Rosuvastatin 20mg versus atorvastatin 80mg

Atorvastatin has extensive metabolism to ortho- and parahydroxylated various beta-oxidation metabolites. On the other hand, rosuvastatin is not extensively metabolized. Studies have showed that rosuvastatin is more effective in reducing LDL cholesterol than atorvastatin. This study showed that patients who were on a therapy with one of these drugs had important reductions in their fatty plaque lining of the arteries, with just a few serious side effects.

Rates of heart attacks, strokes and angioplasty procedures were fewer compared to patients on less aggressive statin regimens. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels.

Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease. Cardiovascular events and their reduction with pravastatin in diabetic and glucose-intolerant myocardial infarction survivors with average cholesterol levels: Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose: Cardiovascular risk factors in patients with type 2 diabetes.

Do we follow the guidelines?. Diabetes Res Clin Pract. Unintended effects of statins in men and women in England and Wales: Drug-induced acute liver failure: Randomized head-to-head comparison of pitavastatin, atorvastatin, and rosuvastatin for safety and efficacy quantity and quality of LDL. Circ J ; Drug safety evaluation of rosuvastatin. Expert Opin Drug Saf ; Cardiac rehabilitation participant with sickle cell trait and statin-related hepatotoxicity: J Cardiopulm Rehabil Prev ; Hepatotoxicity associated with statins: J Hepatol ; Cardiovasc Ther ; Incidence, presentation and outcomes in patients with drug-induced liver injury in the general population of Iceland.

Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports. Ann Hepatol ; Spectrum of statin hepatotoxicity: Int J Cardiol ; Statins and Liver Injury. Gastroenterol Hepatol N Y ; 9: Lipid-lowering agents and hepatotoxicity.

Incidence, presentation and outcomes in patients with drug-induced liver injury in the general population of Iceland. Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports. Ann Hepatol ; Spectrum of statin hepatotoxicity: Experience of the drug-induced liver injury network.

J Clin Lipidol ; 8 3 Suppl: A prospective stratified case-cohort study on statins and multiple adverse events in Japan. PLoS One ; 9: Unintended effects of statins from observational studies in the general population: BMC Med ; Treat Guidel Med Lett ; 12 Acute hepatic injury with atorvastatin: Indian J Pharmacol ; Enferm Infecc Microbiol Clin ; Acta Med Croatica ; Kalantari S, Naghipour M.

Statin therapy and hepatotoxicity: Adv Biomed Res ; 3: Hepatotoxicity associated with statin use: Rev Esp Enferm Dig ; Statins and the risk of liver injury: Pharmacoepidemiol Drug Saf ; Features and outcomes of patients with drug-induced liver injury: Acute liver failure following atorvastatin dose escalation: Severe hepatic injury associated with different statins in patients with chronic liver disease: J Gastroenterol Hepatol ; Statin-related aminotransferase elevation according to baseline aminotransferases level in real practice in Korea.

J Clin Pharm Ther ; High dose atorvastatin associated with increased risk of significant hepatotoxicity in comparison to simvastatin in UK GPRD cohort.

PLoS One ; Doctors should stop administering atorvastatin or simvastatin if liver tests for certain chemical markers remain three times normal concentrations for an extended period. Muscle inflammation caused by Lipitor and Zocor can cause serious damage if muscle protein myoglobin leeches into the bloodstream.

This can cause rhabdomyolysis, a potentially fatal condition that can cause kidney failure because those organs cannot filter myoglobin. Anonther concern with both atorvastatin and simvastatin is they can raise blood sugar and HbA1c levels, mimicking conditions seen in diabetes.

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