Irbesartan pharmaceutical composition - USA - Pharmaceutical compositions containing irbesartan - Google Patents
By compressing the mixture using tabletting equipment, tablets were prepared for each potency having the composition as shown in the table above.
FIELD OF THE INVENTION
The formulations were made by wet granulation, as described above. The formulations were made by wet granulation as described above. Variations of those preferred embodiments may become apparent to those of ordinary skill in the art upon reading the foregoing description.
The inventors expect skilled artisans to employ such variations as appropriate, and the inventors intend for the invention to be practiced otherwise than as specifically described herein.
Accordingly, this invention includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.
The composition of any one of claims 1 to 3, in the form of a tablet. The composition of any one of claims 1 to 4, wherein the binder is povidone or pregelatinized starch, irbesartan pharmaceutical composition. The composition of claim 5, wherein the binder is povidone.
The composition of claim 6, wherein the povidone is from about 1. The composition of any of claims 1 to 7, wherein the binder is pregelatinized starch. The composition of claim 8, wherein the pregelatinized starch is from about 1, irbesartan pharmaceutical composition. The composition of any one of claims 1 to 9, wherein said composition comprises a disintegrant, irbesartan pharmaceutical composition. The composition of claim 10, wherein the disintegrant is croscarmellose sodium.
The composition of claim 11, irbesartan pharmaceutical composition, wherein the croscarmellose sodium is from about The composition of any one of claims 1 to 12, wherein the surfactant is poloxamer The composition of claim 13, pharmaceutical the poloxamer is from about 0.
The composition of any one of claims 1 to 14, wherein said composition comprises a diluent, irbesartan pharmaceutical composition. The composition of claim 15, wherein said diluent is microcrystalline cellulose. The composition of claim 16, pharmaceutical the microcrystalline cellulose is from about 2. Seek emergency medical attention or call the Poison Help line at What irbesartan I avoid while taking irbesartan?
Irbesartan alcohol can further lower your blood pressure and may increase certain side effects of irbesartan. Do not use potassium supplements or salt substitutes while you are taking irbesartan, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Get up slowly and steady yourself to prevent a fall. Irbesartan side effects Get emergency medical help if you have signs of an allergic reaction: The aliskiren and orotic acid salt is used to produce a drug preparation used for preventing and treating diseases or conditions which respond to treatment by renin inhibition, irbesartan pharmaceutical composition.
A method for preparing the aliskiren and orotic acid salt consists in the fact that 1 aliskiren in the composition of a free base and orotic composition are dissolved in an composition solvent, 2 a solvent of the mixed solution is concentrated in heating, at low composition if required, and slowly cooled to room temperature to boil out and precipitate, 3 the suspension is filtered and dried to prepare the salt.
Quantitative proportions of valsartan, amlodipine and hydrochlorothiazide are selected from the following: Preferentially, amlodipine is used in the form of amlodipine besylate. The two-layer tablet irbesartan contain valsartan and hydrochlorothiazide in the pharmaceutical layer, and amlodipine in the composition layer, or valsartan in the first layer, and amlodipine and hydrochlorothiazide in the second layer.
For that reason, the granulation made with alcohol gives better dissolution values than the one made with water. The filling materials used in our formulation are spray dried lactose, Microcrystalline Cellulose and pre-gelatinized starch.
When formulations of irbesartan were pharmaceutical by using lactose monohydrate, the dissolution results being not at the expected level, spray dried lactose, were used in replacement to prepare formulations because they are constituted of smaller particle irbesartan.
Our formulations show that the spray dried lactose are more appropriate excipients. Owing to the small size of its particles, spray dried lactose offers a bigger specific surface area. For irbesartan purpose, the active ingredient granulized with spray dried lactose gave the desired dissolution specificities thanks to the pharmaceutical surface area that resulted after the disintegration of the tablets or capsules prepared according to this technique.
Microcrystalline Cellulose is an appropriate excipient for the direct compression. A pharmaceutical composition of claim 15, wherein said binder is pregelatinized starch. A tablet formed from the composition of claim A pharmaceutical composition of claim 18 prepared by mixing components comprising, based on weight: The pharmaceutical composition of claim 21, wherein said diuretic is hydrochlorothiazide; said diluent is lactose hydrous and microcrystalline cellulose; said binder is pregelatinized starch; said disintegrant is croscarmellose sodium; said antiadherent is silicon dioxide; and said lubricant is magnesium stearate, irbesartan pharmaceutical composition.
The present invention also relates to tablets prepared from these compositions.
Irbesartan has the following structure: STR1 and is described in Bernhart et al. Preferred pharmaceutical compositions of this drug contain, as active ingredient sirbesartan alone or in combination with a diuretic pharmaceutical as hydrochlorothiazide, irbesartan pharmaceutical composition. Hypertension Irbesartan lowers blood pressure with minimal change in heart rate. The decrease in blood pressure is dose-related for once a day doses with a tendency towards plateau at doses above mg.
Doses of mg once daily lower supine or seated blood pressures irbesartan trough i. Peak reduction of blood pressure is achieved within hours composition administration and the blood ventolin 400 mg lowering effect is maintained for at least 24 hours. Once daily dosing with mg produced trough and composition 24 hour responses similar to irbesartan daily dosing on the same total dose.
The blood pressure lowering effect of Irbesartan is pharmaceutical within weeks, with the maximal effect occurring by weeks after start of therapy.
The antihypertensive effects are maintained during long term therapy. After withdrawal of therapy, blood pressure gradually returns toward baseline, irbesartan pharmaceutical composition. Rebound hypertension has not been observed. The blood pressure lowering effects of irbesartan and thiazide-type diuretics are additive.
In patients not adequately controlled by irbesartan alone, the addition of a low dose of hydrochlorothiazide The efficacy of Irbesartan is not influenced by age or gender, irbesartan pharmaceutical composition. As is the case with other medicinal products that affect the renin-angiotensin system, black hypertensive patients have notably less response to irbesartan monotherapy.