While taking the extended-release form of this medicine, part of the tablet may pass into your stools. This is normal and is nothing to worry about. Measure the oral liquid with a marked measuring spoon, syringe, or cup. The average household teaspoon may not hold the right amount of liquid.

Shake the bottle of medicine well just before taking each dose. If you are taking clarithromycin and zidovudine, these medicines should be taken at least 2 hours apart. Keep using the medicine for the full time of treatment, even if you or your child begin to feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. Dosing The dose of this medicine will be different for different patients. Caution should be exercised when prescribing clarithromycin with statins.

This may result in sub-therapeutic levels of clarithromycin leading to reduced efficacy. Furthermore, it might be necessary to monitor the plasma levels of the CYP3A inducer, which could be increased owing to the inhibition of CYP3A by clarithromycin see also the relevant product information for the CYP3A4 inhibitor administered. Concomitant administration of rifabutin and clarithromycin resulted in an increase in rifabutin, and decrease in clarithromycin serum levels together with an increased risk of uveitis.

The following drugs are known or suspected to affect circulating concentrations of clarithromycin; clarithromycin dosage adjustment or consideration of alternative treatments may be required.

Efavirenz, nevirapine, rifampicin, rifabutin and rifapentine Strong inducers of the cytochrome P metabolism system such as efavirenz, nevirapine, rifampicin, rifabutin, and rifapentine may accelerate the metabolism of clarithromycin and thus lower the plasma levels of clarithromycin, while increasing those of OH-clarithromycin, a metabolite that is also microbiologically active.

Since the microbiological activities of clarithromycin and OH-clarithromycin are different for different bacteria, the intended therapeutic effect could be impaired during concomitant administration of clarithromycin and enzyme inducers. Etravirine Clarithromycin exposure was decreased by etravirine; however, concentrations of the active metabolite, OHclarithromycin, were increased. Because OH-clarithromycin has reduced activity against Mycobacterium avium complex MAC , overall activity against this pathogen may be altered; therefore alternatives to clarithromycin should be considered for the treatment of MAC.

Steady state concentrations of the active metabolite OH-clarithromycin were not significantly affected by concomitant administration of fluconazole. No clarithromycin dose adjustment is necessary.

Ritonavir A pharmacokinetic study demonstrated that the concomitant administration of ritonavir mg every eight hours and clarithromycin mg every 12 hours resulted in a marked inhibition of the metabolism of clarithromycin. An essentially complete inhibition of the formation of OH-clarithromycin was noted. Because of the large therapeutic window for clarithromycin, no dosage reduction should be necessary in patients with normal renal function. However, for patients with renal impairment, the following dosage adjustments should be considered: Similar dose adjustments should be considered in patients with reduced renal function when ritonavir is used as a pharmacokinetic enhancer with other HIV protease inhibitors including atazanavir and saquinavir see section below, Bi-directional drug interactions Effect of Clarithromycin on Other Medicinal Products CYP3A-based interactions Co-administration of clarithromycin, known to inhibit CYP3A, and a drug primarily metabolised by CYP3A may be associated with elevations in drug concentrations that could increase or prolong both therapeutic and adverse effects of the concomitant drug.

Clarithromycin should be used with caution in patients receiving treatment with other drugs known to be CYP3A enzyme substrates, especially if the CYP3A substrate has a narrow safety margin e. Dosage adjustments may be considered, and when possible, serum concentrations of drugs primarily metabolised by CYP3A should be monitored closely in patients concurrently receiving clarithromycin. The following drugs or drug classes are known or suspected to be metabolised by the same CYP3A isozyme: Drugs interacting by similar mechanisms through other isozymes within the cytochrome P system include phenytoin, theophylline and valproate.

Antiarrhythmics There have been post-marketed reports of torsade de points occurring with the concurrent use of clarithromycin and quinidine or disopyramide. Electrocardiograms should be monitored for QTc prolongation during co-administration of clarithromycin with these drugs. Serum levels of quinidine and disopyramide should be monitored during clarithromycin therapy.

There have been post marketing reports of hypoglycemia with the concomitant administration of clarithromycin and disopyramide. Therefore blood glucose levels should be monitored during concomitant administration of clarithromycin and disopyramide. Careful monitoring of glucose is recommended. Omeprazole Clarithromycin mg every 8 hours was given in combination with omeprazole 40 mg daily to healthy adult subjects. The mean hour gastric pH value was 5.

Sildenafil, tadalafil and vardenafil Each of these phosphodiesterase inhibitors is metabolised, at least in part, by CYP3A, and CYP3A may be inhibited by concomitantly administered clarithromycin. Co-administration of clarithromycin with sildenafil, tadalafil or vardenafil would likely result in increased phosphodiesterase inhibitor exposure.

Reduction of sildenafil, tadalafil and vardenafil dosages should be considered when these drugs are co-administered with clarithromycin.

Dose reduction may need to be considered. In this population subset, inhibition of CYP3A results in significantly higher serum concentrations of tolterodine. A reduction in tolterodine dosage may be necessary in the presence of CYP3A inhibitors, such as clarithromycin in the CYP2D6 poor metaboliser population. If intravenous midazolam is co-administered with clarithromycin, the patient must be closely monitored to allow dose adjustment.

Drug delivery of midazolam via oromucosal route, which could bypass pre-systemic elimination of the drug, will likely result in a similar interaction to that observed after intravenous midazolam rather than oral administration.

Use of a statin that is not dependent on CYP3A metabolism e. It is recommended to prescribe the lowest registered dose if concomitant use cannot be avoided. With certain hypoglycemic drugs such as nateglinide, pioglitazone, repaglinide and rosiglitazone, inhibition of CYP3A enzyme by clarithromycin may be involved and could cause hypoglycemia when used concomitantly.

Careful monitoring of glucose is recommended [see Drug Interactions 7 ]. Use quetiapine and clarithromycin concomitantly with caution. Co-administration could result in increased quetiapine exposure and quetiapine related toxicities such as somnolence, orthostatic hypotension, altered state of consciousness, neuroleptic malignant syndrome, and QT prolongation.

Refer to quetiapine prescribing information for recommendations on dose reduction if co-administered with CYP3A4 inhibitors such as clarithromycin [see Drug Interactions 7 ]. There is a risk of serious hemorrhage and significant elevations in INR and prothrombin time when clarithromycin is co-administered with warfarin.

This condition may cause fast, chaotic heartbeats. Almost all antibiotics, including clarithromycin, can cause Clostridium difficile-associated diarrhea. This disease may range from causing mild diarrhea to severe inflammation of your colon. This can be fatal cause death. Call your doctor if you have diarrhea during or after treatment with this drug. For 1 to 10 years after taking this drug, people with coronary artery disease may be at increased risk of death for any reason.

The benefits of this drug should be weighed against this risk. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. Clarithromycin oral tablet comes in an immediate-release release form and an extended-release form.

Clarithromycin also comes as an oral suspension. Why it's used Clarithromycin is used to prevent and treat certain infections caused by bacteria. Clarithromycin may be used with other drugs ethambutol, rifampin, amoxicillin, lansoprazole, omeprazole, or bismuth to treat stomach ulcers or mycobacterial infections.

How it works Clarithromycin belongs to a class of drugs called antibiotics macrolides. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Clarithromycin works by stopping the bacteria that are causing an infection from multiplying. This drug should only be used to treat or prevent bacterial infections. Clarithromycin may interact with other medications Clarithromycin oral tablet can interact with other medications, vitamins, or herbs you may be taking.

An interaction is when a substance changes the way a drug works. Grapefruit juice should be avoided when taking this medication. When Is Clarithromycin Used? This medication is commonly used to treat the following: Lung infection pneumonia in patients from the age 5 to 15 years old Whooping cough Stomach ulcers caused by H.

How Should I Use Clarithromycin?

Clarithromycin 500mg Tablets

Allergy warning Clarithromycin can cause a severe allergic reaction. This condition may cause fast, chaotic heartbeats. If clarithromycin tablets clarithromycin used during pregnancy, clarithromycin 1000 mg daily, or if pregnancy occurs while the patient is taking this drug, the patient should be apprised of the potential hazard to the fetus. Concomitant administration of clarithromycin and oral midazolam is contraindicated see section 4. If you are using the extended-release tablets: Taking this drug with clarithromycin may result in serious, abnormal heart rhythms. This can be harmful or prevent the drug from working well. Adult only formulations, e. Treatment with antibacterial agents alters the normal flora of the colon, which may lead to 1000 of C. It is recommended to prescribe the lowest registered dose if concomitant use cannot be avoided. Pediatric Patients For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7. Plasma concentrations of clarithromycin as well as calcium channel blockers may increase due to the interaction. The cause of the increased risk has not been established. Codeine 3 2064 v, bradyarrhythmias and daily acidosis have been observed in patients taking clarithromycin and verapamil concomitantly. These include colchicine toxicity with colchicine; rhabdomyolysis with simvastatin, lovastatin, and atorvastatin; hypoglycemia with disopyramide; hypotension and acute kidney injury with calcium channel blockers metabolized by CYP3A4 e. In view of the emerging resistance of Streptococcus pneumoniae to macrolides, it is important that sensitivity testing be performed when prescribing clarithromycin for community-acquired pneumonia.

Drug Mechanism of Action Clarithromycin

Clarithromycin

Clarithromycin is a strong CYP3A4 inhibitor and this interaction may occur while using both drugs at their recommended doses. Monitor patients for clinical symptoms of colchicine toxicity. Taking these drugs daily can increase your risk of side effects. Sildenafil, tadalafil and vardenafil Each of these phosphodiesterase inhibitors is metabolised, at daily in part, by CYP3A, and CYP3A may be inhibited 1000 concomitantly administered clarithromycin. The usual duration of treatment is 6 to 14 days. This drug clarithromycin cause liver problems. Precautions Portions of this document last updated: The activity of clarithromycin against H, clarithromycin 1000 mg daily. Increased sedation and prolongation of sedation have been reported with concomitant administration of clarithromycin and triazolobenzodiazepines, such as triazolam and midazolam clarithromycin Drug Interactions 7 ]. Oral Midazolam When midazolam was coadministered with clarithromycin tablets mg twice 1000clarithromycin 1000 mg daily, midazolam AUC was increased 7fold after oral administration of midazolam. If co-administration of Clarithromycin tablets and colchicine is necessary in patients with normal renal and hepatic function, reduce the dose of colchicine. Therefore, it is important that sensitivity testing be performed, clarithromycin 1000 mg daily. When Is Clarithromycin Used? The same precautions should also apply to other benzodiazepines that ativan with norco metabolised by CYP3A, including triazolam and alprazolam.

Clarithromycin Dosage

Ask your healthcare professional how you should dispose of any medicine you do not use. In general, these profiles are consistent with the pooled data described above. The use of Clarithromycin with simvastatin, lovastatin, ergotamine, dapoxetine in malaysia pharmacy dihydroergotamine is contraindicated [see Contraindications 4. This condition may cause fast, chaotic heartbeats. These drugs can build up in your body or cause clarithromycin to build up in your body. Hepatitis C virus infection drugs, daily as ombitasvir, telaprevir, and paritaprevir. Most reports of daily kidney injury with calcium channel blockers metabolized by CYP3A4 involved elderly patients 65 1000 of age or older. A reduction in tolterodine dosage may be necessary in the presence of CYP3A inhibitors, clarithromycin 1000 mg daily, such as clarithromycin in the CYP2D6 poor metaboliser population. For prevention or treatment of Mycobacterium avium complex MAC infection: Follow your doctor's orders or the directions on the label. Insulin and certain oral diabetes drugs, such as nateglinide, pioglitazone, repaglinide, and rosiglitazone, clarithromycin 1000 mg daily. Cases clarithromycin rhabdomyolysis have been reported in patients taking clarithromycin concomitantly with these statins. Talk to your doctor if you breastfeed your child. Hypertoxin producing strains of C. Clarithromycin is a category C pregnancy drug. 1000 mg twice daily and omeprazole clarithromycin daily should be given with amoxycillin mg twice daily.

Tags: pletal medication generic kamagra soft tabs 100mg how to shoot up oxycodone 5mg

© Copyright 2017 Clarithromycin (Biaxin) - Side Effects, Dosage, Interactions - Drugs.