Reglan 10 mg ivp - Metoclopramide - Wikipedia
Use in Patients with Renal or Hepatic Impairment: Depending upon clinical efficacy and safety considerations, the dosage may be increased or decreased as appropriate. Metoclopramide undergoes minimal hepatic metabolism, except for simple conjugation.
Its safe use has been described in patients with advanced liver disease whose renal function was normal. Intravenous doses should be administered as a ivp bolus at least over 3 minutes in order to reduce the risk of adverse effects e. Renal and Hepatic Impairment In reglan with renal impairment or with severe hepatic impairment, a dose reduction is recommended see section 4.
Combination to be avoided Alcohol potentiates the sedative effect of metoclopramide. Combination to be taken into account Due to the prokinetic effect of metoclopramide, the absorption of certain drugs may be modified. Anticholinergics and morphine derivatives Anticholinergics and morphine derivatives may both have a mutual antagonism with metoclopramide on the digestive tract motility.
Central nervous system depressants morphine derivatives, anxiolytics, reglan 10 mg ivp, sedative H1 antihistamines, reglan 10 mg ivp, sedative antidepressants, reglan 10 mg ivp, barbiturates, clonidine reglan related Sedative effects of Central Nervous System depressants and metoclopramide are potentiated. Neuroleptics Metoclopramide may have an additive effect with other neuroleptics on the occurrence of extrapyramidal disorders.
However, reglan severe symptoms are present, therapy should begin with metoclopramide injection IM or IV. Doses of 10 mg may be administered slowly by ivp intravenous route over a 1- to 2-minute period, reglan 10 mg ivp. Administration of metoclopramide reglan up to 10 days may be required before symptoms subside, at which time ivp administration of metoclopramide may be instituted.
The buying codeine japan reglan make a thorough assessment of the risks and benefits prior to prescribing further metoclopramide treatment. For the Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy Intravenous infusions should be made slowly over a period of not less than 15 minutes, ivp minutes before beginning cancer chemotherapy and repeated every 2 hours for two doses, then every 3 hours for three doses.
For doses in excess of 10 mg, reglan 10 mg ivp, metoclopramide injection should be diluted in 50 mL of a parenteral solution. The preferred parenteral solution is Sodium Chloride Injection normal salinewhich when combined with metoclopramide injection, can be stored frozen for up to 4 weeks.
All dilutions may be stored unprotected from light under normal light conditions up to 24 hours after ivp. For the Prevention of Postoperative Nausea and Vomiting Metoclopramide injection should be given intramuscularly near the end of surgery.
The usual adult dose is 10 mg; however, doses of 20 mg may be used. To Facilitate Small Bowel Intubation If the tube has not passed the pylorus with conventional maneuvers in 10 minutes, a single dose undiluted may be administered slowly by the intravenous route over a 1- to 2-minute period. The recommended single dose is: Pediatric patients above 14 years of age and adults — 10 mg metoclopramide base.
Pediatric patients years of age — 2. For dosage, see intubation above. Depending upon clinical efficacy and safety considerations, the dosage may be increased or decreased as appropriate.
Metoclopramide undergoes minimal hepatic metabolism, except for simple conjugation. Its safe use has been described in patients with advanced liver disease whose renal function was normal.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Later its use was extended to treat nausea and vomiting, diabetic gastroparesis, refractory gastroesophageal reflux and postoperative ileus.
Currently, metoclopramide reglan used extensively as a prokinetic and to lesser extent as an antiemetic agent. Metoclopramide use can lead to extrapyramidal symptoms movement disorders or parkinsonism that develop acutely within minutes or days to more pervasive disorders that develop after high doses or long-term use. The extrapyramidal symptoms comprise acute akathisia, dystonia, oculogyric crisis, tremor, and parkinsonism, reglan 10 mg ivp, to tardive ivp such as tardive dyskinesias, dystonia, tremor or myoclonus, and rarely catalepsy Costall and Naylor, ; Miller and Jankovic, ; Sethi, Mixed movement disorders may occur and may be accompanied by behavioral changes such as restlessness, anxiety, generic codeine buy frank psychosis, reglan 10 mg ivp.
Miller and Jankovic identified patients with reglan movement disorders DIMD from a database of patients seen over 12 years, of whom 16 The average duration of metoclopramide use prior to DIMD onset was 12 months range 1 day to 4 years.
Tardive dyskinesias TD are persistent and often irreversible involuntary movements that occur following prolonged neuroleptic therapy Sethi, It speeds up stomach emptying and movement of ivp upper intestines.
Ask the doctor or pharmacist for details.
Metoclopramide 10 mg/2 mL Injection, USP 2 mL Single Dose Vial | Metoclopramide
How to use Metoclopramide Hcl See also Warning section. Read the Medication Guide provided by your pharmacist before you start ivp metoclopramide and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Rarely, reglan edema, including glossal or laryngeal edema. Additive sedative effects can occur when metoclopramide is given with alcohol, sedatives, hypnotics, narcotics, or tranquilizers.
The finding that metoclopramide releases catecholamines in patients with essential hypertension suggests that it should be used cautiously, if at all, reglan 10 mg ivp, in patients receiving monoamine oxidase inhibitors. Absorption of drugs from the stomach may be diminished e.
Gastroparesis gastric stasis may be responsible for poor diabetic control in some patients.
What Is Reglan 10 Mg Used For?
Exogenously administered insulin may begin to act before food has left the stomach and lead to hypoglycemia. Because the action of metoclopramide will influence the delivery of food to the intestines and thus the rate of absorption, insulin dosage or timing of dosage may require adjustment. Symptoms have ranged from mild to severe and have included suicidal ideation and suicide. Metoclopramide cheapest place to buy viagra uk be given to patients with a prior history of depression only if ivp expected benefits outweigh the potential risks.
These usually are seen during the first 24 to 48 hours of treatment with metoclopramide, occur more frequently in pediatric patients and adult patients less ivp 30 years of age and are ivp more frequent at higher doses.
These symptoms may include involuntary movements of limbs and facial grimacing, torticollisreglan 10 mg ivp, oculogyric crisis, rhythmic protrusion of tongue, bulbar type of speech, trismus reglan, or dystonic reactions resembling tetanus. Rarely, dystonic reactions may present as stridor and dyspneapossibly due to laryngospasm. If these symptoms should occur, inject 50 mg diphenhydramine hydrochloride intramuscularly, and they usually will subside.
Benztropine mesylate, 1 to 2 mg intramuscularly, may also be used to reverse these reactions. Parkinsonian-like symptoms have occurred, more commonly within the first 6 months reglan beginning treatment with metoclopramide, reglan 10 mg ivp, but occasionally after longer trazodone with children. These symptoms generally subside within 2 to 3 months following discontinuance of metoclopramide.
The risk of developing tardive dyskinesia increases with the duration of treatment and the total cumulative dose. Treatment with metoclopramide for longer than the recommended 12 weeks should be avoided in all but rare cases where therapeutic benefit is thought to outweigh the risk of developing TD.
Although the risk of developing TD in the general population may be increased among the elderly, women, and diabetics, it is not possible to predict which patients will develop metoclopramide-induced TD.
Both the risk of developing TD and the likelihood that TD will become irreversible increase with duration of treatment and total cumulative dose. Metoclopramide should be discontinued reglan patients who develop signs or symptoms of TD.