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Hydrocodone And Acetaminophen (Oral Route) Side Effects - Mayo Clinic

Hydrocodone ulcer pain

Talk with your doctor Vicodin and Percocet are opioid pain medications that are similar in many ways. Some of the main ways in which they differ are strengths and cost. If your doctor feels you need Vicodin or Percocet for your pain, they will choose the drug for you based on several factors. These factors include your health history and how your body has reacted to pain medications in the past. If you have questions about your prescription or about either of these drugs, be sure to ask your doctor.

Questions to ask your doctor might include: Would one of these drugs benefit me more than the other? Should I be concerned about becoming addicted to this drug? Skin rashes and itching may result.

Hydrocodone overdose will manifest with decreased respiration and cyanosis, deep sleep somnolence progressing to stupor or coma with a cold clammy skin and skeletal muscle flaccidity weakness bradycardia slow heart rate and hypotension and eventually blood circulatory collapse, followed by cardiac arrest and death. DOSING Various products are available containing hydrocodone for use as an analgesic or cough suppressant anti-tussive. One such company is Abbott Pharmaceuticals for their product Vicodin.

As of May , Abbott voluntarily has changed formulations from a combination of hydrocodone which remains at 5mg, 7. Adrenal insufficiency may present with non-specific symptoms and signs such as nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. For the short-term generally less than 10 days management of acute pain, the recommended dose of hydrocodone bitartrate and ibuprofen tablets are one tablet every 4 to 6 hours, as necessary.

Hypotension Inform patients that hydrocodone bitartrate and ibuprofen tablets may cause orthostatic hypotension and syncope. Instruct patients how to recognize symptoms of low blood pressure and how to reduce the risk of serious consequences should hypotension occur e. Anaphylaxis Inform patients that anaphylaxis has been reported with ingredients contained in Hydrocodone Bitartrate and Ibuprofen Tablets.

Pregnancy Neonatal Opioid Withdrawal Syndrome Inform female patients of reproductive potential that prolonged use of hydrocodone bitartrate and ibuprofen tablets during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated see Boxed Warning , WARNINGS: Embryo-Fetal Toxicity Inform female patients of reproductive potential that hydrocodone bitartrate and ibuprofen tablets can cause fetal harm and to inform the prescriber of a known or suspected pregnancy.

Lactation Advise nursing mothers to monitor infants for increased sleepiness more than usual , breathing difficulties, or limpness. Infertility Inform patients that chronic use of opioids may cause reduced fertility. It is not known whether these effects on fertility are reversible. Carcinogenicity, Mutagenicity, Impairment of Fertility. Driving or Operating Heavy Machinery Inform patients that hydrocodone bitartrate and ibuprofen tablets may impair the ability to perform potentially hazardous activities such as driving a car or operating heavy machinery.

Risks of Driving and Operating Machinery. Cardiovascular Thrombotic Events Advise patients to be alert for the symptoms of cardiovascular thrombotic events, including chest pain, shortness of breath, weakness, or slurring of speech, and to report any of these symptoms to their healthcare provider immediately see WARNINGS: Gastrointestinal Bleeding, Ulceration, and Perforation Advise patients to report symptoms of ulcerations and bleeding, including epigastric pain, dyspepsia, melena, and hematemesis to their healthcare provider.

Hepatotoxicity Inform patients of the warning signs and symptoms of hepatotoxicity e. Heart Failure and Edema Advise patients to be alert for the symptoms of congestive heart failure including shortness of breath, unexplained weight gain, or edema and to contact their healthcare provider if such symptoms occur see WARNINGS: Heart Failure and Edema. Serious Skin Reactions Advise patients to stop hydrocodone bitartrate and ibuprofen tablets immediately if they develop any type of rash and to contact their healthcare provider as soon as possible see WARNINGS: Disposal of Unused Hydrocodone Bitartrate and Ibuprofen Tablets Advise patients to flush the unused tablets down the toilet when hydrocodone bitartrate and ibuprofen tablets are no longer needed or to contact the Drug Enforcement Agency DEA to find the location of an authorized collector Pharmacokinetics , resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to Hydrocodone Bitartrate and Ibuprofen Tablets.

If concomitant use is necessary, consider dosage reduction of hydrocodone bitartrate and ibuprofen tablets until stable drug effects are achieved. Monitor patients for respiratory depression and sedation at frequent intervals. If a CYP3A4 inhibitor is discontinued, consider a dosage increase of hydrocodone bitartrate and ibuprofen tablets until stable drug effects are achieved. Monitor for signs of opioid withdrawal. Pharmacokinetics , resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to hydrocodone see WARNINGS: Pharmacokinetics , which could increase or prolong both the therapeutic effects and adverse reactions, and may cause serious respiratory depression.

If concomitant use is necessary, consider a dosage increase of hydrocodone bitartrate and ibuprofen tablets until stable drug effects are achieved. If a CYP3A4 inducer is discontinued, consider hydrocodone bitartrate and ibuprofen tablets dosage reduction and monitor for signs of respiratory depression. Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.

Limit dosages and durations to the minimum required. Life- Threatening Respiratory Depression. Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors SSRIs , serotonin and norepinephrine reuptake inhibitors SNRIs , tricyclic antidepressants TCAs , triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system e. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.

Discontinue hydrocodone bitartrate and ibuprofen tablets if serotonin syndrome is suspected. If urgent use of an opioid is necessary with MAOIs such as phenelzine, tranylcypromine, linezolid, use test doses and frequent titration of small doses to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression.

The use of hydrocodone bitartrate and ibuprofen tablets are not recommended for patients taking MAOIs or within 14 days of stopping such treatment. Avoid concomitant use of these drugs. Muscle Relaxants Hydrocodone, as well as other opioid analgesics, may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.

Monitor patients for signs of urinary retention or reduced gastric motility when hydrocodone bitartrate and ibuprofen tablets are used concomitantly with anticholinergic drugs. Drugs That Interfere With Hemostasis Ibuprofen and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of ibuprofen and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone.

Serotonin release by platelets plays an important role in hemostasis. Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone.

Monitor patients with concomitant use of hydrocodone bitartrate and ibuprofen tablets with anticoagulants e. Concomitant use of hydrocodone bitartrate and ibuprofen tablets and analgesic doses of aspirin is not generally recommended because of the increased risk of bleeding see WARNINGS: During concomitant use of hydrocodone bitartrate and ibuprofen tablets and ACE-inhibitors, ARBs, or beta-blockers, monitor blood pressure to ensure that the desired blood pressure is obtained. In patients who are elderly, volume-depleted including those on diuretic therapy , or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.

Renal Toxicity and Hyperkalemia. These effects are usually reversible. When these drugs are administered concomitantly, patients should be adequately hydrated. Assess renal function at the beginning of the concomitant treatment and periodically thereafter. Diuretics Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics e.

During concomitant use of hydrocodone bitartrate and ibuprofen tablets with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects see WARNINGS: Digoxin The concomitant use of ibuprofen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. During concomitant use of hydrocodone bitartrate and ibuprofen tablets and digoxin, monitor serum digoxin levels.

Lithium NSAIDs have produced elevations in plasma lithium concentration and reductions in renal lithium clearance. During concomitant use of hydrocodone bitartrate and ibuprofen tablets and lithium, monitor patients for signs of lithium toxicity. During concomitant use of hydrocodone bitartrate and ibuprofen tablets and methotrexate, monitor patients for methotrexate toxicity. If acetaminophen doesn't help with your pain, see your doctor.

Other Options for Pain Relief Painkillers aren't the only answer for many of life's aches and pains. Many effective and safe alternatives don't have any side effects at all. Ice packs, for acute injuries such as a sprained ankle , can keep down swelling and ease pain. Heat with a hot towel or heating pad can be helpful for treating chronic overuse injuries. However, you shouldn't use heat on recent injuries. Physical activity can help reduce some kinds of discomfort, such as arthritis pain.

Relaxation with techniques such as yoga or meditation -- may reduce pain. Biofeedback may help as well. These approaches are best for pain that's amplified by stress, such as tension headaches. Nontraditional techniques with low risks -- such as acupuncture -- benefit some people.

Pain relief doesn't only come from a pill bottle. It should help simplify your choices when you're in the drugstore.

Keep in mind that you shouldn't use any over-the-counter painkiller on a regular basis. If you're in that much pain, you need to talk with your doctor. Experts aren't actually sure how it works, but it seems to affect chemicals that increase the feeling of pain.

Acetaminophen reduces pain and lowers fevers. It doesn't affect the natural lining of the stomach. Since it doesn't thin the blood , it doesn't increase the risk of bleeding either. It is safe for women who are pregnant and nursing. Side effects and risks. Experts say that acetaminophen is safe for people with ulcers. But like any drug, it can cause other side effects. Long-term use of acetaminophen in high doses -- especially when combined with caffeine Excedrin or codeine Tylenol with Codeine can cause kidney disease.

It may be less helpful for treating pain that's caused by inflammation, such as some types of arthritis. It blocks the effects of chemicals that increase the feeling of pain. Aspirin has earned its reputation as a "wonder drug.

It can also reduce inflammation, which means that it can treat the symptom pain and sometimes the cause swelling. Aspirin also lowers the risk of blood clots , heart attacks, and strokes, particularly in people at high risk of these problems.

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