Ranitidine works by reducing the amount of acid your stomach produces. Please read them carefully. Ranitidine was the result of a rational drug-design process utilising the, by then, fairly refined model of the histamine H2-receptor and quantitative structure-activity relationships.
Glaxo refined the model further by replacing the imidazole-ring of cimetidine with a furan-ring with a nitrogen-containing substituent, and in doing so developed ranitidine. Ranitidine was found to have a far-improved tolerability profile i. It has since largely been superseded by the even more effective proton pump inhibitors, with omeprazole becoming the biggest-selling drug for many years.
Why is this medication prescribed? Other uses for this medicine Ranitidine is also used sometimes to treat upper gastrointestinal bleeding and to prevent stress ulcers, stomach damage from use of nonsteroidal anti-inflammatory medications NSAIDs , and aspiration of stomach acid during anesthesia.
However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition. Dosage and using this medicine Ranitidine comes as a tablet, an effervescent tablet, effervescent granules, and a syrup to be taken by mouth. For duodenal ulcers associated with Helicobacter pylori infection, ranitidine mg at bedtime or mg twice daily may be given with oral amoxicillin mg three times daily and metronidazole mg three times daily for two weeks.
Therapy with ranitidine should continue for a further two weeks. This dose regimen significantly reduces the frequency of duodenal ulcer recurrence. Maintenance treatment at a reduced dosage of mg at bedtime is recommended for patients who have responded to short term therapy, particularly those with a history of recurrent ulcer.
Symptom relief in gastro-oesophageal reflux disease. In patients with gastro-oesophageal reflux disease, a dose regimen of mg twice daily for 2 weeks is recommended and this can be repeated in patients in whom the initial symptomatic response is inadequate Oesophageal reflux disease: In the management of oesophageal reflux disease, the recommended course of treatment is either mg twice daily or mg at bedtime for up to 8 weeks or 12 weeks if necessary. In patients with moderate to severe oesophagitis, the dosage of ranitidine may be increased to mg 4 times daily for up to 12 weeks.
For long term treatment, recommended adult dose is mg twice daily. Long term treatment is not indicated in management of patients with unhealed oesophagitis with or without Barrett's epithelium.
The starting dose for Zollinger-Ellison syndrome is mg three times daily, and this may be increased as necessary. To prevent symptoms brought on by consuming food or beverages, take the dose 30 to 60 minutes before eating food or drinking beverages that are expected to cause symptoms.
Do not take it in this manner for more than 2 weeks without seeking medical advice. The injectable form of raniditine may be used in hospitals under specific circumstances when the patient is not able to swallow tablets.
If you are using the oral liquid form of ranitidine, use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Anyone not responding or relapsing shortly afterwards should be investigated. Prophylaxis of haemorrhage from stress ulceration in seriously ill patients or prophylaxis of recurrent haemorrhage in patients bleeding from peptic ulceration: Prophylaxis of acid aspiration Mendelson's syndrome: Alternatively, the injection is also available.
In obstetric patients in labour mg every 6 hours, but if general anaesthesia is required it is recommended that a non-particulate antacid e. The usual precautions to avoid acid aspiration should also be taken. Children 12 years and over For children 12 years and over the adult dosage is given.
Patients over 50 years of age See Section 5. For those patients with incomplete healing, another 4 weeks of therapy is indicated, as healing usually occurs after eight weeks of treatment.
Neonates Safety and efficacy in new-born patients has not been established. In patients with severe renal impairment, plasma levels of the drug are increased. The dose in such patients is mg at night for weeks.
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