What is minocycline 100 mg

It is recommended that the prophylactic use of minocycline be reserved for situations in which the risk of meningococcal meningitis is high. Oral minocycline is not indicated for the treatment of meningococcal infection.

Although no controlled clinical efficacy studies have been conducted, limited clinical data show that oral minocycline hydrochloride has been used successfully in the treatment of infections caused by Mycobacterium marinum. To reduce the development of drug-resistant bacteria and maintain the effectiveness of MINOCIN minocycline hydrochloride Pellet-Filled Capsules and other antibacterial drugs, MINOCIN minocycline hydrochloride Pellet-Filled Capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Ingestion of adequate amounts of fluids along with capsule and tablet forms of drugs in the tetracyclineclass is recommended to reduce the risk of esophageal irritation and ulceration.

The pellet-filled capsules should be swallowed whole. Alternatively, if more frequent doses are preferred, two or four 50 mg pellet-filled capsules may be given initially followed by one 50 mg capsule 4 times daily.

Uncomplicated gonococcal infections other than urethritis and anorectal infections in men: In the treatment of uncomplicated gonococcal urethritis in men, mg every 12 hours for 5 days is recommended. For the treatment of syphilis, the usual dosage of minocycline hydrochloride should be administered over a period of 10 to 15 days.

Close follow-up, including laboratory tests, is recommended. In the treatment of meningococcal carrier state, the recommended dosage is mg every 12 hours for 5 days. Although optimal doses have not been established, mg every 12 hours for 6 to 8 weeks have been used successfully in a limited number of cases. Uncomplicated urethral, endocervical, or rectal infection in adults caused by Chlamydia trachomatis or Ureaplasma urealyticum: Current data are insufficient to determine if a dosage adjustment is warranted.

The total daily dosage should not exceed mg in 24 hours. However, due to the anti-anabolic effect of tetracyclines, BUN and creatinine should be monitored. Each capsule contains pellets of minocycline HCl equivalent to mg of minocycline, supplied as follows: Each capsule contains pellets of minocycline HCl equivalent to 75 mg of minocycline, supplied as follows: NDC Bottle of 60 50 mg, two-piece, hard-shell capsule with an opaque yellow cap and a transparent green body, printed in black ink with "Onset" over "M" on one half and "Onset" over "50 mg" on the other half.

Each capsule contains pellets of minocycline HCl equivalent to 50 mg of minocycline, supplied as follows: Protect from light, moisture, and excessive heat. Dispense in a tight, light-resistant container as defined in the USP. The following adverse reactions have been observed in patients receiving tetracyclines. Body as a whole: Fever, and discoloration of secretions. Anorexia , nausea, vomiting , diarrhea, dyspepsia , stomatitis, glossitis , dysphagia , enamel hypoplasia , enterocolitis, pseudomembranous colitis , pancreatitis , inflammatory lesions with monilial overgrowth in the oral and anogenital regions.

Instances of esophagitis and esophageal ulcerations have been reported in patients taking the tetracycline -class antibiotics in capsule and tablet form. Most of these patients took the medication immediately before going to bed.

Hyperbilirubinemia , hepatic cholestasis, increases in liver enzymes, fatal hepatic failure, and jaundice. Hepatitis , including autoimmune hepatitis , and liver failure have been reported. Alopecia , erythema nodosum , hyperpigmentation of nails, pruritus , toxic epidermal necrolysis, and vasculitis. Maculopapular and erythematous rashes. Exfoliative dermatitis has been reported. Fixed drug eruptions have been reported.

Lesions occurring on the glans penis have caused balanitis. Erythema multiforme and Stevens-Johnson syndrome have been reported. Photosensitivity is discussed above. Pigmentation of the skin and mucous membranes has been reported.

Cough, dyspnea , bronchospasm, exacerbation of asthma , and pneumonitis. Elevations in BUN have been reported and are apparently dose related.

Reversible acute renal failure has been reported. Arthralgia , arthritis , bone discoloration, myalgia , joint stiffness , and joint swelling. A transient lupus -like syndrome and serum sickness-like reactions also have been reported. Agranulocytosis , hemolytic anemia , thrombocytopenia , leukopenia , neutropenia , pancytopenia , and eosinophilia have been reported. Convulsions, dizziness, hypesthesia, paresthesia , sedation, and vertigo.

Alopecia , erythema nodosum , hyperpigmentation of nails, pruritus , toxic epidermal necrolysis, and vasculitis. Maculopapular and erythematous rashes. Exfoliative dermatitis has been reported. Fixed drug eruptions have been reported. Lesions occurring on the glans penis have caused balanitis. Erythema multiforme and Stevens-Johnson syndrome have been reported. Photosensitivity is discussed above. Pigmentation of the skin and mucous membranes has been reported.

Cough, dyspnea , bronchospasm, exacerbation of asthma , and pneumonitis. Elevations in BUN have been reported and are apparently dose related.

Reversible acute renal failure has been reported. Arthralgia , arthritis , bone discoloration, myalgia , joint stiffness , and joint swelling. Pigmentation of the skin and mucous membranes has been reported. Cough, dyspnea, bronchospasm, exacerbation of asthma, and pneumonitis. Reversible acute renal failure has been reported. Arthralgia, arthritis, bone discoloration, myalgia, joint stiffness, and joint swelling. A transient lupus-like syndrome and serum sickness-like reactions also have been reported.

Agranulocytosis, hemolytic anemia, thrombocytopenia, leukopenia, neutropenia, pancytopenia, and eosinophilia have been reported. Convulsions, dizziness, hypesthesia, paresthesia, sedation, and vertigo. Headache has also been reported. Thyroid cancer has been reported in the postmarketing setting in association with Minocycline products. When Minocycline therapy is given over prolonged periods, monitoring for signs of thyroid cancer should be considered.

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. Cases of abnormal thyroid function have been reported. Tinnitus and decreased hearing have been reported in patients on Minocycline hydrochloride.

The following syndromes have been reported. In some cases involving these syndromes, death has been reported. As with other serious adverse reactions, if any of these syndromes are recognized, the drug should be discontinued immediately: Hypersensitivity syndrome consisting of cutaneous reaction such as rash or exfoliative dermatitis , eosinophilia, and one or more of the following: Fever and lymphadenopathy may be present.

Lupus-like syndrome consisting of positive antinuclear antibody; arthralgia, arthritis, joint stiffness, or joint swelling; and one or more of the following: Serum sickness-like syndrome consisting of fever; urticaria or rash; and arthralgia, arthritis, joint stiffness, or joint swelling and lymphadenopathy. Eosinophilia may be present.

Overdosage The adverse events more commonly seen in overdose are dizziness, nausea, and vomiting. No specific antidote for Minocycline is known. In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures.

Minocycline is not removed in significant quantities by hemodialysis or peritoneal dialysis. Ingestion of adequate amounts of fluids along with capsule and tablet forms of drugs in the tetracycline-class is recommended to reduce the risk of esophageal irritation and ulceration.

The capsules should be swallowed whole. Adults The usual dosage of Minocycline hydrochloride capsules is mg initially followed by mg every 12 hours. Alternatively, if more frequent doses are preferred, two or four 50 mg capsules may be given initially followed by one 50 mg capsule 4 times daily. Uncomplicated gonococcal infections other than urethritis and anorectal infections in men: In the treatment of uncomplicated gonococcal urethritis in men, mg every 12 hours for 5 days is recommended.

For the treatment of syphilis, the usual dosage of Minocycline hydrochloride should be administered over a period of 10 to 15 days. Close follow-up, including laboratory tests, is recommended. In the treatment of meningococcal carrier state, the recommended dosage is mg every 12 hours for 5 days. Although optimal doses have not been established, mg every 12 hours for 6 to 8 weeks have been used successfully in a limited number of cases.

Uncomplicated urethral, endocervical, or rectal infection in adults caused by Chlamydia trachomatis or Ureaplasma urealyticum: Ingestion of adequate amounts of fluids along with capsule and tablet forms of drugs in the tetracycline class is recommended to reduce the risk of esophageal irritation and ulceration. Current data are insufficient to determine if a dosage adjustment is warranted. The total daily dosage should not exceed mg in 24 hours. Protect from light, moisture, and excessive heat.

Dispense in a tight, light-resistant container as defined in the USP. In the rat, chronic treatment with Minocycline hydrochloride has resulted in goiter accompanied by elevated radioactive iodine uptake and evidence of thyroid tumor production.

Minocycline hydrochloride has also been found to produce thyroid hyperplasia in rats and dogs. Monday through Friday from 9: There may be new information. This leaflet does not take the place of talking to your doctor about your medical condition or treatment.

What are Minocycline hydrochloride capsules? Minocycline hydrochloride capsules are a tetracycline-class antibiotic medicine. Minocycline hydrochloride capsules are used to treat certain infections caused by bacteria. These include infections of the skin, respiratory tract, urinary tract, some sexually transmitted diseases, and others. Minocycline hydrochloride capsules may be used along with other treatments for severe acne.

Sometimes other germs, called viruses, cause infections. The common cold is a virus. Minocycline hydrochloride capsules, like other antibiotics, do not treat viruses. Who should not use Minocycline hydrochloride capsules?

Do not take Minocycline hydrochloride capsules if you are allergic to Minocycline or other tetracycline antibiotics. Ask your doctor or pharmacist for a list of these medications if you are not sure. See the end of this leaflet for a complete list of ingredients in Minocycline hydrochloride capsules. Minocycline hydrochloride capsules are not recommended for pregnant women or children up to 8 years old because: Minocycline hydrochloride capsules may harm an unborn baby 2.

Minocycline hydrochloride capsules may permanently turn a baby's or child's teeth yellow-gray-brown during tooth development. What should I tell my doctor before starting Minocycline hydrochloride capsules? Tell your doctor about all of your medical conditions, including if you: Minocycline hydrochloride capsules may harm your unborn baby.

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