The chemical structure is: Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol and chloroform and has a molecular weight of Each Diltiazem Hydrochloride Extended-release Capsule Once-a-Day Dosage , for oral administration, contains diltiazem hydrochloride in extended release beads at doses of , , , , and mg.
Each capsule also contains the following: The USP drug release test is pending. Diltiazem produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. The magnitude of blood pressure reduction is related to the degree of hypertension: Diltiazem HCl has been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand.
This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal work loads. Diltiazem has been shown to be a potent dilator of coronary arteries, both epicardial and subendocardial. Spontaneous and ergonovine-induced coronary artery spasm are inhibited by diltiazem. In animal models, diltiazem interferes with the slow inward depolarizing current in excitable tissue.
It causes excitation-contraction uncoupling in various myocardial tissues without changes in the configuration of the action potential. Diltiazem produces relaxation of the coronary vascular smooth muscle and dilation of both large and small coronary vascular smooth muscle and dilation of both large and small coronary arteries at drug levels which cause little or no negative inotropic effect.
The resultant increases in coronary blood flow epicardial and subendocardial occur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in systemic blood pressure and decreases in peripheral resistance. Hemodynamic and Electrophysiologic Effects. Like other calcium channel antagonists, diltiazem decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect in isolated preparations.
In the intact animal, prolongation of the AH interval can be seen at higher doses. In man, diltiazem prevents spontaneous and ergonovine-provoked coronary artery spasm. It causes a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals and, in exercise tolerance studies in patients with ischemic heart disease, reduces the heart rate-blood pressure product for any given work load.
Studies to date, primarily in patients with good ventricular function, have not revealed evidence of a negative inotropic effect; cardiac output, ejection fraction, and left ventricular end diastolic pressure have not been affected. Such data have no predictive value with respect to effects in patients with poor ventricular function, and increased heart failure has been reported in patients with preexisting impairment of ventricular function.
There are as yet few data on the interaction of diltiazem and beta-blockers in patients with poor ventricular function. Breaking or opening the pill may cause too much of the drug to be released at one time. If you have trouble swallowing a diltiazem capsule whole, ask your doctor or pharmacist if it is safe for you to open the capsule and sprinkle the medicine into a spoonful of applesauce to make swallowing easier.
Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule. Use diltiazem regularly to get the most benefit. There's no reason to skimp on your needed Diltiazem prescription.
Print yourself an instant PS Card now. Buying a Pet Prescription? Save money on that too. Mechanisms Of Action Hypertension Diltiazem produces its antihypertensive effect primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance.
The magnitude of blood pressure reduction is related to the degree of hypertension: Angina Diltiazem HCl has been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand. This is accomplished via reductions in heart rate and systemic blood pressure at submaximal and maximal work loads. Diltiazem has been shown to be a potent dilator of coronary arteries, both epicardial and subendocardial.
Spontaneous and ergonovine-induced coronary artery spasms are inhibited by diltiazem. In animal models, diltiazem interferes with the slow inward depolarizing current in excitable tissue.
It causes excitation-contraction uncoupling in various myocardial tissues without changes in the configuration of the action potential.
Diltiazem produces relaxation of the coronary vascular smooth muscle and dilation of both large and small coronary vascular smooth muscle and dilation of both large and small coronary arteries at drug levels which cause little or no negative inotropic effect. The resultant increases in coronary blood flow epicardial and subendocardial occur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in systemic blood pressure and decreases in peripheral resistance.
Diltiazem ER Storage Diltiazem ER Warnings Before taking diltiazem, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Diltiazem ER mg, tell your doctor or pharmacist your medical history, especially of: Diltiazem ER mg may make you dizzy.
Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist that you are taking Diltiazem ER mg. Diltiazem ER mg should be used only when clearly needed during pregnancy.
Discuss the risks and benefits with your doctor. Diltiazem ER mg passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
Tags: flexeril 10mg street value aldara cream prices buy hyzaar 100 25mg loratadine price comparison
© Copyright 2017 Diltiazem er 300 price :: Price Comparisons – Select Product.