The dosage is based on your medical condition and response to treatment. Your doctor may direct you to start this medication at a low dose and gradually increase your dose to reduce the risk of side effects. Follow your doctor's instructions carefully. Use this medication regularly to get the most benefit from it.

To help you remember, use it at the same time each day. If you stop taking this medication for several days, you may need to slowly increase your dose back to your previous dosage. Talk with your doctor about how to restart this medication. Do not stop taking this medication without consulting your doctor. If you suddenly stop taking this drug, withdrawal symptoms such as fever, muscle stiffness, and confusion may occur.

To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Tell your doctor if your condition does not improve or if it worsens.

What conditions does Requip XL treat? If these effects persist or worsen, tell your doctor promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

Many people using this medication do not have serious side effects. You may develop a sudden drop in blood pressure , which can cause dizziness, nausea , and fainting.

This is more likely when you are first starting the medication, when your dose is increased, or when you get up suddenly. To lower your risk, get up slowly from a sitting or lying position. This medication may also raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high. Tell your doctor right away if you have any serious side effects, including: Some people taking ropinirole have fallen asleep suddenly during their usual daily activities such as talking on the phone, driving.

In some cases, sleep occurred without any feelings of drowsiness beforehand. This sleep effect may occur anytime during treatment with ropinirole even if you have used this medication for a long time.

If you experience increased sleepiness or fall asleep during the day, do not drive or take part in other possibly dangerous activities until you have discussed this effect with your doctor. Your risk of this sleep effect is increased by using alcohol or other medications that can make you drowsy.

See also Precautions section. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: Posologie si mod de administrare: Se recomanda dozarea individuala in concordanta cu eficacitatea si toleranta.

Ropinirole trebuie administrat de trei ori pe zi, preferabil odata cu mesele, pentru a ameliora toleranta digestiva. Doza initiala trebuie sa fie de 0,25 mg de trei ori pe zi.

Mai jos este prezentat un exemplu de schema de dozare pentru primele patru saptamani de tratament: Saptamana Doza unitara mg 0,,50,,0 Doza zilnica totala0,,52,,0 Schema terapeutica: Daca nu se obtine o ameliorare clinica convenabila sau nu se mentine sub control simptomatologia, doza de Ropinirole poate fi crescuta pana se obtine un raspuns terapeutic acceptabil.

Nu au fost studiate clinic doze zilnice mai mari de 24 mg, de aceea aceasta doza nu trebuie depasita. Daca se trece de la un tratament cu un alt agonist de dopamina la Ropinirole, trebuie urmate indicatiile producatorului de intrerupere a administrarii agonistului respectiv inainte de a initia terapia cu Ropinirole.

Ca si in cazul altor agonisti de dopamina, intreruperea tratamentului cu Ropinirole trebuie sa se faca treptat, prin reducerea numarului de doze zilnice, pe o perioada de o saptamana. De aceea, nu se recomanda administrarea de ropinirole la acesti pacienti. Clearanceul de ropinirole scade la pacientii in varsta de peste 65 de ani, dar dozarea de ropinirole la persoanele varstnice poate fi cea normala.

De aceea, administrarea de ropinirole la acestia nu a fost studiata si preparatul nu trebuie administrat copiilor. In lumina rezultatelor studiilor intreprinse la animale si a inexistentei studiilor in cazul sarcinii umane, Ropinirole este contraindicat in cursul sarcinii, alaptarii si in cazul femeilor ce se presupune a fi insarcinate, cu exceptia situatiei in care se folosesc mijloace contraceptive adecvate.

Precautii speciale de folosire: Data fiind actiunea farmacologica a produsului, pacientii cu boli cardio-vasculare severe trebuie tratati cu atentie. Administrarea concomitent cu Ropinirole a agentilor antihipertensivi si antiaritmici nu a fost studiata. Ca si in cazul altor medicamente dopaminergice, administrarea acestor compusi concomitent cu ropinirole se va face cu prudenta, deoarece exista posibilitatea aparitiei de hipotensiune, bradicardie sau alte aritmii. Pacientii cu tulburari psihotice majore sunt tratati cu agonisti de dopamina doar daca posibilele avantaje depasesc riscurile.

Interactiuni cu alte medicamente si alte forme de interactiune: Neurolepticele si agonisti de dopamina cu actiune centrala, cum este sulpiridul sau metoclopramidul, pot diminua eficacitatea produsului si, de aceea, trebuie evitata administrarea concomitenta a acestora cu Ropinirole. Nu au fost observate interactiuni farmacocinetice intre Ropinirole si L-dopa sau domperidon, care sa necesite ajustarea dozajului a vreunuia dintre aceste preparate.

Nu au fost observate interactiuni intre Ropinirole si alte medicamente folosite de obicei in boala Parkinson, dar in general trebuie luate precautii atunci cand se introduce un nou medicament in cadrul unei terapii.

Ropinirole nu se administreaza impreuna cu alti agonisti de dopamina. The mechanism of orthostatic hypotension induced by ropinirole is presumed to be due to a D2-mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

Nausea is a common concomitant symptom of orthostatic signs and symptoms. At oral doses as low as 0. Ropinirole had no dose-related effect on ECG wave form and rhythm in young, healthy, male volunteers in the range of 0. The effect of ropinirole on QTc intervals at higher exposures achieved either due to drug interactions, hepatic impairment, or at higher doses has not been systematically evaluated. Accumulation upon multiple dosing is predictive from single dosing.

Absorption Ropinirole is rapidly absorbed after oral administration, reaching peak concentration in approximately 1 to 2 hours. Food does not affect the extent of absorption of ropinirole, although its Tmax is increased by 2.

Distribution Ropinirole is widely distributed throughout the body, with an apparent volume of distribution of 7. Metabolism Ropinirole is extensively metabolized by the liver.

The major metabolic pathways are N-despropylation and hydroxylation to form the inactive N-despropyl metabolite and hydroxy metabolites.

The N-despropyl metabolite is converted to carbamyl glucuronide, carboxylic acid, and N-despropyl hydroxy metabolites. The hydroxy metabolite of ropinirole is rapidly glucuronidated. In vitro studies indicate that the major cytochrome P enzyme involved in the metabolism of ropinirole is CYP1A2, an enzyme known to be induced by smoking and omeprazole and inhibited by, for example, fluvoxamine, mexiletine, and the older fluoroquinolones such as ciprofloxacin and norfloxacin.

Population pharmacokinetic analysis revealed that estrogens mainly ethinylestradiol: Population analysis showed that commonly administered drugs, e. An in vitro study indicates that ropinirole is not a substrate for P-glycoprotein. Ropinirole and its circulating metabolites do not inhibit or induce P enzymes; therefore, ropinirole is unlikely to affect the pharmacokinetics of other drugs by a P mechanism. Specific Populations Because therapy with Requip is initiated at a low dose and gradually titrated upward according to clinical tolerability to obtain the optimum therapeutic effect, adjustment of the initial dose based on gender, weight, or age is not necessary.

Female and male patients showed similar clearance. The influence of race on the pharmacokinetics of ropinirole has not been evaluated.

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Do not stop using Requip or change your dose without first talking to your doctor. Tell your doctor or pharmacist 2mg you are taking other products that can cause drowsiness, including alcohol, marijuanaantihistamines such as modutabdiphenhydraminedrugs for sleep or anxiety such as alprazolamrequipzolpidemmuscle relaxants, requip modutab 2mg, and narcotic pain relievers such as codeine. Store at room temperature away from moisture, heat, and light. Ropinirole 2mg associated with teratogenicity and embryolethality in pregnant rats were associated 25mg viagra experiences maternal toxicity. Ropinirole 2mg its circulating metabolites do not inhibit or induce P enzymes; therefore, ropinirole is unlikely to affect modutab pharmacokinetics of other drugs by a Requip mechanism. During pregnancy modutab, this medication should be used only when clearly needed. Low levels of dopamine in the brain are associated with Modutab disease. In some cases, sleep occurred without any feelings of drowsiness beforehand. Doing requip can release all of the drug at once, requip modutab 2mg, increasing the risk of side effects. Intr-un studiu efectuat cu requip parkinsonieni tratati simultan cu digoxina, nu au fost observate interactiuni care sa necesite ajustarea dozajului, requip modutab 2mg. 2mg, people with Parkinson's disease may have a higher risk than most people for developing melanoma. Posologie si mod de administrare:

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Notes Do not share this medication with others, requip modutab 2mg. Do 2mg start, stop, or change the dosage of modutab medicines without your doctor's approval. In cadrul studiilor clinice nu a fost inregistrata supradozarea intentionala cu Ropinirole. Pacientii trebuie avertizati asupra acestui fapt, deoarece Ropinirole poate induce somnolenta sau ameteli. Posologie 2mg mod de administrare: Ropinirole and its circulating metabolites do not inhibit or requip P enzymes; therefore, ropinirole is unlikely to affect the pharmacokinetics of modutab drugs by a P mechanism, requip modutab 2mg. In these trials, the incidence of overall adverse reactions increased with increasing age for both patients receiving extended-release ropinirole and placebo. If these effects persist or worsen, tell your doctor promptly. Some people who use Requip requip experience sudden onset of severe drowsiness or may even fall asleep during normal daily activities eg, eating, talking, driving.

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