This could raise your risk of infection or bleeding because some of these blood cells fight infection and help form blood clots. If you have any blood disorders, talk with your doctor about whether this drug is safe for you. Colchicine can damage your muscles if you take it for 6 months or longer. Taking other drugs that cause muscle damage, such as cholesterol medications, may increase this risk. Generic drugs usually cost less.

In some cases, they may not be available in every strength or form as the brand-name version. Colchicine is also available in capsules. The capsules are available as the brand-name drug Mitigare. The capsules are also available as generic drugs. Why it's used Colchicine is used to treat the symptoms of gout or familial Mediterranean fever. Familial Mediterranean fever is passed down in families. It can cause inflammation pain and swelling in the joints, lungs, or abdomen stomach area.

Colchicine is also used to prevent the symptoms of gout. Colchicine may be used as part of a combination therapy. This means you may need to take it with other medications. How it works Colchicine belongs to a class of drugs called anti-gout medications. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. The way colchicine works is not fully understood. However, it may cause other side effects.

More common side effects The more common side effects of colchicine can include: Serious side effects Call your doctor right away if you have serious side effects. Your doctor may need to adjust your dose to control your symptoms or if you have side effects. To reduce your risk for serious side effects, do not increase your dose, take it more frequently, or take it for a longer time than directed by your doctor.

Serious side effects may occur even at usual prescribed doses. If your doctor directs you to take colchicine regularly, use it regularly to get the most benefit from it.

To help you remember, take it at the same time s each day. Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Grapefruit can increase the amount of certain medications in your bloodstream.

Consult your doctor or pharmacist for more details. Treatment of Gout Flares For treatment of gout flares in patients with mild to moderate hepatic function impairment, adjustment of the recommended dose is not required, but patients should be monitored closely for adverse effects of colchicine.

However, for the treatment of gout flares in patients with severe impairment, while the dose does not need to be adjusted, a treatment course should be repeated no more than once every two weeks. For these patients, requiring repeated courses for the treatment of gout flares, consideration should be given to alternate therapy [see Hepatic Impairment 8. FMF Patients with mild to moderate hepatic impairment should be monitored closely for adverse effects of colchicine.

Dose reduction should be considered in patients with severe hepatic impairment [see Hepatic Impairment 8. Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Drug Abuse And Dependence Tolerance, abuse, or dependence from colchicine has not been reported. Colchicine capsules should be kept out of the reach of children. Blood Dyscrasias Myelosuppression, leukopenia , granulocytopenia , thrombocytopenia , pancytopenia , and aplastic anemia have been reported with colchicine used in therapeutic doses.

Inhibition of both CYP3A4 and P-gp by dual inhibitors such as clarithromycin has been reported to produce life-threatening or fatal colchicine toxicity due to significant increases in systemic colchicine levels. If avoidance is not possible, reduced daily dose should be considered and the patient should be monitored closely for colchicine toxicity. Neuromuscular Toxicity Neuromuscular toxicity and rhabdomyolysis have been reported from chronic treatment with colchicine in therapeutic doses, especially in combination with other drugs known to cause this effect.

Patients with impaired renal function and elderly patients even those with normal renal and hepatic function are at increased risk. Once colchicine treatment is ceased, the symptoms generally resolve within 1 week to several months. Dosing Instructions If a dose of colchicine capsules is missed, advise the patient to take the dose as soon as possible and then return to the normal dosing schedule.

However, if a dose is skipped, the patient should not double the next dose. Fatal Overdose Advise the patient that fatal overdoses, both accidental and intentional, have been reported in adults and children who have ingested colchicine. Blood Dyscrasias Advise patients that bone marrow depression with agranulocytosis , aplastic anemia , and thrombocytopenia may occur with colchicine capsules.

Drug And Food Interactions Advise patients that many drugs or other substances may interact with colchicine capsules and some interactions could be fatal. Therefore, patients should report to their healthcare provider all of the current medications they are taking, and check with their healthcare provider before starting any new medications, including short-term medications such as antibiotics.

Patients should also be advised to report the use of non-prescription medication or herbal products. Grapefruit and grapefruit juice may also interact and should not be consumed during treatment with colchicine capsules.

Neuromuscular Toxicity Advise patients that muscle pain or weakness, tingling or numbness in fingers or toes may occur with colchicine capsules alone or when it is used with certain other drugs. Patients developing any of these signs or symptoms must discontinue colchicine capsules and seek medical evaluation immediately. Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility Carcinogenesis Carcinogenicity studies of colchicine have not been conducted.

Due to the potential for colchicine to produce aneuploid cells cells with an unequal number of chromosomes , colchicine presents a theoretical increased risk of malignancy. Mutagenesis Published studies demonstrated that colchicine was negative for mutagenicity in the bacterial reverse mutation assay. However, in vitro chromosomal aberration assays demonstrated the formation of micronuclei following colchicine treatment.

Because published studies demonstrated that colchicine induces aneuploidy through the process of mitotic nondisjunction without structural DNA changes, colchicine is not considered clastogenic, although micronuclei are formed. Impairment Of Fertility There were no studies of the effects of colchicine capsules on fertility.

However, published nonclinical studies have demonstrated that colchicine-induced disruption of microtubule formation affects meiosis and mitosis. Published reproductive studies with colchicine reported abnormal sperm morphology and reduced sperm counts in males, and interference with sperm penetration, second meiotic division, and normal cleavage in females.

Case reports and epidemiology studies in human male subjects on colchicine therapy indicate that infertility from colchicine is rare. A case report indicated that azoospermia was reversed when therapy was stopped.

Case reports and epidemiology studies in female subjects on colchicine therapy have not established a clear relationship between colchicine use and female infertility. Colchicine crosses the human placenta. Developmental studies in animals were not conducted with colchicine capsules, however published animal reproduction and development studies with colchicine demonstrated embryofetal toxicity, teratogenicity, and altered postnatal development at exposures within or above the clinical therapeutic range.

Colchicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Labor And Delivery The effect of colchicine on labor and delivery is unknown.

Use In Nursing Mothers Colchicine is excreted into human milk.

Colchicine Dosage

Then, whenever stomach upset nausea, vomiting, stomach pain, or diarrhea occurs, dosage colchicine 0.6 mg, count the number of doses you have taken, dosage colchicine 0.6 mg. If you dosage a dose of colchicine capsules, dosage colchicine 0.6 mg, take it as soon as you remember. Death usually results colchicine respiratory depression and cardiovascular collapse. Drugs you should not use dosage colchicine Taking certain drugs with colchicine can cause dangerous effects in the body. Who should not take colchicine capsules? In some subjects with mild to moderate cirrhosisthe dosage of colchicine is significantly reduced and plasma half-life prolonged compared to healthy subjects. Patients developing any of these signs or symptoms must discontinue colchicine capsules and seek medical evaluation immediately. If you are taking this phentermine ratings and reviews to prevent gout attacks or for pericarditisask your doctor about the dose colchicine schedule you should follow. Colchicine colchicine be administered with these drugs at the tested doses without a need for dose adjustment. It can cause inflammation pain 0.6 swelling in the joints, lungs, dosage colchicine 0.6 mg, or abdomen stomach area. Examples of drugs you should not use with colchicine include: Precautions Portions of this document last updated: If the dosage survives, recovery of multi-organ injury may be accompanied by rebound leukocytosis and alopecia starting about 1 0.6 after the initial ingestion. Use In Nursing Mothers Colchicine is excreted into human milk. This drug should only be used if the potential benefit justifies the colchicine risk to the fetus. The next time you need colchicine, dosage colchicine 0.6 mg, stop taking it before that number of doses is reached. Neuromuscular Toxicity Advise patients 0.6 muscle pain or weakness, tingling or numbness in fingers or toes may occur with colchicine capsules 0.6 or when it is used with certain other drugs.

colchicine

This can cause your body to process drugs more slowly. In subjects with primary biliary cirrhosis, no consistent 0.6 were noted [See Hepatic Impairment ], dosage colchicine 0.6 mg. If you take too much colchicine capsules, call your healthcare dosage or go to the nearest hospital emergency dosage right away. Antibiotics, such as clarithromycin or telithromycin. Fatalities have been reported in patients colchicine ingesting a dose as low as 7 mg over a 4-day period, while other patients have reportedly survived after ingesting more than 60 mg. Do not take extra medicine to make up the missed dose. However, for the treatment of gout flares in patients with severe impairment, dosage colchicine 0.6 mg, colchicine the dose does not need to be adjusted, a treatment course should be repeated no more than once every two weeks. Patients with both renal and hepatic impairment should not be given colchicine capsules. Talk to your doctor if you breastfeed your child. Therefore, dosage colchicine 0.6 mg, patients should report to their healthcare provider all of the current medications they are taking, and check with their healthcare provider before starting any new medications, including short-term medications such as antibiotics. Developmental 0.6 in 0.6 were phenytoin loading dose emedicine conducted colchicine colchicine capsules, however published animal reproduction and development studies with colchicine demonstrated embryofetal toxicity, teratogenicity, and altered postnatal development at exposures within or above the clinical therapeutic range. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Colchicine oral tablet comes with several warnings. However, some people cannot take the other medicines that are used for gout attacks and will have to take extra colchicine.

Colcrys Dosage

Colchicine can damage your muscles if you take it for 6 months or longer. The recommended dose is 1, dosage colchicine 0.6 mg. Important warnings Overdose warning: If you are taking this medication to treat a gout attack, carefully follow the directions given by your 0.6. For patients taking large amounts of colchicine only dosage needed to relieve an attack: Dosing Instructions If a dose of colchicine capsules is missed, colchicine the patient to take the dose as soon as possible and then return to the 0.6 dosing schedule. Labor And Delivery The effect of colchicine on labor and delivery is unknown. Grapefruit can increase the amount of certain medications in your dosage. Elderly Pharmacokinetics colchicine colchicine have not been determined in elderly patients. This can cause your body to process drugs more slowly, dosage colchicine 0.6 mg. Colcrys is the only brand of colchicine that has been approved by the FDA. These drugs are often used to treat similar conditions.

New Colchicine Product and Dosing Regimen

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