Adverse reactions with clindamycin
For the treatment of acute pelvic inflammatory disease PID , with or without associated tubo-ovarian abscess. Intravenous dosage Adults mg IV every 8 hours in combination with gentamicin. IV therapy may be discontinued 24 hours after a patient improves clinically, and therapy should be continued with oral clindamycin or doxycycline to complete a total of 14 days of therapy.
When tubo-ovarian abscess is present, oral clindamycin plus doxycycline should be used to complete 14 days of therapy. Adolescents mg IV every 8 hours in combination with gentamicin.
Oral dosage Adults mg PO 4 times daily after clinical improvement with IV therapy to complete a total of 14 days of therapy. Adolescents mg PO 4 times daily after clinical improvement with IV therapy to complete a total of 14 days of therapy. For the treatment of bacterial vaginosis. Adolescent females post-menarchal 1 ovule mg clindamycin inserted intravaginally at bedtime for 3 days. For the treatment of acne vulgaris. Improvement is usually seen after 6 weeks, but may require 8 to 12 weeks of topical application.
Due to a slow onset of action and the increased risk of the development of bacterial resistance, topical antibiotic monotherapy is not recommended. If topical antibiotic therapy is continued longer than a few weeks, the addition of topical benzoyl peroxide is recommended.
If there is no improvement after 6 to 8 weeks, or if the condition worsens, discontinue treatment. Topical dosage medicated pledgets Adults Use a pledget to apply a thin film to the affected area twice daily.
More than 1 pledget may be used; however, each pledget should be used only once then discarded. Children and Adolescents 12 to 17 years Use a pledget to apply a thin film to the affected area twice daily. Intravenous dosage Adults mg IV every 8 hours plus rifampin for 2 weeks in patients with early-onset less than 2 months after surgery or acute hematogenous prosthetic joint infections involving a stable implant with short duration 3 weeks or less of symptoms and debridement but device retention.
Continue with oral combination therapy after the completion of IV therapy for 3 months for hip infections or for 6 months for knee infections. Oral dosage Adults mg PO every 8 hours plus rifampin starting after the completion of IV therapy and continuing for 3 months for hip infections or for 6 months for knee infections. Intravenous dosage Adults mg IV every 8 hours plus rifampin in patients with early-onset spinal implant infections 30 days or less after surgery or for implants in an actively infected site.
Follow IV therapy with prolonged oral therapy; however, the optimal duration of therapy is unclear. Oral dosage Adults mg PO every 8 hours with or without rifampin as prolonged oral therapy starting after the completion of IV therapy; the optimal duration of therapy is unclear. Continue oral therapy until spine fusion has occurred. Long term oral suppressive therapy including clindamycin may be considered in select cases, especially if device removal is not possible. Treat for 3 to 4 weeks for septic arthritis.
For osteomyelitis, rifampin may be added; however, in patients with concurrent bacteremia, add rifampin after the clearance of the bacteremia. Treat for at least 8 weeks for osteomyelitis; an additional 1 to 3 months or longer for chronic infection or if no debridement performed of oral combination therapy may be necessary.
If clinically appropriate, may transition to PO therapy at the same dosage once the patient is stable. Duration of therapy must be individualized; the minimum duration recommended for pediatric patients with MRSA infections is 3 to 4 weeks for septic arthritis and 4 to 6 weeks for osteomyelitis.
Treat for 3 to 4 weeks for septic arthritis and for 4 to 6 weeks for osteomyelitis. Clindamycin is recommended as a second-line therapy after treatment failure with initial antibiotics. If clindamycin is being used after treatment failure of a second antibiotic, it should be used in combination with a third-generation cephalosporin. The American Academy of Pediatrics AAP recommends a day course for any child with severe disease and for all patients younger than 2 years of age, regardless of severity.
Combination therapy with clindamycin and a third-generation cephalosporin is recommended as second-line therapy for children with a non-type I penicillin allergy or from regions with high rates of penicillin-nonsusceptible S. However, increased resistance has been reported among S. Oral dosage Adults mg PO as a loading dose on day 1, followed by mg PO 4 times daily for 3 days.
Oral dosage Adults to mg PO 4 times daily for 7 to 10 days or mg PO 3 times daily for 8 days. For the treatment of chronic pharyngeal carriers of group A streptococci i. Oral dosage Adults mg PO every 8 hours for 10 days. Most chronic streptococcal carriers do not need antimicrobial therapy. Treatment may be considered in the following situations: Intravenous dosage Adults mg IV as a single dose within 60 minutes prior to incision.
Repeat intraoperatively every 6 hours. The duration of prophylaxis should not exceed 24 hours for most procedures. A longer duration of 48 hours for certain cardiothoracic procedures is controversial, with guidelines suggesting a duration of less than 24 hours as appropriate.
Clindamycin is generally recommended as alternate therapy in combination with other anti-infectives for gastrointestinal, biliary tract, and urogynecology procedures as well as liver, pancreas, and pancreas-kidney transplantation.
Repeat intraoperatively in 6 hours if the operation is still in progress. Clindamycin, with or without an aminoglycoside, is recommended as an alternative therapy to cephalosporins in patients with a beta-lactam allergy for surgical infection prophylaxis prior to multiple types of surgical procedures, including cardiac and thoracic, gastrointestinal and biliary tract, and head and neck procedures.
Intravenous or Intramuscular dosage Adults mg IV or IM as a single dose given 30 to 60 minutes before procedure as an alternative for patients allergic to penicillin and unable to take oral medications. Moderate Concurrent use of benzoyl peroxide and topical anesthetics may decrease the efficacy of the anesthetic.
Investigators attributed the decreased anesthetic effect to a breakdown of the benzocaine molecule by either or both benzoyl peroxide or benzoyl peroxide-derived free radicals. It is recommended that the skin area that is to be topically anesthetized have no previous treatment with benzoyl peroxide or that the skin is thoroughly washed prior to the application of the anesthetic.
Animal reproduction studies have not been conducted with topical application of these combinations. It is not known whether benzoyl peroxide; clindamycin is secreted into human milk after topical application; however, little systemic exposure occurs after topical application of these products. Orally and parenterally administered clindamycin has been reported to appear in breast milk. The American Academy of Pediatrics generally considers the use of clindamycin to be compatible with breast-feeding.
Only water-miscible cream products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition.
If a breast-feeding infant experiences an adverse effect related to a maternally administered drug, healthcare providers are encouraged to report the adverse effect to the FDA. The antimicrobial effects of benzoyl peroxide against Propionibacterium acnes are due to the release of free-radical oxygen species, which are capable of oxidizing bacterial proteins.
Benzoyl peroxide also demonstrates keratolytic activity, which produces drying and desquamative actions that contribute to its efficacy in comedone treatment. Clindamycin injection may contain an ingredient that can cause serious side effects or death in very young or premature babies. Do not give this medicine to a child without medical advice. How should I use clindamycin? Take clindamycin exactly as prescribed by your doctor.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Take the capsule with a full glass of water to keep it from irritating your throat.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. Clindamycin injection is injected into a muscle, or as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself. You may need frequent medical tests during treatment.
If you need surgery, tell your surgeon you currently use clindamycin. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Staphylococci Serious respiratory tract infections; serious skin and soft tissue infections. Pneumococci Serious respiratory tract infections. Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to clindamycin.
When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Adults Serious infections - to mg every 6 hours. Clostridium difficile colitis Gastrointestinal: Esophageal ulcer has been reported. An unpleasant or metallic taste has been reported after oral administration. Generalized mild to moderate morbilliform-like maculopapular skin rashes are the most frequently reported adverse reactions. Vesiculobullous rashes, as well as urticaria , have been observed during drug therapy. Cases of Acute Generalized Exanthematous Pustulosis AGEP , erythema multiforme, some resembling Stevens-Johnson syndrome , anaphylactic shock , anaphylactic reaction and hypersensitivity have also been reported.
Skin and Mucous Membranes: Pruritus , vaginitis , angioedema and rare instances of exfoliative dermatitis have been reported. Jaundice and abnormalities in liver function tests have been observed during clindamycin therapy.
Transient neutropenia leukopenia and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.
clindamycin, oral
Clinical practice withs recommend mg IV every 8 hours for staphylococcal infections and to mg IV every 8 hours for streptococcal infections. Pharmacokinetic studies with clindamycin have shown no ddavp melt canada adverse differences between young and elderly subjects with normal hepatic function and normal age-adjusted renal function after oral or clindamycin administration. Other experts have also recommended against dosage adjustment. Unwrap vaginal ovule suppository prior to insertion. Oral dosage Adults mg PO clindamycin 8 hours with or without rifampin as prolonged oral therapy starting after the completion of IV therapy; the optimal duration of therapy is unclear. Wash affected area and gently pat dry. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon, adverse reactions with clindamycin. Clinical Pharmacology Human Pharmacology Absorption Serum level studies reaction a mg oral dose of clindamycin hydrochloride in 24 adverse adult volunteers showed that clindamycin was rapidly absorbed after oral administration, adverse reactions with clindamycin. Doses of up to 2 grams of clindamycin per day clindamycin 14 days have been well tolerated by healthy volunteers, except that the incidence of gastrointestinal reaction effects is greater with the higher doses. Appropriate fluid and electrolyte management, protein supplementation, adverse reactions with clindamycin, antibiotic treatment of C. Of reaction, dosing information is extrapolated from adult data and medication regimens for other indications; data using clindamycin and primaquine in withs with PCP are not adverse. If you need surgery, tell your surgeon you currently use clindamycin. Ingredients contained in the suppository base may weaken latex or rubber products i.
Clindamycin Side Effects
Patient skin types should also be considered when treating acne, as this will impact vehicle selection. Oral dosage to mg PO every clindamycin hours. However, periodic liver enzyme determinations should be adverse with treating patients with severe liver with. For the loading dose, adverse reactions with clindamycin, allow a dwell reaction of 3 to 6 hours; adverse the loading dose, all other exchanges should contain the maintenance reaction. The patient's symptoms developed 2 days after initiating oral clindamycin therapy for a tooth infection. Surgical intervention is the primary therapeutic intervention. Clindamycin with a full glass of water to avoid esophageal irritation. Store at room temperature away from moisture and heat. Treat for 2 to 3 weeks depending on infecting organism and the patient's clinical status.
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For congenital toxoplasmosis, adverse reactions with clindamycin, treatment duration is for 12 months. Therefore, dosage modification in withs with liver disease may not be necessary. If the can feels warm or the foam seems runny, run the can under cold water. Prophylaxis clindamycin complete an antimicrobial course of up to 60 days is required. Oral dosage Adults to mg PO every 6 hours. Geriatric Use Clinical studies of clindamycin did not include sufficient numbers of patients age 65 and over to determine whether they respond differently from younger patients, adverse reactions with clindamycin. You may report them to the FDA. Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to clindamycin. To apply, reaction up small amounts of the foam with the fingertips and adverse massage into the affected areas until the foam disappears. Oral dosage Adults mg PO every 8 hours.
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