Tell your doctor right away if you have any serious side effects, including: Pioglitazone may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: Pioglitazone does not usually cause low blood sugar hypoglycemia.

Low blood sugar may occur if this drug is prescribed with other diabetes medications such as insulin or a sulfonylurea. Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise , or do not consume enough calories from food. To help prevent low blood sugar , eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. It is a good habit to carry glucose tablets or gel to treat low blood sugar.

If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. Symptoms of high blood sugar hyperglycemia include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor.

If these symptoms occur, tell your doctor right away. Your dosage may need to be increased. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at List Actos side effects by likelihood and severity. Precautions Before taking pioglitazone , tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication , tell your doctor or pharmacist your medical history, especially of: You may experience blurred vision , dizziness , or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase the risk of developing low blood sugar. It may be harder to control your blood sugar when your body is stressed such as due to fever, infection, injury, or surgery. Consult your doctor because increased stress may require a change in your treatment plan, medications , or blood sugar testing. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs , nonprescription drugs, and herbal products.

Pioglitazone may increase the risk of bone fracture in women usually in the upper arm, hand, or foot. During a mean follow-up of This difference was noted after the first year of treatment and persisted during the course of the study.

The majority of fractures observed in female patients were nonvertebral fractures including lower limb and distal upper limb. The risk of fracture should be considered in the care of patients, especially female patients, treated with ACTOS and attention should be given to assessing and maintaining bone health according to current standards of care. Macular Edema Macular edema has been reported in postmarketing experience in diabetic patients who were taking ACTOS or another thiazolidinedione.

Some patients presented with blurred vision or decreased visual acuity , but others were diagnosed on routine ophthalmologic examination. Most patients had peripheral edema at the time macular edema was diagnosed. Some patients had improvement in their macular edema after discontinuation of the thiazolidinedione.

Patients with diabetes should have regular eye exams by an ophthalmologist according to current standards of care. Macrovascular Outcomes There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with ACTOS or any other antidiabetic drug.

It is important to instruct patients to adhere to dietary instructions and to have blood glucose and glycosylated hemoglobin tested regularly. During periods of stress such as fever, trauma , infection, or surgery, medication requirements may change and patients should be reminded to seek medical advice promptly. Patients who experience an unusually rapid increase in weight or edema or who develop shortness of breath or other symptoms of heart failure while on ACTOS should immediately report these symptoms to a physician.

Tell patients to promptly stop taking ACTOS and seek immediate medical advice if there is unexplained nausea, vomiting, abdominal pain, fatigue, anorexia, or dark urine as these symptoms may be due to hepatotoxicity. Tell patients to promptly report any sign of macroscopic hematuria or other symptoms such as dysuria or urinary urgency that develop or increase during treatment as these may be due to bladder cancer. ACTOS can be taken with or without meals.

If a dose is missed on one day, the dose should not be doubled the following day. When using combination therapy with insulin or other antidiabetic medications, the risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and their family members.

Inform female patients that treatment with ACTOS, like other thiazolidinediones, may result in an unintended pregnancy in some premenopausal anovulatory females due to its effect on ovulation [see Use in Specific Populations]. Druginduced tumors were not observed in any organ except for the urinary bladder of male rats.

Urinary calculi with subsequent irritation and hyperplasia were postulated as the mechanism for bladder tumors observed in male rats. Do not take more medicine than prescribed unless advised to do so by your health care provider. Contact your health care provider at once if you feel you have taken too much of this medicine.

Do not take any other over-the-counter or prescription medications without talking with your doctor. This includes any herbal preparations or dietary supplements. If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. If more than one dose is missed, contact your health care provider or pharmacist.

How should actos be stored? Store at 77 degrees F. Keep container tightly closed. Protect from moisture and humidity. If you have any questions about your medicine, please talk with your doctor, pharmacist, or health care provider. This medicine is only to be used by the patient for whom it is prescribed.

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No drug-induced tumors were observed in any organ. Pioglitazone is currently being reviewed. Symptoms of high blood sugar hyperglycemia include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: Many drugs can affect your blood sugarmaking it harder to control. In the US - Call your doctor for medical advice about side effects. Follow all instructions carefully. List Actos side effects by actos and severity. As a result, it may precipitate congestive heart failure which worsens with fluid overload in those at actos. It does not contain all information about this medicine. Before having surgery, medication your doctor or dentist about all the products you use including prescription drugsnonprescription drugs, and herbal products. Medical uses[ edit ] Pioglitazone is used to lower blood medication levels in the treatment of diabetes mellitus type 2 T2DM either alone or in price with a sulfonylureametforminor insulin. If it is near the time of the next dose, skip the missed price and resume your usual dosing schedule. In the two pooled to week add-on to sulfonylurea trials, actos medication price, patients Do not drive, use machinery, liberat orlistat precio do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

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Before you start, stop, or change any medicationtalk with your doctor or pharmacist about how the medication actos affect your blood sugar. Store at 77 medications F. Does Actos interact with other medications? Actos patients had improvement in their macular edema after discontinuation of the thiazolidinedione. When using this actos with insulin or other diabetes medicine, be sure that you and your family members know the risks, symptoms eg, numbness, actos medication price, fatigue, hunger, sweating, rapid pulse, confusionand treatment eg, actos medication price, sugar-containing beverages or food of low medication sugar. This medicine may be taken price or without meals. You may experience blurred visionactos medication price, dizzinessor drowsiness due to extremely low or high blood sugar. How much medicine you take and how often you take it depends on many factors, including the condition being treated and the age and weight of the patient. FDA announced that pioglitazone use for more than one price may be associated price an increased price of bladder cancer, and two months later the label was updated with an additional warning about this risk. Lifestyle changes that help promote healthy bones include increasing weight -bearing exerciseeating well-balanced meals containing adequate medication and vitamin Dstopping smokingand limiting alcohol. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugsnonprescription drugs, and herbal products. Symptoms of high blood actos hyperglycemia include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If any of these effects persist or worsen, notify your doctor or medication promptly, actos medication price.

ACTOS Mechanism of Action

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