Major Promethazine should be used cautiously and with close monitoring with hydroxyzine. In addition, additive anticholinergic effects may be seen when promethazine is used concomitantly with other drugs with antimuscarinic activity like sedating H1-blockers. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include ibutilide. Major Iloperidone has been associated with QT prolongation.
Due to the risk of additive QT prolongation and potential for serious arrhythmias, other drugs having an association with QT prolongation are best avoided with iloperidone. Minor It is unclear if phenothiazines directly interact with antidiabetic agents, phenothiazines have been reported to increase blood glucose concentrations.
Major Avoid coadministration of inotuzumab ozogamicin with promethazine due to the potential for additive QT prolongation and risk of torsade de pointes TdP. If coadministration is unavoidable, obtain an ECG and serum electrolytes prior to the start of treatment, after treatment initiation, and periodically during treatment. Inotuzumab has been associated with QT interval prolongation. Promethazine should be used cautiously in patients receiving antidiabetic agents; patients should routinely monitor their blood glucose as indicated.
Major Ipecac has been shown to be effective in producing emesis in patients who have ingested antiemetics, provided ipecac is given promptly usually within 1 hour of antiemetic consumption.
If ipecac is administered after antiemetic therapy has begun to exert therapeutic effects, ipecac may be less effective. It is suggested the irritating GI effects of ipecac lead to emesis following antiemetic consumption.
Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include itraconazole. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include ketoconazole.
Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include lapatinib.
Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include lenvatinib. Moderate Androgen-deprivation therapy e. Promethazine a phenothiazine antiemetic and antihistamine carries a possible risk of QT prolongation. Drugs with a possible risk for QT prolongation and TdP should be used cautiously together.
Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include levofloxacin. Major Amphetamines may pharmacodynamically counteract the sedative properties of some antihistamines. Moderate Lithium should be used cautiously and with close monitoring with promethazine. Both lithium and promethazine have been associated with QT prolongation.
Because lithium has the potential to impair cognitive and motor skills, caution is advisable during concurrent use of other medications with centrally-acting effects including antihistamines such as promethazine. Use cautiously with promethazine, which has been reported to cause QT prolongation. Moderate Coadministration of loperamide with promethazine may increase the risk for QT prolongation and torsade de pointes TdP. Promethazine is associated with a possible risk for QT prolongation and high doses of loperamide have been associated with serious cardiac toxicities, including syncope, ventricular tachycardia, QT prolongation, torsade de pointes TdP , and cardiac arrest.
In addition, the plasma concentrations of loperamide, a CYP2D6 substrate, may be increased when administered concurrently with promethazine, a potent CYP2D6 inhibitor, further increasing the risk of toxicity. If these drugs are used together, monitor for cardiac toxicities i. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include lopinavir; ritonavir. Moderate The use of promethazine, a phenothiazine antiemetic, with antipsychotics such as loxapine should be avoided if possible.
Co-administration of promethazine with loxapine may increase the risk of adverse effects such as drowsiness, dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures. The likelihood of these pharmacodynamic interactions varies based upon the individual properties of the co-administered antipsychotic agent.
Moderate The use of promethazine, a phenothiazine, with antipsychotics such as lurasidone should be avoided if possible. Co-administration of promethazine with lurasidone may increase the risk of adverse effects such as drowsiness, dizziness, orthostatic hypotension, anticholinergic effects, extrapyramidal symptoms, neuroleptic malignant syndrome, or seizures.
Moderate Promethazine carries a risk of QT prolongation and should be used cautiously with drugs that may prolong the QT interval and have additive anticholinergic properties such as maprotiline. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with promethazine include mefloquine. Major The need to coadminister methadone with drugs known to prolong the QT interval should be done with extreme caution and a careful assessment of treatment risks versus benefits.
Drugs with a potential risk for QT prolongation that should be used cautiously with methadone include promethazine. Additionally, use of methadone with another CNS depressant can lead to additive sedation, respiratory depression, hypotension, or coma. Because promethazine causes pronounced sedation, an enhanced CNS depressant effect or additive drowsiness may occur when it is combined with other CNS depressants.
Prior to concurrent use of methadone in patients taking a CNS depressant, assess the level of tolerance to CNS depression that has developed, the duration of use, and the patient's overall response to treatment.
Consider the patient's use of alcohol or illicit drugs. Methadone should be used with caution and in reduced dosages if used concurrently with a CNS depressant; for example, in opioid-naive adults, use an initial methadone dose of 2. Also consider a using a lower dose of the CNS depressant.
Monitor patients for sedation and respiratory depression. Major Amphetamines may counteract the sedative properties of promethazine. Combination therapy can cause additive effects of sedation and dizziness, which can impair the patient's ability to undertake tasks requiring mental alertness. Dosage adjustments of either or both medications may be necessary. Moderate Phenothiazines may increase the photosensitizing effects of photosensitizing agents used in photodynamic therapy.
Patients should limit ultra-violet UV exposure. Severe Metoclopramide is a central dopamine antagonist and may cause extrapyramidal reactions e. Metoclopramide is contraindicated with other drugs that are likely to cause extrapyramidal effects since the risk of these effects may be increased. Since recurrences of NMS have been reported with phenothiazines, the reintroduction of promethazine HCl promethazine hydrochloride should be carefully considered.
Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine in pediatric patients. In pediatric patients who are acutely ill associated with dehydration , there is an increased susceptibility to dystonias with the use of promethazine HCl promethazine hydrochloride. Other Considerations Administration of promethazine HCl promethazine hydrochloride has been associated with reported cholestatic jaundice. Promethazine hydrochloride tablets should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
Carcinogenesis, mutagenesis, impairment of fertility Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity or impairment of fertility with this drug. Promethazine was nonmutagenic in the Salmonella test system of Ames.
Pregnancy Teratogenic Effects-Pregnancy Category C Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.
These doses are from approximately 2.
Active and prophylactic treatment of motion sickness. Promethazine is well absorbed from the gastrointestinal tract. Promethazine for occurs as a white to faint yellow, practically odorless, promethazine hydrochloride 25mg for insomnia, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. If you 25mg, quickly look for a place to cool down and rest. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs hydrochloride, nonprescription drugs, and herbal products. It allows the neurotransmitter called histamine to build up in the spaces called synapses that are present between nerve cells. Discuss the risks and benefits with your doctor. The amount you need to take depends on the zolpidem ratiopharm 10mg you are taking Phenergan Tablets. We disqualified the ones with unnecessary, synthetic fillers and those whose contents differed drastically from pill to pill. Additionally, caution should be used insomnia this medication is used by children younger than six years old and by the elderly. Promethazine, they include many irrelevant extras and synthetic fillers. Do not use a household spoon because you may not get the correct dose. What should I know regarding pregnancy, nursing and administering Promethazine HCL to children or the elderly?
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