Zyprexa 10mg injection

Do not freeze after reconstitution. Discard any unused contents. Each vial contains 10 mg of the active substance.

Your doctor or nurse will make it up into a solution that will be given as an injection. Not all pack sizes may be marketed. Further dosage adjustments, if indicated, should generally occur at intervals of not less than 1 week, since steady state for olanzapine would not be achieved for approximately 1 week in the typical patient. Dosing in Special Populations — The recommended starting dose is 5 mg in patients who are debilitated, who have a predisposition to hypotensive reactions, who otherwise exhibit a combination of factors that may result in slower metabolism of olanzapine e.

When indicated, dose escalation should be performed with caution in these patients. The physician who elects to use ZYPREXA for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient.

Adolescents Dose Selection — Oral olanzapine should be administered on a once-a-day schedule without regard to meals with a recommended starting dose of 2. The recommended starting dose of Zyprexa tablets depends on the disease being treated: The dose is adjusted according to how well the patient responds to and tolerates the treatment. The usual dose range is between 5 and 20 mg per day. The usual dose when using the injection is 10 mg as a single injection into a muscle. This can be followed if needed by a further injection of 5 or 10 mg two hours later.

Lower doses may be needed for patients over 65 years of age 5 mg per day for the tablets and 2. In all cases, the maximum dose of Zyprexa that can be given in a day, using tablets or injection, is 20 mg. If you have a history of blood problems or are on other drugs that can lower levels of these blood cells, your doctor should check your blood often during the first few months of treatment with this drug. They should also monitor you for fever or any signs of infection.

Your doctor might have to stop your treatment with olanzapine until your blood cell levels return to normal. People with liver problems If you have liver problems or a history of liver disease, you may not be able to clear this drug from your body well.

This may increase the levels of olanzapine in your body and cause more side effects. This drug can also damage your liver. People with enlarged prostate In men, olanzapine may worsen symptoms of an enlarged prostate or benign prostatic hyperplasia BPH. If you have an enlarged prostate, talk with your doctor about whether this drug is safe for you.

People with narrow-angle glaucoma Olanzapine may worsen your glaucoma symptoms. People with bowel problems Olanzapine may worsen any bowel obstruction or blockages. If you have any bowel problems, talk with your doctor about whether this drug is safe for you. Pregnant women Olanzapine is a category C pregnancy drug.

That means two things: Research in animals has shown adverse effects to the fetus when the mother takes the drug. For females, this rare increase in prolactin levels may result in unwanted breast milk, the menstrual period stopping, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm , or enlarged breasts.

If you develop any of these symptoms, tell your doctor right away. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects.

You may report side effects to Health Canada at List Zyprexa Vial side effects by likelihood and severity. Precautions Before using olanzapine , tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Nonspecific lymphopenia, consistent with decreased body weight gain, occurred in rats receiving No evidence of bone marrow cytotoxicity was found in any of the species examined.

Bone marrows were normocellular or hypercellular, indicating that the reductions in circulating blood cells were probably due to peripheral non-marrow factors. Patients enrolled in the trials needed to be: The primary efficacy measure used for assessing agitation signs and symptoms in these trials was the change from baseline in the PANSS Excited Component at 2 hours post-injection.

Patients could receive up to 3 injections during the 24 hour intramuscular treatment periods; however, patients could not receive the second injection until after the initial 2 hour period when the primary efficacy measure was assessed.

The results of the trials follow: However, the effect was larger and more consistent for the 3 highest doses. There were no significant pairwise differences for the 7. Examination of population subsets age, race, and gender did not reveal any differential responsiveness on the basis of these subgroupings.

Discard any unused portion of reconstituted olanzapine for injection. Protect olanzapine for injection from light, do not freeze. If you do not think you are getting better or have any concerns about your condition while taking olanzapine, call your doctor. Increased Mortality and Cerebrovascular Adverse Events CVAE , Including Stroke Patients and caregivers should be advised that elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

Patients and caregivers should be advised that elderly patients with dementia-related psychosis treated with olanzapine had a significantly higher incidence of cerebrovascular adverse events e. Olanzapine is not approved for elderly patients with dementia-related psychosis [see Boxed Warning and Warnings and Precautions 5. Signs and symptoms of NMS include hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia [see Warnings and Precautions 5.

Patients should be monitored regularly for worsening of glucose control. Patients who have diabetes should follow their doctor's instructions about how often to check their blood sugar while taking olanzapine [see Warnings and Precautions 5. Patients should have their lipid profile monitored regularly [see Warnings and Precautions 5. Patients should have their weight monitored regularly [see Warnings and Precautions 5.

Patients should be advised to change positions carefully to help prevent orthostatic hypotension, and to lie down if they feel dizzy or faint, until they feel better.

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