Brand names oxycodone acetaminophen

This should be considered when prescribing or dispensing PERCOCET tablets in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion. Concerns about misuse, addiction, and diversion should not prevent the proper management of pain. Healthcare professionals should contact their State Professional Licensing Board or State Controlled Substances Authority for information on how to prevent and detect abuse or diversion of this product.

Elderly and debilitated patients are at particular risk for respiratory depression as are non-tolerant patients given large initial doses of oxycodone or when oxycodone is given in conjunction with other agents that depress respiration. Oxycodone should be used with extreme caution in patients with acute asthma, chronic obstructive pulmonary disorder COPD , cor pulmonale , or preexisting respiratory impairment.

In such patients, even usual therapeutic doses of oxycodone may decrease respiratory drive to the point of apnea. In these patients alternative non-opioid analgesics should be considered, and opioids should be employed only under careful medical supervision at the lowest effective dose.

Head Injury and Increased Intracranial Pressure The respiratory depressant effects of opioids include carbon dioxide retention and secondary elevation of cerebrospinal fluid pressure, and may be markedly exaggerated in the presence of head injury , other intracranial lesions or a pre-existing increase in intracranial pressure.

Oxycodone produces effects on pupillary response and consciousness which may obscure neurologic signs of worsening in patients with head injuries. Hypotensive Effect Oxycodone may cause severe hypotension particularly in individuals whose ability to maintain blood pressure has been compromised by a depleted blood volume, or after concurrent administration with drugs which compromise vasomotor tone such as phenothiazines.

Oxycodone, like all opioid analgesics of the morphine-type, should be administered with caution to patients in circulatory shock, since vasodilation produced by the drug may further reduce cardiac output and blood pressure. Oxycodone may produce orthostatic hypotension in ambulatory patients.

Hepatotoxicity Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed milligrams per day, and often involve more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products.

The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking acetaminophen. Instruct patients to look for acetaminophen or APAP on package labels and not to use more than one product that contains acetaminophen. Instruct patients to seek medical attention immediately upon ingestion of more than milligrams of acetaminophen per day, even if they feel well.

Patients should be informed about the signs of serious skin reactions, and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity. Clinical signs including swelling of the face, mouth, and throat, respiratory distress, urticaria , rash, pruritus , and vomiting. There were infrequent reports of life-threatening anaphylaxis requiring emergency medical attention.

PERCOCET tablets should be given with caution to patients with CNS depression, elderly or debilitated patients, patients with severe impairment of hepatic, pulmonary, or renal function, hypothyroidism , Addison's disease, prostatic hypertrophy , urethral stricture, acute alcoholism, delirium tremens , kyphoscoliosis with respiratory depression, myxedema, and toxic psychosis. Oxycodone may aggravate convulsions in patients with convulsive disorders, and all opioids may induce or aggravate seizures in some clinical settings.

Following administration of PERCOCET tablets, anaphylactic reactions have been reported in patients with a known hypersensitivity to codeine, a compound with a structure similar to morphine and oxycodone. The frequency of this possible cross-sensitivity is unknown.

Ambulatory Surgery and Postoperative Use Oxycodone and other morphine-like opioids have been shown to decrease bowel motility. Ileus is a common postoperative complication, especially after intra-abdominal surgery with use of opioid analgesia. Caution should be taken to monitor for decreased bowel motility in postoperative patients receiving opioids.

Standard supportive therapy should be implemented. Opioids like oxycodone may cause increases in the serum amylase level. Tolerance and Physical Dependence Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia in the absence of disease progression or other external factors.

Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and tolerance are not unusual during chronic opioid therapy. The opioid abstinence or withdrawal syndrome is characterized by some or all of the following: Other symptoms also may develop, including: Laboratory Tests Although oxycodone may cross-react with some drug urine tests, no available studies were found which determined the duration of detectability of oxycodone in urine drug screens.

However, based on pharmacokinetic data, the approximate duration of detectability for a single dose of oxycodone is roughly estimated to be one to two days following drug exposure.

Urine testing for opiates may be performed to determine illicit drug use and for medical reasons such as evaluation of patients with altered states of consciousness or monitoring efficacy of drug rehabilitation efforts. The preliminary identification of opiates in urine involves the use of an immunoassay screening and thin-layer chromatography TLC.

The identities of 6-keto opiates e. Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenesis Animal studies to evaluate the carcinogenic potential of oxycodone and acetaminophen have not been performed.

Mutagenesis The combination of oxycodone and acetaminophen has not been evaluated for mutagenicity. Oxycodone alone was negative in a bacterial reverse mutation assay Ames , an in vitro chromosome aberration assay with human lymphocytes without metabolic activation and an in vivo mouse micronucleus assay. Oxycodone was clastogenic in the human lymphocyte chromosomal assay in the presence of metabolic activation and in the mouse lymphoma assay with or without metabolic activation.

Fertility Animal studies to evaluate the effects of oxycodone on fertility have not been performed. PERCOCET should not be given to a pregnant woman unless in the judgment of the physician, the potential benefits outweigh the possible hazards.

Nonteratogenic Effects Opioids can cross the placental barrier and have the potential to cause neonatal respiratory depression. Opioid use during pregnancy may result in a physically drug-dependent fetus. After birth, the neonate may suffer severe withdrawal symptoms. Speak with an Intake Coordination Specialist now. One of the primary risks is an addiction. Addiction refers to a disease of the brain. With opioids including oxycodone, what happens is that you take it and you may feel a euphoric rush, particularly if you take a stronger dose.

Your brain floods your system with dopamine which is a feel-good chemical because of the drug, and then your brain wants to keep that feeling going. Your brain is wired to repeat pleasurable things. This is why oxycodone is Schedule II. According to the DEA, this means that it does have medical uses in the U. Physical dependence is separate from addiction, and it can occur with or without a psychological addiction to the drug.

Physical dependence means your body has become dependent on the use of a drug, which in this case would be oxycodone. When that happens, and you try to stop using it suddenly, you may have withdrawal symptoms. Do not take with other acetaminophen medicines. This pain reliever has two active ingredients: Too much acetaminophen can damage the liver and cause death.

While taking oxycodone with acetaminophen, do not take nonprescription acetaminophen or other medicines that contain acetaminophen, including many cold medicines. Adults should not take more than 3, to 4, mg of acetaminophen each day.

Depending on what your doctor prescribed, each tablet or liquid dose of this medicine contains between mg and mg of acetaminophen.

Let your doctor and pharmacist know about all the prescription and nonprescription medicines you are taking, so other medicines that contain acetaminophen can be identified. Always read the active ingredients on medicine labels under Drug Facts on nonprescription medicine labels to avoid taking other medicines that contain acetaminophen. You may feel sleepy while taking this medicine. Avoid tasks that require mental alertness, such as driving or operating machinery.

Avoid drinking alcohol while taking this medicine. Prevent and treat constipation. Constipation is a common side effect when taking this medicine for more than a few days.

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