Before using this medicine, consult your doctor or pharmacist if you have: The rapidly dissolving tablets may contain aspartame or phenylalanine. If you have phenylketonuria PKU or any other condition that requires you to restrict your intake of aspartame or phenylalanine, consult your doctor or pharmacist regarding the safe use of this medicine.
Antibiotics may rarely cause a severe intestinal condition Clostridium difficile -associated diarrhea due to a type of resistant bacteria.
This condition may occur weeks after antibiotic treatment has stopped. This medication may make this condition worse. Do not use this anti-diarrhea product, especially after recent antibiotic use, if you have the above symptoms without talking with your doctor first.
Nursing Mothers Small amounts of loperamide may appear in human breast milk. Children may be more sensitive to CNS effects than adults. Clinical trials have demonstrated that a slurry of activated charcoal administered promptly after ingestion of loperamide hydrochloride can reduce the amount of drug which is absorbed into the systemic circulation by as much as ninefold.
If vomiting occurs spontaneously upon ingestion, a slurry of gms of activated charcoal should be administered orally as soon as fluids can be retained. If vomiting has not occurred, gastric lavage should be performed followed by administration of gms of the activated charcoal slurry through the gastric tube. In the event of overdosage, patients should be monitored for signs of CNS depression for at least 24 hours.
If symptoms of overdose occur, naloxone can be given as an antidote. If responsive to naloxone, vital signs must be monitored carefully for recurrence of symptoms of drug overdose for at least 24 hours after the last dose of naloxone.
In view of the prolonged action of loperamide and the short duration one to three hours of naloxone, the patient must be monitored closely and treated repeatedly with naloxone as indicated. In clinical trials an adult who took three 20mg doses within a 24 hour period was nauseated after the second dose and vomited after the third dose.
In studies designed to examine the potential for side effects, intentional ingestion of up to 60 mg of loperamide hydrochloride in a single dose to healthy subjects resulted in no significant adverse effects. This moves food through your system too fast.
This causes watery bowel movements that are larger and more frequent than normal. It also increases the amount of fluids and electrolytes that your body loses. Electrolytes are salts the body needs to function well. Having very low levels of fluids and electrolytes can be dangerous.
This condition is called dehydration. The active ingredient in Imodium is the drug loperamide. If there is a suspicion of diarrhea associated with organisms that can penetrate the intestinal walls, such as E.
H7 or salmonella , loperamide is contraindicated as a primary treatment. Loperamide should be administered with caution to people with liver failure due to reduced first pass metabolism. If abdominal distension is noted, therapy with loperamide should be discontinued. There have been rare reports of fatal paralytic ileus associated with abdominal distention.
Most of these reports occurred in the setting of acute dysentery , overdose, and with very young children less than two years of age.
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