Atherosclerosis is due to build up of fatty deposits in your arteries. Why it is important to keep taking Crestor Crestor is used to correct the levels of fatty substances in the blood called lipids, the most common of which is cholesterol. For most people, high cholesterol does not affect the way they feel because it does not produce any symptoms. However, if it is left untreated, fatty deposits can build up in the walls of your blood vessels causing them to narrow.

Sometimes, these narrowed blood vessels can get blocked which can cut off the blood supply to the heart or brain leading to a heart attack or a stroke. By lowering your cholesterol levels, you can reduce your risk of having a heart attack, a stroke or related health problems. You need to keep taking Crestor, even if it has got your cholesterol to the right level, because it prevents your cholesterol levels from creeping up again and causing build up of fatty deposits.

However, you should stop if your doctor tells you to do so, or you have become pregnant. If you have ever had an allergic reaction to Crestor, or to any of its ingredients. If you are pregnant or breast-feeding. If you become pregnant while taking Crestor stop taking it immediately and tell your doctor. Women should avoid becoming pregnant while taking Crestor by using suitable contraception.

If you have liver disease. If you have severe kidney problems. If you have repeated or unexplained muscle aches or pains. If you take a drug called ciclosporin used, for example, after organ transplants. If any of the above applies to you or you are in doubt , please go back and see your doctor. In addition, do not take Crestor 40 mg the highest dose: If you have moderate kidney problems if in doubt, please ask your doctor.

If your thyroid gland is not working properly. If you have had any repeated or unexplained muscle aches or pains, a personal or family history of muscle problems, or a previous history of muscle problems when taking other cholesterol-lowering medicines.

If you regularly drink large amounts of alcohol. If you take other medicines called fibrates to lower your cholesterol. Warnings and precautions Talk to your doctor or pharmacist before taking Crestor. If you have problems with your kidneys. If you have problems with your liver. If you have had repeated or unexplained muscle aches or pains, a personal or family history of muscle problems, or a previous history of muscle problems when taking other cholesterol-lowering medicines.

Tell your doctor immediately if you have unexplained muscle aches or pains especially if you feel unwell or have a fever. Also tell your doctor or pharmacist if you have a muscle weakness that is constant. Please read this leaflet carefully, even if you have taken other medicines for high cholesterol before. If you take medicines used to treat the HIV infection e.

If you are taking or have taken in the last 7 days a medicine called fusidic acid a medicine for bacterial infection , orally or by injection. The combination of fusidic acid and Crestor can lead to serious muscle problems rhabdomyolysis , please see Other medicines and Crestor.

If you are over 70 as your doctor needs to choose the right start dose of Crestor to suit you If you have severe respiratory failure. Your doctor needs to choose the right start dose of Crestor to suit you. If any of the above applies to you or if you are not sure: Do not take Crestor 40 mg the highest dose and check with your doctor or pharmacist before you actually start taking any dose of Crestor. In a small number of people, statins can affect the liver.

This is identified by a simple test which looks for increased levels of liver enzymes in the blood. For this reason, your doctor will usually carry out this blood test liver function test before and during treatment with Crestor.

While you are on this medicine your doctor will monitor you closely if you have diabetes or are at risk of developing diabetes. You are likely to be at risk of developing diabetes if you have high levels of sugars and fats in your blood, are overweight and have high blood pressure.

Children and adolescents If the patient is under 6 years old: Crestor should not be given to children younger than 6 years. If the patient is below 18 years of age: The Crestor 40 mg tablet is not suitable for use in children and adolescents below 18 years of age. Other medicines and Crestor Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines Tell your doctor if you are taking any of the following: The effects of these medicines could be changed by Crestor or they could change the effect of Crestor.

If you need to take oral fusidic acid to treat a bacterial infection you will need to temporarily stop using this medicine. Your doctor will tell you when it is safe to restart Crestor. Taking Crestor with fusidic acid may rarely lead to muscle weakness, tenderness or pain rhabdomyolysis.

See more information regarding rhabdomyolysis in Section 4. Pregnancy and breast-feeding Do not take Crestor if you are pregnant or breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine. In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required. Hemodialysis does not significantly enhance clearance of rosuvastatin. Crestor Description Crestor rosuvastatin calcium is a synthetic lipid-lowering agent for oral administration.

The chemical name for rosuvastatin calcium is bis[ E [4- 4-fluorophenyl isopropyl[methyl methylsulfonyl amino] pyrimidinyl] 3R,5S -3,5-dihydroxyheptenoic acid] calcium salt with the following structural formula: Rosuvastatin calcium is a white amorphous powder that is sparingly soluble in water and methanol, and slightly soluble in ethanol. In vivo studies in animals, and in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for cholesterol lowering.

In in vivo and in vitro studies, rosuvastatin produces its lipid-modifying effects in two ways. Administration of Crestor with food did not affect the AUC of rosuvastatin. The AUC of rosuvastatin does not differ following evening or morning drug administration. Distribution Mean volume of distribution at steady-state of rosuvastatin is approximately liters. This binding is reversible and independent of plasma concentrations. Specific Populations Race A population pharmacokinetic analysis revealed no clinically relevant differences in pharmacokinetics among Caucasian, Hispanic, and Black or Afro-Caribbean groups.

Gender There were no differences in plasma concentrations of rosuvastatin between men and women. Pediatric In a population pharmacokinetic analysis of two pediatric trials involving patients with heterozygous familial hypercholesterolemia 10 to 17 years of age and 8 to 17 years of age, respectively, rosuvastatin exposure appeared comparable to or lower than rosuvastatin exposure in adult patients.

Hepatic Impairment In patients with chronic alcohol liver disease, plasma concentrations of rosuvastatin were modestly increased. Drug-Drug Interactions Rosuvastatin clearance is not dependent on metabolism by cytochrome P 3A4 to a clinically significant extent. Rosuvastatin is a substrate for certain transporter proteins including the hepatic uptake transporter organic anion-transporting polyprotein 1B1 OATP1B1 and efflux transporter breast cancer resistance protein BCRP. Concomitant administration of Crestor with medications that are inhibitors of these transporter proteins e.

It is recommended that prescribers consult the relevant product information when considering administration of such products together with Crestor. A study found at least 32 million Americans were taking statins.

In , the U. The task force said anyone over the age of 40 should be screened even if they had no history of CVD. The task force based its recommendations on age and CVD risk factors. Crestor Side Effects Crestor side effects include muscle pain and damage. Crestor is also linked to cataracts, kidney and liver damage, and a possible increased risk for developing diabetes.

Hundreds of patients who suffered severe muscle injuries, diabetes or liver damage after taking Crestor have filed lawsuits over the drug. But in a February financial statement, AstraZeneca announced it had resolved all product liability lawsuits over Crestor. The higher the dose, the greater the risk of certain side effects. Food and Drug Administration approved Crestor in for use in patients with bad cholesterol and a history of heart disease. By the end of , more than countries approved the drug.

Major trials and studies showed a 9 to 12 percent increase in the risk of diabetes for people on statins. It warned doctors the drug could raise blood sugar levels. Fact Studies show statins like Crestor increase the risk of diabetes by up to 12 percent. The FDA announced further label changes in March Crestor label changes included: Recommended liver enzymes be tested before prescribing Crestor and when clinically necessary thereafter Adverse event information Added side effects including memory loss or impairment, confusion, forgetfulness and amnesia Lovastatin Drug Interactions Warned that Crestor should never be taken with Mevacor lovastatin , another cholesterol medicine Blood sugar Included information that increases in blood sugar levels had been reported with use of Crestor and other statins Protease Inhibitor Drug Interactions Warned that taking Crestor or other statins with HIV or hepatitis C virus HCV medicines called protease inhibitors may raise statin levels in the blood this increases the risk for muscle injury, including rhabdomyolysis, which can result in kidney failure Crestor Recalls Public Citizen petitioned the FDA in and to recall Crestor.

Rhabdomyolysis is a severe form of muscle damage that can harm the kidneys and is sometimes fatal. Public Citizen demanded the FDA recall the drug before any further incidents of rhabdomyolysis, kidney failure or kidney damage could occur.

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Please read this leaflet carefully, even if you have taken other medicines for high cholesterol before. CRP levels rise in response to inflammation throughout the body. This offer is valid for prescription purchased through a mail-order pharmacy. Pregnancy and breast-feeding Do not take Crestor if you are pregnant or breast-feeding. Because it is known that the risk of myopathy during treatment with HMG-CoA reductase inhibitors is increased with concomitant use of fenofibrates, caution should be used when prescribing fenofibrates with Crestor [see Warnings and Precautions 5, crestor 40 mg information. Take Crestor once daily. You can also report side effects directly via the Yellow Card Scheme Website: What Is Crestor Used to Treat? Increase in information enzymes in the blood. If you take a drug called ciclosporin used, crestor 40 mg information, for example, after organ transplants. Cholesterol obstructs blood flow through the body.

rosuvastatin (Crestor)

Food and Drug Administration approved Crestor in to lower cholesterol. Doctors prescribe statins to eliminate the buildup of cholesterol in the arteries. Take your dose once a day. Nontransferable, crestor 40 mg information, limited to one per person, cannot be combined with any other offer. Jaundice yellowing of the skin and eyeshepatitis an inflamed livertraces of blood in your urine, damage to the nerves of your legs and arms such as numbnessjoint pain, memory information and breast enlargement in men gynaecomastia, crestor 40 mg information. The usual Crestor starting dose is 10 mg to crestor mg once daily. Hepatic Impairment Crestor is contraindicated in patients with active liver disease, which may include unexplained persistent elevations of hepatic transaminase levels. If you are enrolled in a state or federally funded information insurance program, you may not use this rebate form even if you elect to crestor processed as an uninsured cash-paying patient. There have been crestor reports of immune-mediated necrotizing myopathy associated with statin use [see Warnings and Precautions 5. You have been prescribed Crestor because: Print text only What is a Patient Information Leaflet and why is it useful? The maximum daily dose of Crestor is 40 mg. Because HMG-CoA reductase inhibitors information cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, crestor 40 mg information, Crestor may cause fetal harm when administered to pregnant women. Food and Drug Administration approved Crestor in for use in patients with bad capoten e captopril and a history of information disease. There was no detectable effect of Crestor on growth, crestor 40 mg information, weight, BMI body mass indexor sexual maturation [see Clinical Studies If crestor patient is below 18 years of age:

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© Copyright 2017 Crestor 40 mg information. M.D. recommended.