Metabolism After the ester cleavage of the exogenously administered estradiol valerate, the metabolism of the drug follows the biotransformation pathways of endogenous estradiol. Estradiol is mainly metabolized in the liver but also extrahepatically e. These processes involve the formation of estrone, estriol, catecholestrogens and sulfate and glucuronide conjugates of these compounds, which are all distinctly less estrogenic or even nonestrogenic.

A certain proportion of estradiol metabolites are excreted in the bile and undergo a so-called enterohepatic circulation. Ultimately estradiol metabolites are mainly excreted as sulfates and glucuronides with the urine.

Steady state conditions In relation to the single dose, approximately two times higher serum levels of estradiol are observed after multiple administration. Estrone, as a less estrogenic metabolite, reaches about 8-times higher concentrations in serum, estrone sulfate reaches approximately times higher concentrations.

After stopping the treatment with Cyclo-Progynova, pre-treatment levels of estradiol and estrone are reached within days. No distinct difference in the estrogen levels is observed between the treatment phase with estradiol valerate alone or in combination with norgestrel. Norgestrel Absorption After oral administration, norgestrel is absorbed rapidly and completely.

The active component of the racemate norgestrel is levonorgestrel which becomes completely bioavailable from the racemate and accounts for about half of the dose of norgestrel. Levonorgestrel binds to albumin and SHBG. If dietary intake is insufficient to achieve mg per day, supplementation may be useful in women who have no contraindication to calcium supplementation.

Long-term therapy for more than 5 years is generally necessary in order to obtain substantive benefits in reducing the risk of bone fracture. Maximal benefits are obtained if estrogen therapy is initiated as soon after menopause as possible. The optimal duration of therapy has not been definitively determined. When used solely for the prevention of postmenopausal osteoporosis, approved non-estrogen treatments should carefully be considered, and estrogen and combined estrogen-progestin products should only be considered for women with significant risk of osteoporosis that outweighs the risks of the drug.

Estradiol valerate 30 mg IM every 1 to 2 weeks. After a mean follow-up of 5. Among women who reported prior use of hormone therapy, the relative risk of invasive breast cancer was 1. Among women who reported no prior use of hormone therapy, the relative risk of invasive breast cancer was 1.

Metastatic disease was rare with no apparent difference between the two groups. Other prognostic factors such as histologic subtype, grade and hormone receptor status did not differ between the groups.

The use of estrogen plus progestin has been reported to result in an increase in abnormal mammograms requiring further evaluation. All women should receive yearly breast examinations by a healthcare provider and perform monthly breast self-examinations. In addition, mammography examinations should be scheduled based on patient age, risk factors, and prior mammogram results.

It is unknown whether these findings apply to younger postmenopausal women. It is unknown whether these findings apply to estrogen alone therapy. Gallbladder disease A 2- to 4-fold increase in the risk of gallbladder disease requiring surgery in postmenopausal women receiving estrogens has been reported. Hypercalcemia Estrogen administration may lead to severe hypercalcemia in patients with breast cancer and bone metastases.

If hypercalcemia occurs, use of the drug should be stopped and appropriate measures taken to reduce the serum calcium level. Visual abnormalities Retinal vascular thrombosis has been reported in patients receiving estrogens. Discontinue medication pending examination if there is sudden partial or complete loss of vision, or a sudden onset of propto-sis, diplopia , or migraine. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of danazol.

If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form capsules: For treatment of mild endometriosis: Adults—At first, to milligrams mg , divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. Children—Use and dose must be determined by your doctor. For treatment of moderate to severe endometriosis: List Estradiol side effects by likelihood and severity.

Precautions Before taking this medication , tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke , blood clots, high blood pressure , and heart attack , especially in women older than Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time such as a long plane flight.

These conditions increase your risk of getting blood clots, especially if you are taking an estrogen product. You may need to stop this medication for a time or take special precautions. This medication may cause blotchy, dark areas on your face and skin melasma.

Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

If you are nearsighted or wear contact lenses , you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur. Children may be more sensitive to the side effects of this drug. Discuss the possible effects of this medication with the doctor, and monitor your child's growth periodically.

Cyclo-Progynova 2mg

Large and repeated doses of estrogen over an extended period of time have mcg shown to accelerate epiphyseal closure, resulting in short adult stature if treatment is initiated 2mg the completion of physiologic puberty in normally developing children. If necessary, the patient should be advised that hormonal buy clomiphene citrate 50mg. Therefore, the appointment of HRT to women with risk factors for VTE risk-benefit ratio of treatment should be carefully weighed valerate discussed with the patient, estradiol valerate 2mg norgestrel 500 mcg. Estrogen administration should be initiated at the lowest dose approved for the indication and then guided by clinical response rather than by serum hormone levels e. The more pills missed and the closer they are to the end of the 500, the higher the risk of a pregnancy. Oestrogens prevent bone loss following norgestrel or Ovariectomy. HRT also has a beneficial effect on the collagen content in the skin, as well estradiol its density, and may also slow down the formation of wrinkles. No specific antidote, symptomatic treatment. Blood pressure should be monitored at regular intervals with estrogen use. Storage conditions Keep in places, inaccessible to children!

How to do your Estradiol Valerate shot at home

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