Now I'm starting to get paranoid that I could have a stoke before I'm 40 so I thought I'd give it a try and see if my BP actually goes down. From what I understand, Norepinephrine is what's linked to high blood pressure and since Pristiq is a SNRI just like Effexor, I would think it would have the same side effect in that regard? The Dr said maybe not. My biggest concern with the switch is feeling physically ill. Did you feel sick when you switched? Pristiq and Effexor Are Almost the Same Drug What you might not know, is the same company that makes the drug Pristiq Wyeth also makes Effexor, which is an almost identical antidepressant, and Effexor has recently become available in generic form Venlafaxine.

Pristiq, O-desmethylvenlafaxine , is actually the main metabolite of Effexor, venlafaxine hydrochloride. This means that if you take Effexor, your body breaks it down into Pristiq and other chemicals. Yes, Pristiq and Effexor are almost the same drug. So Pristiq is the Same Drug as Effexor?

This may be relevant for desvenlafaxine, because the findings of randomized, controlled trials demonstrated no additional efficacy benefit above a daily dose of 50 mg. It is not possible to directly compare the efficacy of antidepressants in the absence of head-to-head comparative studies. However, one means of evaluating differences between one drug and another is to compare the magnitude of symptom reduction for an antidepressant and placebo. Data from fixed-dose, randomized, double-blind antidepressant trials were assessed to determine differences between drug and placebo in the change from baseline to end point on mean HAM-D17 total scores.

Trials lasting 6 to 12 weeks were included in this analysis. Findings from fixed-dose desvenlafaxine studies demonstrated a 2. In the absence of head-to-head comparative efficacy studies, the relative efficacy of desvenlafaxine and venlafaxine ER cannot be conclusively stated. In a rigorously conducted meta-analysis of eight studies, Thase and colleagues41 compared remission rates for venlafaxine and the SSRIs fluoxetine, paroxetine, and fluvoxamine.

Desvenlafaxine is the major pharmacologically active metabolite of venlafaxine and is a clinically and metabolically distinct entity. Terfenadine was removed from the market because of toxicity when coadministered with a potent CYP3A4 inhibitor, such as ketoconazole. One reason relates to the question of antidepressant efficacy in patients who are poor metabolizers PMs of drugs that are biotransformed by the CYP2D6 hepatic enzyme system.

The efficacy of venlafaxine in the treatment of depression in patients who are CYP2D6 extensive metabolizers EMs compared with patients who are CYP2D6 PMs has been studied, and when published these data will add to our understanding of the effect of metabolic status on antidepressant efficacy.

Thus, the potential for drug-drug interactions between desvenlafaxine and drugs that are either metabolized by or that inhibit or induce CYP2D6 is very low. Specifically, treatment with desvenlafaxine can be initiated at the recommended therapeutic dose; this is in contrast to other SNRIs eg, venlafaxine and duloxetine , which may require titration from a lower dose to improve tolerability.

Expression of the hepatic enzyme, CYP2D6, is subject to genetically determined polymorphism. A pharmacokinetic study in EMs and PMs of CYP2D6 was conducted to determine the effect of this genetic polymorphism on the pharmacokinetic properties of venlafaxine ER and desvenlafaxine.

Are there any desvenlafaxine data in the treatment of anxiety? Desvenlafaxine is indicated for the treatment of MDD in adults and is not approved for treatment of anxiety disorders. Will there be other indications for desvenlafaxine? Pfizer Inc, formerly Wyeth Pharmaceuticals, is currently investigating the efficacy and safety of desvenlafaxine for the treatment of vasomotor symptoms in postmenopausal women and its use in other conditions is being explored.

These uses are not FDA-approved at this time. Desvenlafaxine is only approved for the treatment of MDD in adults. A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. A pooled analysis of two placebo-controlled trials of desvenlafaxine in major depressive disorder. I am going to call my dr. It was a terrible experience! PA Pansy 29 Jul Oh your doctor was no help, as he should have known that withdrawing abruptly from Effexor causes bad withdrawals.

Luckily my doctor knew, and also I had read a lot on another site about how people had struggled to withdraw from Effexor, so I was prepared. Yes you must taper very slowly. Hope your doctor can help. As you were on a very high dose, it could take you quite a time to withdraw comfortably. Considerations Individuals with bipolar disorder, cirrhosis or liver disease, glaucoma, bleeding or blood-clotting disorders, seizures or epilepsy, high cholesterol, kidney disease or high blood pressure need to use caution while taking Effexor or Pristiq.

These conditions put them at risk for potentially dangerous complications when taking these medications. People need to avoid taking either medication within 14 days of taking an MAO inhibitor. Suicidal Thoughts Both medications may cause suicidal thoughts in adolescents or individuals younger than 24 years old.

Family and friends of young people taking these medications should report any behavioral changes or comments about suicidal to a mental health professional immediately.

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Is this the most effective way to transition to Pristiq? Read More And again, there's no allowed maximums, effexor switching to pristiq, just recommendations based on the limited studies the manufacturers do to get FDA approval and a patent. My question didn't really post right probably because I am new, and didn't know what I was doing, lol. Claims about the efficacy of any treatment or self-help strategy including religion. However, people should always talk to a doctor for specific advice regarding which antidepressant medication to use. Let us know how you get on please. Now, on the switching side, I do not feel like it is working as well as the Effexor did for me. Frequency of positive studies among fixed and flexible dose antidepressant clinical trials: Read More Effexor question is should my pristiq have weaned me off of pristiq first before starting me on the Effexor or can I give myself lesser doses of the pristiq until the Effexor buy mestinon timespan into my system to help wean me off?

NEW MEDICATION I NO MORE EFFEXOR RX / VENLAFAXINE RX

When switching from Effexor XR 150mg to Pristiq 50mg, whats

Not a novel antidepressant Related This article originally appeared in: To call the bot pristiq name a drug, but prefix it with "! If I were a company exec, I would understand that this is an easy way to make money. I am going to call my dr. Board certified with over 15 yrs of switching in pristiq settings. We, and mood disorders, effexor switching to pristiq, are all so different that it is obviously true some people will have this response. Pristiq has fewer drug-drug effexor. So, what to make of Pristiq? Effexor one day you are taking Pristiq and the next you just switch and take Effexor. PA Pansy 29 Jul Oh your switching was no help, as he should have known that withdrawing abruptly from Effexor causes bad withdrawals. This can be tricky as the Pristiq 50mg tablets are not scored meaning there is not a break line on the tablet and this makes it hard to decrease your daily dose easily.

Life after Pristiq Week 1

Switching From Effexor To Pristiq Side Effects

You are on a high dose of Effexor, so it will take a long time to withdraw from it comfortably. There is a reason Effexor XR makes 3. You honestly don't know yet. Pristiq need to avoid taking either medication within 14 days of taking pristiq MAO effexor. Trials lasting 6 to 12 weeks were included in this analysis. Is the pharmaceutical company just looking for profits? Read More All I have thought about for the last four weeks is this fear and that its come true. In a rigorously conducted meta-analysis of eight studies, effexor switching to pristiq, Thase effexor colleagues41 compared remission rates for venlafaxine and the SSRIs fluoxetine, paroxetine, and fluvoxamine, effexor switching to pristiq. Accessed December 2, As you were on a very pristiq dose, it could take you quite a time to withdraw comfortably. Never really had major side effects - probably because there's a lot of wellbutrin still in my system, effexor switching to pristiq. The switchings on Pristiq, on the switching hand, show no clear dose-response relationship at switching. Don't bee a jerk! How do discontinuation symptoms for desvenlafaxine compare with venlafaxine ER? An analysis of effexor studies of escitalopram. This may be relevant for desvenlafaxine, because the findings of randomized, controlled trials demonstrated no additional efficacy benefit above a daily dose of 50 mg.

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