Metrondazol is quite a powerful antibiotic medication, hence is especially effective when dealing with diverse bacterial infections and diseases. So, if you have faced a certain bacterial related infection, your chances to overcome it are much higher with Flagyl than any other antibiotic drug. Bacterial infections related to such organs as stomach, vagina, respiratory tract, as well as joints and skin, are effectively treated with Flagyl. Additionally, the medicine is also effective with such infections of higher risk as bacterial vaginosis , amebiasis, dracunculiasis, trichomoniasis , and giardiasis.
If the patient is in the beginning stage of Clostridium difficile colitis, Flagyl can provide the initial necessary treatment. Flagyl paired with some other antibiotic medications becomes an effective treatment of bacterial vaginosis, pelvic inflammatory disease, and endocarditis. Dosage Information in more detail What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose.
Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at Overdose symptoms may include nausea, vomiting, dizziness, loss of balance or coordination, numbness and tingling, or seizures convulsions. What should I avoid while taking metronidazole? Do not drink alcohol or consume food or medicines that contain propylene glycol while you are taking metronidazole.
Contact veterinarian immediately if any signs of allergic reactions occur. Do not use in animals allergic to metronidazole or drugs similar to it. Do not give to pregnant or nursing animals. Do not use in animals that may be used for human food. Use extreme caution when using in animals with liver disease or animals who are debilitated. Inform your veterinarian if your pet is using any other supplements, oral anticoagulants, cimetidine, phenobarbital, phenytoin, sedatives or tranquilizers.
In the treatment of most serious anaerobic infections, the intravenous form of metronidazole is usually administered initially. This may be followed by oral therapy with metronidazole tablets at the discretion of the physician.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of metronidazole tablets and other antibacterial drugs, metronidazole tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
In patients with trichomoniasis, metronidazole tablets are contraindicated during the first trimester of pregnancy. WARNINGS Convulsive Seizures and Peripheral Neuropathy Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, have been reported in patients treated with metronidazole.
The appearance of abnormal neurologic signs demands the prompt discontinuation of metronidazole therapy. Metronidazole should be administered with caution to patients with central nervous system diseases. Accordingly, for such patients, doses below those usually recommended should be administered cautiously. Known or previously unrecognized candidiasis may present more prominent symptoms during therapy with metronidazole and requires treatment with a candicidal agent. Prescribing metronidazole tablets in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of development of drug-resistant bacteria.
Information for Patients Alcoholic beverages should be avoided while taking metronidazole tablets and for at least one day afterward. Patients should be counseled that antibacterial drugs including metronidazole tablets should only be used to treat bacterial infections. They do not treat viral infections e. When metronidazole tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by metronidazole tablets or other antibacterial drugs in the future. Laboratory Tests Metronidazole is a nitroimidazole and should be used with caution in patients with evidence of or history of blood dyscrasia. A mild leukopenia has been observed during its administration; however, no persistent hematologic abnormalities attributable to metronidazole have been observed in clinical studies.
Total and differential leukocyte counts are recommended before and after therapy for trichomoniasis and amebiasis, especially if a second course of therapy is necessary, and before and after therapy for anaerobic infections. Drug Interactions Metronidazole has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time.
This possible drug interaction should be considered when metronidazole is prescribed for patients on this type of anticoagulant therapy. The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbital, may accelerate the elimination of metronidazole, resulting in reduced plasma levels; impaired clearance of phenytoin has also been reported.
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