Coumadin tablets mg

Geriatric Use Of the total number of patients receiving warfarin sodium in controlled clinical trials for which data were available for analysis, patients No overall differences in effectiveness or safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Observe caution with administration of COUMADIN to elderly patients in any situation or with any physical condition where added risk of hemorrhage is present.

Renal Impairment Renal clearance is considered to be a minor determinant of anticoagulant response to warfarin. No dosage adjustment is necessary for patients with renal impairment. Hepatic Impairment Hepatic impairment can potentiate the response to warfarin through impaired synthesis of clotting factors and decreased metabolism of warfarin. Treatment The treatment of excessive anticoagulation is based on the level of the INR, the presence or absence of bleeding, and clinical circumstances.

If rapid re-anticoagulation is indicated, heparin may be preferable for initial therapy. A risk of hepatitis and other viral diseases is associated with the use of blood products; PCC and activated Factor VII are also associated with an increased risk of thrombosis. COUMADIN exposure during pregnancy causes a recognized pattern of major congenital malformations warfarin embryopathy and fetotoxicity , fatal fetal hemorrhage , and an increased risk of spontaneous abortion and fetal mortality.

Warnings for people with certain health conditions For people with high blood pressure: You may have a higher risk of bleeding if you take warfarin.

For people with history of gastrointestinal bleeding: If you have a history of stomach or intestinal bleeding, warfarin may increase your risk of bleeding. For people with heart disease or stroke: If you have heart disease or a history of stroke, your blood vessels may already be damaged and can easily bleed.

Warfarin may increase your risk of bleeding. For people with low blood count or cancer: Some cancers can cause internal bleeding. For people who have had head trauma: Warfarin thins your blood. For people with kidney problems: If you have a history of kidney disease, warfarin increases your risk of serious kidney damage. In addition, you have a higher bleeding risk when taking warfarin.

For both of these reasons, your doctor will likely monitor your INR international normalized ratio closely to check how your blood is clotting. Warnings for other groups For pregnant women: Warfarin should not be used during pregnancy except in women with mechanical heart valves, who are at high risk of clots. A clot can harm both the mother and the baby. Warfarin should be used during pregnancy only if the potential benefit justifies the potential risk.

Women who are breastfeeding: Warfarin may pass through breast milk. Your doctor may give you a lower warfarin dose. This dosage information is for warfarin oral tablet. All possible dosages and forms may not be included here.

Your dose, form, and how often you take it will depend on: The typical starting dose is 5 mg to 10 mg once per day. Your dose may change over time based on your test and your condition. Avoid activities such as contact sports. If you fall or injure yourself, especially if you hit your head, call your doctor right away. Your doctor may need to check you. However, consult your doctor or pharmacist before switching warfarin products.

Be careful not to take more than one medication that contains warfarin unless specifically directed by the doctor or health care provider who is monitoring your warfarin treatment. Older adults may be at greater risk for bleeding while using this drug.

This medication is not recommended for use during pregnancy because of serious possibly fatal harm to an unborn baby. Discuss with your doctor the use of reliable forms of birth control while taking this medication and for 1 month after stopping the medication. If you become pregnant or think you may be pregnant, tell your doctor right away.

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