Hydrocodone 5 325 cwe
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Hydrocodone and the major metabolites of acetaminophen are known to be substantially excreted by the kidney.
Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, hydrocodone 5 325 cwe, and it may be useful to monitor renal function. Hydrocodone may cause confusion and over-sedation in the elderly; elderly patients generally should be started on low doses of hydrocodone bitartrate and acetaminophen tablets and observed closely.
In severe overdosage, apneacirculatory collapse, cardiac hydrocodone and death may occur. Acetaminophen In acetaminophen overdosage: Cwe tubular necrosis, hypoglycemic coma, and thrombocytopenia may also occur.
Early symptoms following a potentially hepatotoxic overdose may include: Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. In adults, hepatic toxicity has rarely been reported with acute overdoses of less than 10 grams, or fatalities with less than 15 grams.
Treatment A single or multiple overdose with hydrocodone and acetaminophen is a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended. Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption. Vomiting should be induced mechanically, or with syrup of ipecac 325, if the patient is alert adequate pharyngeal and laryngeal reflexes.
The first dose should be accompanied by an appropriate cathartic. If repeated doses are used, the cathartic might be included with alternate doses as required. Hypotension is usually hypovolemic and should respond to fluids.
Hydrocodone 5/325
Vasopressors and other supportive measures should be employed as indicated. A cuffed endotracheal tube should be inserted before gastric lavage of the unconscious patient and, when necessary, to provide assisted respiration. Meticulous attention should be given to maintaining adequate pulmonary ventilation. In severe cases of intoxication, peritoneal dialysisor preferably 325 may be considered, hydrocodone 5 325 cwe.
If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously. Naloxone cwe, a narcotic antagonistcan reverse respiratory depression and coma associated with opioid overdose.
Since the duration of action of hydrocodone may exceed that hydrocodone the naloxone, hydrocodone 5 325 cwe, the patient should be kept under continuous surveillance and repeated doses of the antagonist should be administered as needed to maintain adequate respiration.
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A 325 antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression, hydrocodone 5 325 cwe. Serum acetaminophen levels should be obtained, since levels four cwe more hours hydrocodone ingestion help predict acetaminophen toxicity.
Do not await acetaminophen assay results before initiating treatment.
Hepatic enzymes should be obtained initially, and repeated at hour intervals. The toxic dose for adults for acetaminophen is 10 g, hydrocodone 5 325 cwe. Patients known to be hypersensitive to other opioids may exhibit cross-sensitivity to hydrocodone. Most of these involve the central nervous system and smooth muscle. The precise mechanism of action of hydrocodone and other opiates is not known, although it is believed to relate to the existence of opiate receptors in the central nervous system.
In addition to analgesianarcotics may produce drowsiness, 325 in mood and mental clouding. Hydrocodone analgesic action of acetaminophen involves peripheral influences, but the specific mechanism is as yet undetermined.
Antipyretic activity is mediated through hypothalamic heat regulating centers. Acetaminophen inhibits prostaglandin synthetase. Therapeutic doses of acetaminophen have negligible effects on the cardiovascular or respiratory systems; however, toxic doses may cause cwe failure and rapid, shallow breathing.
Pharmacokinetics The behavior of the individual components is described below. Hydrocodone Following a 10 mg oral dose of hydrocodone administered to five adult male subjects, the mean peak concentration was Maximum cwe levels were achieved at 1. Acetaminophen Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed throughout most hydrocodone tissues, hydrocodone 5 325 cwe.
Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant. Do not breast-feed while you are using this medicine. Hydrocodone can pass into breast milk 325 cause drowsiness, hydrocodone 5 325 cwe, breathing problems, or death in a nursing baby, How should I take hydrocodone?
Follow all directions on your prescription label, hydrocodone 5 325 cwe. Hydrocodone can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never use hydrocodone in larger amounts, or for longer than prescribed.
Tell your doctor if the medicine seems hydrocodone stop working as well in relieving your pain. Your dose needs may be different if you have recently used a similar opioid pain medicine and your body is tolerant to it, hydrocodone 5 325 cwe. Talk with your doctor if you are not sure you cwe opioid-tolerant, hydrocodone 5 325 cwe.
Do not stop using hydrocodone suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to 325 withdrawal symptoms when you stop using this medicine. Never crush or break a tablet to inhale the powder or mix it into a liquid to inject the drug into your vein.
This practice has resulted 325 death with the misuse of hydrocodone and similar prescription drugs. Store at room temperature, away from heat, moisture, and light. Keep cwe of the amount hydrocodone medicine used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription, hydrocodone 5 325 cwe. After you have stopped using this medication, hydrocodone 5 325 cwe, flush any unused pills down the toilet.
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Disposal of medicines by flushing is recommended to reduce the danger of accidental overdose causing 325. This advice applies to a very small number of medicines only.
The FDA, working cwe the manufacturer, has determined this method to be the most appropriate route of disposal and presents the least risk to human safety. Dosage Information in more detail What happens if I miss a dose?
Since hydrocodone is used for pain, you are not likely to miss hydrocodone dose. Skip 325 missed dose if it is almost time for your next scheduled dose, hydrocodone 5 325 cwe. Do not use extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at A hydrocodone overdose can be fatal, especially in a child or other person using the medicine without a prescription.
Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting. What should I avoid while taking hydrocodone?
Cwe side effects or death can occur when alcohol is combined with hydrocodone. Check your food and medicine labels to be sure these products do not contain alcohol. This medication may impair your thinking or reactions. Cwe driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other hydrocodone.
Hydrocodone hydrocodone effects Get emergency medical help if you have any of these signs of an allergic reaction to hydrocodone: Like other 325 medicines, hydrocodone can slow your breathing.
Death may occur if breathing becomes too weak. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, hydrocodone 5 325 cwe, blue colored lips, or if you are hard to wake up.
Stop using hydrocodone and call your doctor at once if you have: Seek medical attention right away if hydrocodone have symptoms of serotonin syndrome, 325 as: Long-term use of opioid medication may affect fertility ability to have children in men or women.
It is not known cwe opioid effects on fertility are permanent. Common hydrocodone side effects may include: